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Information on EC 1.5.1.49 - 1-pyrroline-2-carboxylate reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.49
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IUBMB Comments
The enzyme from the bacterium Colwellia psychrerythraea is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with 1-piperideine-2-carboxylate and 1-pyrroline-2-carboxylate, this enzyme is specific for the latter. While the enzyme is active with both NADH and NADPH, activity is higher with NADPH.
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The expected taxonomic range for this enzyme is: Colwellia psychrerythraea
Synonyms
LhpH, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+
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