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Information on EC 1.5.1.21 - 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH) and Organism(s) Rattus norvegicus and UniProt Accession Q9QYU4

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EC Tree
IUBMB Comments
The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q9QYU4
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The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
pip2cr, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ketimine reductase
-
mu-crystallin
-
1,2-didehydropipecolate reductase
-
-
-
-
1,2-didehydropipecolic reductase
-
-
-
-
DELTA1-piperideine-2-carboxylate reductase
-
-
-
-
ketimine reductase
-
-
L-pipecolate:NADP+ 2-oxidoreductase
-
-
-
-
P2C reductase
P2C/Pyr2C reductase
-
-
reductase, DELTA 1-piperideine-2-carboxylate
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidation
-
-
-
-
reduction
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-pipecolate/L-proline:NADP+ 2-oxidoreductase
The enzyme is involved in the catabolism of D-lysine and D-proline in bacteria that belong to the Pseudomonas genus. In contrast to EC 1.5.1.1, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H], which shows similar activity with NADPH and NADH, this enzyme is specific for NADPH.
CAS REGISTRY NUMBER
COMMENTARY hide
52037-88-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
1-piperideine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
-
-
-
-
r
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
show the reaction diagram
-
-
-
-
r
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
DELTA1-piperideine 2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
-
-
-
r
1-piperideine-2-carboxylate + NADPH + H+
L-pipecolate + NADP+
show the reaction diagram
-
-
-
-
r
1-pyrroline-2-carboxylate + NADPH + H+
L-proline + NADP+
show the reaction diagram
-
-
-
-
r
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
the enzyme activity is potently inhibited by thyroid hormones
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.2
-
reduction of 1-piperideine-2-carboxylate
5.4
-
reduction of 1-pyrroline-2-carboxylate
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
especially in frontal and temporal cortex, the level of L-pipecolate is highest in the cerebellum
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview
physiological function
CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones
additional information
enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CRYM_RAT
313
0
33554
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hallen, A.; Jamie, J.F.; Cooper, A.J.
Lysine metabolism in mammalian brain an update on the importance of recent discoveries
Amino Acids
45
1249-1272
2013
Bos taurus, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Hallen, A.; Cooper, A.J.
Reciprocal control of thyroid binding and the pipecolate pathway in the brain
Neurochem. Res.
42
217-243
2017
Canis lupus familiaris, Homo sapiens (Q14894), Mus musculus (O54983), Ovis aries (W5PYW4), Rattus norvegicus (Q9QYU4), Sus scrofa (F1RPC8)
Manually annotated by BRENDA team