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1,4-diamino-2-butyne + H2O + O2
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
1,4-diaminobutane + H2O + O2
?
-
enzyme II shows 23% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
1,5-diaminopentane + H2O + O2
?
-
enzyme II shows 5% activity and enzyme III 31% activity compared to 4-aminobutanamide
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
1,8-diaminooctane + H2O + O2
?
-
-
-
-
?
1,8-diaminopropane + H2O + O2
3-aminopropanal + NH3 + H2O2
-
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
1-aminobutane + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
1-aminoheptane + H2O + O2
heptanal + NH3 + H2O2
-
-
-
-
?
1-aminohexane + H2O + O2
hexanal + NH3 + H2O2
-
-
-
-
?
1-aminononane + H2O + O2
nonanal + NH3 + H2O2
-
the aliphatic chain of 1-aminononane induces a shift in the pKa-value of the product Schiff base, the hydrolysis of which appears to be a rate-determining step of the reaction
-
-
?
1-aminooctane + H2O + O2
octanal + NH3 + H2O2
-
-
-
-
?
1-aminopentane + H2O + O2
pentanal + NH3 + H2O2
-
-
-
-
?
1-methyl-3-phenylpropylamine + H2O + O2
4-phenylbutan-2-one + NH3 + H2O2
-
-
-
-
?
1-methylhistamine + O2 + H2O
?
-
-
-
?
2-aminoethylpyridine + H2O + O2
pyridine-2-carbaldehyde + NH3 + H2O2
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
2-phenylethylamine + H2O + O2
4-phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
?
-
-
-
?
2-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
3-aminomethylpyridine + H2O + O2
pyridine-3-carbaldehyde + NH3 + H2O2
-
-
-
?
3-aminopentanamide + H2O + O2
3-oxopentanamide + NH3 + H2O2
-
enzyme II shows 214% activity and enzyme III 11% activity compared to 4-aminobutanamide
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
4-amino-1-butanol + H2O + O2
4-hydroxybutanal + NH3 + H2O2
-
enzyme II shows 525% activity and enzyme III 267% activity compared to 4-aminobutanamide
-
-
?
4-aminobutanamide + H2O + O2
4-oxobutanamide + NH3 + H2O2
-
100% activity
-
-
?
4-aminobutyric acid + H2O + O2
4-oxobutanoate + NH3 + H2O2
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
4-aminomethylpyridine + H2O + O2
pyridine-4-carbaldehyde + NH3 + H2O2
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
4-fluorobenzylamine + H2O + O2
4-fluorobenzaldehyde + NH3 + H2O2
-
-
-
-
?
4-N,N-dimethylaminomethyl benzylamine + H2O + O2
?
-
-
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
4-tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
5-amino-1-pentanol + H2O + O2
5-hydroxypentanal + NH3 + H2O2
-
enzyme II shows 86% activity and enzyme III 388% activity compared to 4-aminobutanamide
-
-
?
5-aminopentanoic acid + H2O + O2
5-oxopentanoate + NH3 + H2O2
-
enzyme II shows 3% activity and enzyme III 7% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
agmatine + H2O + O2
?
-
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
alpha-casein + H2O + O2
?
-
the enzyme oxidizes the lysine residues in alpha-casein protein
-
-
?
aminoacetone + H2O + O2
methylglyoxal + NH3 + H2O2
-
-
-
-
?
amphetamine + H2O + O2
1-phenylpropan-2-one + NH3 + H2O2
-
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
benzylamine + O2 + H2O
benzaldehyde + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + H2O + O2
beta-phenylethanal + NH3 + H2O2
-
-
-
?
beta-phenylethylamine + O2 + H2O
beta-phenylethanal + NH3 + H2O2
