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Information on EC 1.5.1.6 - formyltetrahydrofolate dehydrogenase and Organism(s) Danio rerio and UniProt Accession E3NZ06

for references in articles please use BRENDA:EC1.5.1.6
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This record set is specific for:
Danio rerio
UNIPROT: E3NZ06 not found.
Word Map
The taxonomic range for the selected organisms is: Danio rerio
The enzyme appears in selected viruses and cellular organisms
Synonyms
10-FDH, 10-formyl tetrahydrofolate:NADP oxidoreductase, 10-formyl-H2PtGlu:NADP oxidoreductase, 10-formyl-H4folate dehydrogenase, 10-formyltetrahydrofolate dehydrogenase, 10-fTHF dehydrogenase, 10-FTHFDH, ALDH1L1, ALDH1L2, dehydrogenase, formyltetrahydrofolate, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10-FDH
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10-formyl tetrahydrofolate:NADP oxidoreductase
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10-formyl-H2PtGlu:NADP oxidoreductase
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10-formyl-H4folate dehydrogenase
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10-formyltetrahydrofolate dehydrogenase
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10-FTHFDH
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dehydrogenase, formyltetrahydrofolate
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FBP-CI
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FBP-CI proteins
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FDH
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folate-binding proteins, cytosol I
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N10-formyltetrahydrofolate dehydrogenase
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proteins, folate-binding, cytosol I
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
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redox reaction
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reduction
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:NADP+ oxidoreductase
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CAS REGISTRY NUMBER
COMMENTARY hide
37256-25-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + NADP+ + H2O
tetrahydrofolate + CO2 + NADPH + H+
show the reaction diagram
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?
additional information
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0127 - 0.0156
10-formyltetrahydrofolate
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
97
10-formyltetrahydrofolate
30°C, pH not specified in the publication, full-length recombinant enzyme
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
1.04
30°C, pH not specified in the publication, recombinant enzyme expressed in Pichia pastoris
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
E3NZ06_DANRE
903
0
100155
TrEMBL
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
4 * 100000, calculated
400000
gel fitlration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
tetramer
4 * 100000, calculated
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
recombinant protein
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli and Pichia pastoris
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Chang, W.N.; Lin, H.C.; Fu, T.F.
Zebrafish 10-formyltetrahydrofolate dehydrogenase is similar to its mammalian isozymes for its structural and catalytic properties
Protein Expr. Purif.
72
217-222
2010
Danio rerio, Danio rerio (E3NZ06)
Manually annotated by BRENDA team
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