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Semicarbazide
causes significant decreases in the oxidative deamination activity of four among the five substrates catalyzed by SSAO
(2-phenylprop-2-en-1-yl)hydrazine
-
-
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1-ethyl-2-[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
-
1-[2-(4-fluorophenyl)prop-2-en-1-yl]-2-methylhydrazine
-
-
2-amino-N-[2-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[2-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[3-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[4-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
-
3-(4-methoxyphenyl)-N-methyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
3-[2-(3-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrole
-
-
aminoguanidine
-
strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats. Aminoguanidine may be useful for treating obesity via its SSAO blocking properties
hydroxylamine
-
elicits hypotension in the rat. This effect is due in part to its conversion to nitric oxide and in part to a hydralazine-like action involving SSAO inhibition
N-allyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
N-ethyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
-
-
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
-
-
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
-
-
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
-
Semicarbazide
-
-
Semicarbazide
-
irreversible inhibitor. Pargyline + semicarbazide-induced reduction of fat deposition results from decreased food intake and from impaired MAO (EC 1.4.3.4) and SSAO-dependent lipogenic and antilipolytic actions of endogenous or alimentary amines
additional information
clorgyline and deprenyl do not significantly inhibit the activities
-
additional information
-
no inhibition by pargyline. SSAO activity remains unchanged during starvation
-
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0.000002
(2-phenylprop-2-en-1-yl)hydrazine
Rattus norvegicus
-
-
0.000009
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
Rattus norvegicus
-
-
0.00023
1-ethyl-2-[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
Rattus norvegicus
-
-
0.0000017
1-[2-(4-fluorophenyl)prop-2-en-1-yl]-2-methylhydrazine
Rattus norvegicus
-
-
0.000015
2-amino-N-[2-fluoro-3-(trifluoromethyl)benzyl]acetamide
Rattus norvegicus
-
-
0.00001
2-amino-N-[2-fluoro-5-(trifluoromethyl)benzyl]acetamide
Rattus norvegicus
-
-
0.000033
2-amino-N-[3-fluoro-5-(trifluoromethyl)benzyl]acetamide
Rattus norvegicus
-
-
0.00018
2-amino-N-[4-fluoro-3-(trifluoromethyl)benzyl]acetamide
Rattus norvegicus
-
-
0.042
3-(4-methoxyphenyl)-N-methyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
-
-
0.0005
3-[2-(3-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrole
Rattus norvegicus
-
-
0.225
N-allyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
-
-
0.17
N-ethyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
Rattus norvegicus
-
-
0.000005
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
Rattus norvegicus
-
-
0.000004
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
Rattus norvegicus
-
-
0.000003
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
Rattus norvegicus
-
-
0.000006
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
Rattus norvegicus
-
-
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Ochiai, Y.; Itoh, K.; Sakurai, E.; Adachi, M.; Tanaka, Y.
Substrate selectivity of monoamine oxidase A, monoamine oxidase B, diamine oxidase, and semicarbazide-sensitive amine oxidase in COS-1 expression systems
Biol. Pharm. Bull.
29
2362-2366
2006
Rattus norvegicus (O08590)
brenda
Yraola, F.; Garcia-Vicente, S.; Marti, L.; Albericio, F.; Zorzano, A.; Royo, M.
Understanding the mechanism of action of the novel SSAO substrate (C7NH10)6(V10O28).2H2O, a prodrug of peroxovanadate insulin mimetics
Chem. Biol. Drug Des.
69
423-428
2007
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Dunkel, P.; Gelain, A.; Barlocco, D.; Haider, N.; Gyires, K.; Sperlagh, B.; Magyar, K.; Maccioni, E.; Fadda, A.; Matyus, P.
Semicarbazide-sensitive amine oxidase/vascular adhesion protein 1: recent developments concerning substrates and inhibitors of a promising therapeutic target
Curr. Med. Chem.
15
1827-1839
2008
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Fracassini, L.; Alfarano, C.; Romagnani, B.; Pirisino, R.; Raimondi, L.