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
cadaverine + H2O + O2
DELTA1-piperideine + NH3 + H2O2
best substrate
-
-
?
cyclohexanemethylamine + H2O + O2
cyclohexanecarbaldehyde + NH3 + H2O2
-
-
-
-
?
cysteamine + H2O + O2
sulfanylacetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
dopamine + H2O + O2
?
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
ethylamine + H2O + O2
ethanal + NH3 + H2O2
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
isobutylamine + H2O + O2
isobutyraldehyde + NH3 + H2O2
-
-
-
-
?
isopentylamine + H2O + O2
isopentylaldehyde + NH3 + H2O2
-
-
-
-
?
methyl 1-(2-methoxyethyl)-3-(trifluoroacetyl)-1H-indole-4-carboxylate + H2O + O2
?
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
methylamine + H2O + O2
methanal + NH3 + H2O2
methylbenzylamine + H2O + O2
methylbenzaldehyde + NH3 + H2O2
-
-
-
-
?
n-butylamine + H2O + O2
butanal + NH3 + H2O2
-
enzyme II shows 368% activity and enzyme III 454% activity compared to 4-aminobutanamide
-
-
?
n-hexylamine + H2O + O2
hexanal + NH3 + H2O2
-
enzyme II shows 244% activity and enzyme III 589% activity compared to 4-aminobutanamide
-
-
?
n-pentylamine + H2O + O2
pentanal + NH3 + H2O2
-
enzyme II shows 314% activity and enzyme III 596% activity compared to 4-aminobutanamide
-
-
?
n-propylamine + H2O + O2
propanal + NH3 + H2O2
-
enzyme II shows 515% activity and enzyme III 201% activity compared to 4-aminobutanamide
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
Nalpha-benzyloxycarbony-L-lysine + H2O + O2
?
-
enzyme II shows 3% activity and enzyme III 12% activity compared to 4-aminobutanamide
-
-
?
Nalpha-Z-D-lysine + H2O + O2
?
-
enzyme II shows no activity and enzyme III 10% activity compared to 4-aminobutanamide
-
-
?
octopamine + H2O + O2
hydroxy(hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
ornithine + H2O + O2
?
ornithine can be transformed in glutamate-5-semialdehyde spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
?
phenethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
phenylethyl amine + H2O + O2
phenylethanal + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
propylamine + H2O + O2
propanal + NH3 + H2O2
putrescine + H2O + O2
4-aminobutanal + NH3 + H2O2
-
best substrate
-
-
?
putrescine + H2O + O2
4-aminobutyraldehyde + NH3 + H2O2
-
-
-
-
?
pyrrolidine + 2,4,5-trihydroxyphenylalanine quinone + H2O + O2
? + H2O2 + NH3
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
sec-butylamine + H2O + O2
butan-2-one + NH3 + H2O2
-
-
-
-
?
serotonin + O2 + H2O
(5-hydroxy-1H-indol-3yl)acetaldehyde + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2
? + NH3 + H2O2
good substrate. The oxidation of spermidine yields to the liberation of ammonia, hydrogen peroxide and the corresponding aldehyde that spontaneously cyclizes yielding first 1-(3-aminopropyl)pyrroliniun and, thereafter, 1,5-diazobicyclononane
-
-
?
spermine + H2O + O2
? + NH3 + H2O2
good substrate
-
-
?
tropoelastin + H2O + O2
?
-
the enzyme oxidizes the lysine residues in tropoelastin protein
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
tyramine + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
tyramine + O2 + H2O
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
vanillylamine + H2O + O2
vanillic aldehyde + NH3 + H2O2
-
-
-
-
?
additional information
?
-
1,4-diamino-2-butyne + H2O + O2

