Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.5.1.28 - Opine dehydrogenase

for references in articles please use BRENDA:EC1.5.1.28

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

in the forward direction, the enzyme from Arthrobacter sp. acts also on secondary amine dicarboxylates such as N-(1-carboxyethyl)methionine and N-(1-carboxyethyl)phenylalanine. Dehydrogenation forms an imine, which dissociates to the amino acid and pyruvate. In the reverse direction, the enzyme acts also on neutral amino acids as an amino donor. They include L-amino acids such as 2-aminopentanoic acid, 2-aminobutyric acid, 2-aminohexanoic acid, 3-chloroalanine, O-acetylserine, methionine, isoleucine, valine, phenylalanine, leucine and alanine. The amino acceptors include 2-oxoacids such as pyruvate, oxaloacetate, glyoxylate and 2-oxobutyrate.

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota

Synonyms
opine dehydrogenase, n-(1-d-carboxyethyl)-l-norvaline dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(2S)-2-{[1-(R)-carboxyethyl]amino}pentanoate + NAD+ + H2O = L-2-aminopentanoic acid + pyruvate + NADH + H+
show the reaction diagram
-
-
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links