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Synonyms
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N-methylamino acid oxidase
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oxidase, N-methylamino acid
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an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2
an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2
reaction mechanism
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an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2
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N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating)
A flavoprotein.
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alpha-N-methyl-L-histidine + O2 + H2O
L-histidine + formaldehyde + H2O2
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Substrates: -
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alpha-N-methyl-L-tryptophan + O2 + H2O
L-tryptophan + formaldehyde + H2O2
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Substrates: alpha-N-methyl-L-tryptophan is identical with L-abrine
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N-methyl-L-amino acid + O2 + H2O
L-amino acid + formaldehyde + H2O2
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Substrates: enzyme requires the presence of a free alpha-carboxyl group in the substrate molecule, substrates with aromatic or heterocyclic substituents are more readily oxidized, followed by aliphatic N-methylamino acids with long side chain, more slowly activity towards N-methyl derivatives of beta-hydroxy-amino acids and of basic and acidic amino acids with exception of histidin, very slow demethylation of phenylsarcosine
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N-methyl-L-norleucine + O2 + H2O
L-norleucine + formaldehyde + H2O2
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N-methyl-L-phenylalanine + O2 + H2O
L-phenylalanine + formaldehyde + H2O2
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N-methyl-L-tyrosine + O2 + H2O
L-tyrosine + formaldehyde + H2O2
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Substrates: N-methyl-DL-tyrosine is identical with surinamine
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N-methyldihydroxyphenyl-DL-alanine + O2 + H2O
formaldehyde + dihydroxyphenyl-DL-alanine + H2O2
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N-methylvanillyl-L-alanine + O2 + H2O
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additional information
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Substrates: more substrates, not with: N-dimethyl-L-amino acid, N-methyl-D-amino acid, L-amino acid, D-amino acid
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FAD
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as prosthetic group
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additional information
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not inhibited by 0.01 M benzoate, 0.01 M quinine HCl, 0.01 M atabrine, 0.01 M KCN
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0.262
alpha-N-methyl-L-tryptophan
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Highest Expressing Human Cell Lines
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Moritani, M.; Tung, T.C.; Fujii, S.; Mito, H.; Izumiya, N.; Kenmochi, K.; Hirohata, R.
Specificity of rabbit kidney demethylase
J. Biol. Chem.
209
485-492
1954
Oryctolagus cuniculus
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