?
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
-
-
-
?
1,4-diamino-2-butyne + H2O + O2
?
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2

?
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
-
-
-
?
1,4-diamino-2-chloro-2-butene + H2O + O2
?
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2

?
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
-
-
-
?
1,5-diamino-2-pentyne + H2O + O2
?
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2

?
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
-
-
-
?
1,6-diamino-2,4-hexadiyne + H2O + O2
?
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
1-(3-fluoro-4-methylphenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
1-(4-fluorophenyl)methanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
2-bromoethylamine + H2O + O2

bromoacetaldehyde + NH3 + H2O2
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-bromoethylamine + H2O + O2
bromoacetaldehyde + NH3 + H2O2
-
-
-
?
2-phenylethanamine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
2-phenylethanamine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2

2-phenylethanal + NH3 + H2O2
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
2-phenylethanal + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2

phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
enzyme II shows 134% activity and enzyme III 591% activity compared to 4-aminobutanamide
-
-
?
2-phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
best substrate
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2

?
-
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
-
-
-
?
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene + H2O + O2
?
-
-
-
?
3-phenylpropan-1-amine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
3-phenylpropan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
4-(aminomethyl)-N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2

?
45% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (beta-phenylethylamine, 1 mM) for various amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
less than 0.1% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (putrescine, 1 mM) for various amine oxidases
-
-
?
4-aminomethylpyridine dihydrochloride + H2O + O2
?
-
87% substrate activity of 1 mM 4-aminomethylpyridine dihydrochloride as percentage of the activity of the best substrate (benzylamine, 1 mM) for various amine oxidases
-
-
?
4-phenylbutan-1-amine + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
4-phenylbutan-1-amine + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
4-phenylbutylamine + H2O + O2

4-phenylbutanal + NH3 + H2O2
-
enzyme II shows 122% activity and enzyme III 493% activity compared to 4-aminobutanamide
-
-
?
4-phenylbutylamine + H2O + O2
4-phenylbutanal + NH3 + H2O2
-
enzyme II shows 122% activity and enzyme III 493% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2

?
-
enzyme II shows no activity and enzyme III 6% activity compared to 4-aminobutanamide
-
-
?
5-hydroxytryptamine + H2O + O2
?
-
enzyme II shows no activity and enzyme III 6% activity compared to 4-aminobutanamide
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
allyl [3-(aminomethyl)benzyl]carbamate + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
amylamine + H2O + O2

pentanal + NH3 + H2O2
-
-
-
-
?
amylamine + H2O + O2
pentanal + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2

benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
very poor substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 157% activity compared to 4-aminobutanamide
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 157% activity compared to 4-aminobutanamide
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
684285, 685663, 686052, 686264, 686502, 687449, 688255, 688488, 688603, 701561, 712709 -
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
best substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
low activity
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
best oxidized substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
best oxidized substrate
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
-
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
-
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
686052, 686264, 687077, 688484, 688489, 688553, 688603, 689375, 689376, 705350, 712188 -
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
main substrate for isoform AO1
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
main substrate for isoform AO1
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
-
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
benzylamine + H2O + O2
benzaldehyde + NH3 + H2O2
-
-
-
-
?
butylamine + H2O + O2

butanal + NH3 + H2O2
-
-
-
-
?
butylamine + H2O + O2
butanal + NH3 + H2O2
-
-
-
-
?
cadaverine + H2O + O2

?
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
?
cadaverine + H2O + O2
?
-
-
-
-
?
dopamine + H2O + O2

(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
dopamine + H2O + O2
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2

glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethanolamine + H2O + O2
glycolaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2

acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
enzyme II shows 1124% activity and enzyme III 119% activity compared to 4-aminobutanamide
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
isoforms AO1 and AO2 show 100% activity with ethylamine
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
ethylamine + H2O + O2
acetaldehyde + NH3 + H2O2
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2

?
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
-
-
-
-
?
hexakis(benzylammonium) decavanadate (V) dihydrate + H2O + O2
?
-
-
-
-
?
histamine + H2O + O2

(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
(imidazol-4-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2

1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
enzyme II shows 6% activity and enzyme III 322% activity compared to 4-aminobutanamide
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
enzyme II shows 6% activity and enzyme III 322% activity compared to 4-aminobutanamide
-
-
?
histamine + H2O + O2
1H-imidazol-4-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
histamine + H2O + O2

?
-
-
-
?
histamine + H2O + O2
?
-
-
-
?
isoamylamine + H2O + O2

isoamylaldehyde + NH3 + H2O2
-
-
-
-
?
isoamylamine + H2O + O2
isoamylaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2

formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
formaldehyde + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2

methanal + NH3 + H2O2
-
-
-
-
-
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
-
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
?
methylamine + H2O + O2
methanal + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]-4-bromobenzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]acetamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]benzamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2

? + NH3 + H2O2
-
-
-
-
?
N-[3-(aminomethyl)benzyl]propanamide + H2O + O2
? + NH3 + H2O2
-
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2

?
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
-
-
-
?
N6-(4-aminobut-2-ynyl)adenine + H2O + O2
?
-
-
-
?
phenylethylamine + H2O + O2

phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
main substrate for isoform AO2
-
-
?
phenylethylamine + H2O + O2
phenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2

propanal + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
?
propylamine + H2O + O2
propanal + NH3 + H2O2
-
-
-
-
?
putrescine + H2O + O2