Endogenous substrates of the semicarbazide-sensitive amine oxidase increased nitric oxide production in rat white adipocytes
Inflamm. Res.
57
S53-S54
2008
Rattus norvegicus
brenda
Yabanoglu, S.; Ucar, G.; Gokhan, N.; Salgin, U.; Yesilada, A.; Bilgin, A.A.
Interaction of rat lung SSAO with the novel 1-N-substituted thiocarbamoyl-3-substituted phenyl-5-(2-pyrolyl)-2-pyrazoline derivatives
J. Neural Transm.
114
769-773
2007
Rattus norvegicus
brenda
Soltesz, Z.; Tabi, T.; Halasz, A.S.; Palfi, M.; Kocsis, E.; Magyar, K.; Toth, M.; Szoekoe, E.
Studies on the insulinomimetic effects of benzylamine, exogenous substrate of semicarbazide-sensitive amine oxidase enzyme in streptozotocin induced diabetic rats
J. Neural Transm.
114
851-855
2007
Rattus norvegicus
brenda
Vidrio, H.; Medina, M.
Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor
J. Neural Transm.
114
863-865
2007
Rattus norvegicus
brenda
Sibon, I.; Mercier, N.; Darret, D.; Lacolley, P.; Lamaziere, J.M.
Association between semicarbazide-sensitive amine oxidase, a regulator of the glucose transporter, and elastic lamellae thinning during experimental cerebral aneurysm development: laboratory investigation
J. Neurosurg.
108
558-566
2008
Rattus norvegicus
brenda
ORourke, A.M.; Wang, E.Y.; Miller, A.; Podar, E.M.; Scheyhing, K.; Huang, L.; Kessler, C.; Gao, H.; Ton-Nu, H.T.; Macdonald, M.T.; Jones, D.S.; Linnik, M.D.
Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity
J. Pharmacol. Exp. Ther.
324
867-875
2008
Homo sapiens, Mus musculus, Rattus norvegicus
brenda
Carpene, C.; Iffiu-Soltesz, Z.; Bour, S.; Prevot, D.; Valet, P.
Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats
Pharmacol. Res.
56
522-530
2007
Rattus norvegicus
brenda
Prevot, D.; Soltesz, Z.; Abello, V.; Wanecq, E.; Valet, P.; Unzeta, M.; Carpene, C.
Prolonged treatment with aminoguanidine strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats
Pharmacol. Res.
56
70-79
2007
Rattus norvegicus
brenda
Carpene, C.; Abello, V.; Iffiu-Soltesz, Z.; Mercier, N.; Feve, B.; Valet, P.
Limitation of adipose tissue enlargement in rats chronically treated with semicarbazide-sensitive amine oxidase and monoamine oxidase inhibitors
Pharmacol. Res.
57
426-434
2008
Rattus norvegicus
brenda
Iffiu-Soltesz, Z.; Prevot, D.; Carpene, C.
Influence of prolonged fasting on monoamine oxidase and semicarbazide-sensitive amine oxidase activities in rat white adipose tissue
J. Physiol. Biochem.
65
11-23
2009
Rattus norvegicus
brenda
Stevanato, R.; Cardillo, S.; Braga, M.; De Iuliis, A.; Battaglia, V.; Toninello, A.; Agostinelli, E.; Vianello, F.
Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix
Amino Acids
40
713-720
2011
Rattus norvegicus
brenda
Martelius, T.; Salmi, M.; Krogerus, L.; Loginov, R.; Schoultz, M.; Karikoski, M.; Miiluniemi, M.; Soots, A.; Hoeckerstedt, K.; Jalkanen, S.; Lautenschlager, I.
Inhibition of semicarbazide-sensitive amine oxidases decreases lymphocyte infiltration in the early phases of rat liver allograft rejection
Int. J. Immunopathol. Pharmacol.
21
911-920
2009
Rattus norvegicus
brenda