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Information on EC 1.4.99.6 - D-arginine dehydrogenase

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IUBMB Comments
Contains a non-covalent FAD cofactor. The enzyme, which has been isolated from the bacterium Pseudomonas aeruginosa PAO1, forms with EC 1.4.1.25, L-arginine dehydrogenase, a two-enzyme complex involved in the racemization of D- and L-arginine. The enzyme has a broad substrate range and can act on most D-amino acids with the exception of D-glutamate and D-aspartate. However, activity is maximal with D-arginine and D-lysine. Not active on glycine.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
d-amino acid dehydrogenase, d-alanine dehydrogenase, daadh, nadp+-dependent d-amino acid dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-arginine + acceptor + H2O = 5-guanidino-2-oxopentanoate + NH3 + reduced acceptor
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a flavoprotein, FAD; A flavoprotein, FAD. Acts to some extent on all D-amino acids, except D-aspartate and D-glutamate; overall reaction
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D-arginine + acceptor = iminoarginine + reduced acceptor
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(1a)
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iminoarginine + H2O = 5-guanidino-2-oxopentanoate + NH3
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(1b), spontaneous
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PATHWAY SOURCE
PATHWAYS
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