?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
best substrate
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
putrescine can be oxidatively deaminated by the enzyme to corresponding aldehyde that spontaneously cyclizes yielding DELTA1-pyrroline
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
-
-
-
?
putrescine + H2O + O2
?
-
-
-
?
putrescine + H2O + O2
?
-
best substrate
-
-
?
RCH2NH2 + H2O + O2

RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
RCH2NH2 + H2O + O2
RCHO + NH3 + H2O2
-
-
-
?
spermidine + H2O + O2

?
-
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
?
spermidine + H2O + O2
?
-
-
-
-
?
spermine + H2O + O2

?
-
-
-
-
?
spermine + H2O + O2
?
-
-
-
?
spermine + H2O + O2
?
-
-
-
-
?
tryptamine + H2O + O2

(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
enzyme II shows 4% activity and enzyme III 175% activity compared to 4-aminobutanamide
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
(1H-indol-3-yl)acetaldehyde + NH3 + H2O2
high activity
-
-
?
tryptamine + H2O + O2

1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tryptamine + H2O + O2
1H-indol-3-ylacetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2

(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
preferred substrate
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
(4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2

4-hydroxyphenylacetaldehyde + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylacetaldehyde + NH3 + H2O2
during this reaction, an irreversible inactivation of the enzyme occurs
-
-
?
tyramine + H2O + O2

4-hydroxyphenylethanal + NH3 + H2O2
-
quantum mechanical hydrogen tunneling can be enhanced by an enzyme protein scaffold including the catalytic base that directly mediates the hydrogen transfer
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
high activity
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
?
tyramine + H2O + O2
4-hydroxyphenylethanal + NH3 + H2O2
-
-
-
-
?
additional information

?
-
-
no activity with dopamine, 2-aminoacetic acid, 3-aminopropanoic aid, L-Arg, L-Orn, L-Lys, L-Phe, and D-Lys
-
-
-
additional information
?
-
-
no activity with dopamine, 2-aminoacetic acid, 3-aminopropanoic aid, L-Arg, L-Orn, L-Lys, L-Phe, and D-Lys
-
-
-
additional information
?
-
-
MAO-N is a flavoenzyme that catalyses the oxidative deamination of primary amines, substrate specificity, overview
-
-
-
additional information
?
-
-
MAO-N is an FAD-dependent enzyme that catalyses the conversion of terminal amines to their corresponding aldehyde
-
-
-
additional information
?
-
-
Semicarbazide-sensitive amine oxidase acts as a vascular-adhesion protein, mediating the adhesion of lymphocytes to vascular endothelial cells under inflammatory conditions
-
-
-
additional information
?
-
the catalytic reaction proceeds via two half-reactions; the aldehyde product is released at the end of the reductive half-reaction before reduction of molecular oxygen in the oxidative half-reaction. Mechanism of molecular oxygen entry into the buried active site of the copper amine oxidase, the N-terminal domain does not affect oxygen entry, overview. The protein-derived cofactor TPQ and the off-metal O2-binding site are located in the vicinity of a conserved active-site Met699
-
-
-
additional information
?
-
-
the enzyme can use human granulocytes as a substrate
-
-
-
additional information
?
-
-
the enzyme oxidizes arginine to ammonia, urea, hydrogen peroxide and glutamate-5-semialdehyde which spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
-
additional information
?
-
the enzyme oxidizes arginine to ammonia, urea, hydrogen peroxide and glutamate-5-semialdehyde which spontaneously cyclizes yielding DELTA1-pyrroline-5-carboxylic acid
-
-
-
additional information
?
-
-
physiologic role for SSAO in elastin maturation
-
-
-
additional information
?
-
-
SSAO may contribute to the vascular damage associated to Alzheimer’s disease
-
-
-
additional information
?
-
synergistic interaction between semicarbazide-sensitive amine oxidase and angiotensin-converting enzyme in diabetes. Semicarbazide-sensitive amine oxidase is involved in the following biological processes: vision, inflammatory response, biogenic amine metabolism, catecholamine metabolism, amine metabolism, cell adhesion
-
-
-
additional information
?
-
semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
-
-
-
additional information
?
-
semicarbazide-sensitive amine oxidases constitute a group of copper-dependent enzymes, which oxidatively deaminate primary endo- and exogenous amines
-
-
-
additional information
?
-
AOC2 is an enzymatically active cell surface SSAO with distinct substrate specificity, the preferred in vitro substrates of AOC2 are 2-phenylethylamine, tryptamine and p-tyramine, cf. EC 1.4.3.4, instead of methylamine and benzylamine, the favored substrates of AOC3. Substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC2 with methylamine, polyamine spermidine, or histamine
-
-
-
additional information
?
-
AOC2 is an enzymatically active cell surface SSAO with distinct substrate specificity, the preferred in vitro substrates of AOC2 are 2-phenylethylamine, tryptamine and p-tyramine, cf. EC 1.4.3.4, instead of methylamine and benzylamine, the favored substrates of AOC3. Substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC2 with methylamine, polyamine spermidine, or histamine
-
-
-
additional information
?
-
substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC3 with polyamine spermidine or histamine
-
-
-
additional information
?
-
substrate docking, molecular modeling and comparison of AOC2 and AOC3, overview. No activity of AOC3 with polyamine spermidine or histamine
-
-
-
additional information
?
-
-
the catalytic center is deeply buried within the enzyme and is accessible only through a narrow channel with a diameter of about 4.5 A. This channel is gated by the side chain of L469 which, along with the copper-TPQ coordination, controls the catalytic activity of SSAO. While specific interactions with residues lining the surface of the accessing channel are important for substrate specificity, the flexibility of substrates also plays an important role, molecular dynamics and induced docking studies, detailed overview
-
-
-
additional information
?
-
-
VAP-1/SSAOs convert amines into aldehydes. SSAOs are distinct from the mammalian monoamine oxidases, MAOs, but their substrate specificities are partly overlapping
-
-
-
additional information
?
-
-
no activity with dimethylamide substituted indole 3-((4-[5-(aminomethyl)-2-fluorophenyl]piperidin-1-yl)carbonyl)-1-(2-methoxyethyl)-N,N-dimethyl-1H-indole-4-carboxamide
-
-
-
additional information
?
-
-
alkylamines 2-bromoethylamine and 2-chloroethylamine, and the short diamine 1,2-diaminoethane are both poor substrates and irreversible inactivators of LSAO
-
-
-
additional information
?
-
-
ethylenediamine and methylamine are no substrates for isoform AO2
-
-
-
additional information
?
-
-
T0901317 inhibits SSAO gene expression and its activity in atherogenic apoE-/- mice. The atheroprotective effect of LXR agonist T0901317 is related to the inhibition of SSAO gene expression and its activity
-
-
-
additional information
?
-
-
the catalytic mechanism can be divided into two half-reactions: a reductive half-reaction in which a primary amine substrate is oxidized to its corresponding aldehyde with the concomitant reduction of the organic cofactor 2,4,5-trihydroxyphenylalanine quinone and an oxidative half-reaction in which reduced 2,4,5-trihydroxyphenylalanine quinone is re-oxidized with the reduction of molecular oxygen to hydrogen peroxide
-
-
-
additional information
?
-
-
isoform HPAO-2 shows a clear preference for bulkier aromatic amines and isoform HPAO-1 shows a preference for short aliphatic amines
-
-
-
additional information
?
-
-
docking of substrates to the enzyme, the enzyme shows electrostatic control of the docking process, overview. The active site contains two negatively charged amino acid residues which seem to interact with positively charged groups of the substrate molecules
-
-
-
additional information
?
-
-
isoform AO1 isolated from butylamine-induced cells with a distinct specificity towards benzylamine (relative to phenylethylamine), acts on a broad range of aliphatic monoamines (C1-C5). Isoform AO2 isolated from phenylethylamine-treated cells displays activity towards phenylethylamine as well as tyramine and heterocyclic amines but negligible conversion of benzylamine and short chain aliphatic amines. Neither AO1 nor AO2 exhibit any measurable activity when using diamines (putrescine or cadaverine) as substrate
-
-
-
additional information
?
-
-
isoform AO1 isolated from butylamine-induced cells with a distinct specificity towards benzylamine (relative to phenylethylamine), acts on a broad range of aliphatic monoamines (C1-C5). Isoform AO2 isolated from phenylethylamine-treated cells displays activity towards phenylethylamine as well as tyramine and heterocyclic amines but negligible conversion of benzylamine and short chain aliphatic amines. Neither AO1 nor AO2 exhibit any measurable activity when using diamines (putrescine or cadaverine) as substrate
-
-
-
additional information
?
-
-
three histidine residues within the C-terminal region of Cao1 that are necessary for amine oxidase activity
-
-
-
additional information
?
-
-
three histidine residues within the C-terminal region of Cao1 that are necessary for amine oxidase activity
-
-
-
additional information
?
-
-
no activity with propylamine and hexylamine
-
-
-
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(1R,2S)-2-(1-methylhydrazino)-1-phenylbutan-1-ol
-
-
(1R,2S)-2-(1-methylhydrazino)-1-phenylpentan-1-ol
-
-
(1R,2S)-2-(1-methylhydrazino)-1-phenylpropan-1-ol
-
-
(2-methylprop-2-en-1-yl)hydrazine
-
-
(2-phenylprop-2-en-1-yl)hydrazine
(2E)-3-chloroprop-2-en-1-amine
-
-
(2E)-3-fluoro-4-phenoxybut-2-en-1-amine
-
-
(2E)-4-phenoxybut-2-en-1-amine
-
-
(2Z)-3-chloroprop-2-en-1-amine
-
-
(2Z)-3-fluoro-4-phenoxybut-2-en-1-amine
-
-
(2Z)-4-phenoxybut-2-en-1-amine
-
-
(4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]phenyl)(pyrrolidin-1-yl)methanone
-
-
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
1,4-diamino-2-chloro-2-butene
1,6-diamino-2,4-hexadiyne
1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-(1-methylhydrazino)-ethanol
-
-
1-(2,5-dihydro-1H-pyrrol-3-yl)isoquinoline
-
-
1-(2-(3-chlorophenyl)-2-methoxyethyl)-1-methylhydrazine
-
-
1-(2-chlorophenyl)-2-(1-methylhydrazino)ethanol
-
-
1-(2-phenylpropyl)hydrazine
-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
1-(3-methoxyphenyl)-2-(1-methylhydrazino)ethanol
-
-
1-(4-chlorophenyl)-2-(1-methylhydrazino)ethanol
-
-
1-(4-fluorophenyl)-2-(1-methylhydrazino)ethanol
-
-
1-(4-methoxyphenyl)-2-(1-methylhydrazino)ethanol
-
-
1-(isoquinolin-1-ylcarbonyl)pyrrolidine-2-carboxamide
-
-
1-benzyl-1-methylhydrazine
-
-
1-ethyl-1-(2-phenylethyl)hydrazine
-
-
1-ethyl-1-[2-(3,4,5-trimethoxyphenyl)ethyl]hydrazine
-
-
1-ethyl-1-[2-(4-methoxyphenyl)ethyl]hydrazine
-
-
1-ethyl-2-[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
-
1-isobutyl-1-(2-phenylethyl)hydrazine
-
-
1-isobutyl-1-[2-(4-methoxyphenyl)ethyl]hydrazine
-
-
1-methyl-1-(2-phenylethyl)hydrazine
-
-
1-methyl-1-(2-phenylpropyl)hydrazine
-
-
1-methyl-1-(3-phenylpropyl)hydrazine
-
-
1-[2-(2,3,4-trimethoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(2,5-dimethoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(2-chlorophenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(2-fluorophenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(2-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(3,4,5-trimethoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(3,4-dimethoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(3-chlorophenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(3-fluorophenyl)-2-methoxyethyl]-1-methylhydrazine
-
-
1-[2-(3-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(4-chlorophenyl)-2-methoxyethyl]-1-methylhydrazine
-
-
1-[2-(4-chlorophenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(4-fluorophenyl)-2-methoxyethyl]-1-methylhydrazine
-
-
1-[2-(4-fluorophenyl)ethyl]-1-methylhydrazine
-
-
1-[2-(4-fluorophenyl)prop-2-en-1-yl]-2-methylhydrazine
-
-
1-[2-(4-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-benzyloxy-2-(4-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-1-(3-tolyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-1-(4-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-2-(1-naphthyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-2-(2,3,4-trimethoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-2-(2-naphthyl)ethyl]-1-methylhydrazine
-
-
1-[2-methoxy-2-(3-methoxyphenyl)ethyl]-1-methylhydrazine
-
-
1-[3,5-bis(ethylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
-
1-[3,5-bis(tert-butylsulfanyl)pyridin-4-yl]methanamine dihydrochloride
-
-
1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
-
-
2,2-dimethyl-2-(1-methylhydrazino)-1-phenylethanol
-
-
2,6-bis(1-methylethoxy)benzylamine
-
-
2,6-bis(2-hydroxyethoxy)benzylamine
-
-
2,6-bis(3-hydroxypropoxy)benzylamine
-
-
2,6-bis(4-hydroxybutoxy)benzylamine
-
-
2,6-bis(ethoxymethyl)benzylamine
-
-
2,6-bis(methoxymethyl)benzylamine
-
-
2,6-dibutoxybenzylamine
-
-
2,6-dibutylbenzylamine
-
-
2,6-diethoxybenzylamine
-
-
2,6-diethylbenzylamine
-
-
2,6-dihydroxybenzylamine
-
-
2,6-dimethoxybenzylamine
-
-
2,6-dipropoxybenzylamine
-
-
2,6-dipropylbenzylamine
-
-
2-(1-isobutylhydrazino)-1-phenylethanol
-
-
2-(1-methylhydrazino)-1-(2,3,4-trimethoxyphenyl)ethanol
-
-
2-(1-methylhydrazino)-1-(2-naphthyl)ethanol
-
-
2-(1-methylhydrazino)-1-phenylethanol
-
-
2-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
-
-
2-(4-methoxyphenyl)-1-(1-methylhydrazino)-2-propanol
-
-
2-(4-[2-[2-(acetylamino)-2,3-dihydro-1,3-thiazol-4-yl]ethyl]phenyl)-N-[amino(imino)methyl]acetamide
-
-
2-(aminooxy)-1-(3,4-dimethoxyphenyl)ethanol
-
-
2-(aminooxy)-1-phenylethanol
-
-
2-(methylamino)ethanethiol
-
reversible inhibition
2-(methylthio)ethylamine
-
weak irreversible inhibitor
2-([[4-(1,1-dimethylpropyl)phenyl]sulfonyl]amino)-N,3-dihydroxybutanamide
-
-
2-amino-N-[2-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[2-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[3-fluoro-5-(trifluoromethyl)benzyl]acetamide
-
-
2-amino-N-[4-fluoro-3-(trifluoromethyl)benzyl]acetamide
-
-
2-ethylaminobenzylamine dihydrochloride
2-hydrazino-1-(3-methoxyphenyl)ethanol
-
-
2-hydrazino-1-(4-methoxyphenyl)ethanol
-
-
2-hydrazino-1-phenylethanol
-
-
2-hydroxymethylbenzylamine
-
-
2-methylaminobenzylamine dihydrochloride
2-[(biphenyl-4-ylacetyl)amino]pentanedioic acid
-
-
3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
-
-
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
3-(2,5-dihydro-1H-pyrrol-3-yl)pyridine
-
-
3-(2-naphthyl)-3-pyrroline
-
0.2 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-(4-methoxy-3-nitrophenyl)-3-pyrroline
-
0.015 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrole hydrochloride
-
0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-(4-methoxyphenyl)-N-methyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
3-amino-4-aminomethylpyridine dihydrochloride
-
-
3-aminopropanethiol
-
reversible inhibition
3-biphenyl-4-yl-2,5-dihydro-1H-pyrrole hydrochloride
-
0.1 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-bromoprop-2-yn-1-amine
-
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
3-ethylamino-4-aminomethylpyridine dihydrochloride
3-methylamino-4-aminomethylpyridine dihydrochloride
3-naphthalen-1-yl-2,5-dihydro-1H-pyrrole hydrochloride
-
0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-phenyl-3-pyrroline
-
0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
3-[2-(3-methoxyphenyl)ethyl]-2,5-dihydro-1H-pyrrole
-
-
4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
-
-
4-(2,5-dihydro-1H-pyrrol-3-yl)-N,N-dimethylaniline hydrochloride
-
0.4 mM, inactivation of BPAO by 3-aryl-3-pyrrolines
4-(2-naphthyloxy)but-2-yn-1-amine
-
-
4-(4-methoxyphenoxy)but-2-yn-1-amine
-
-
4-(4-methylphenoxy)but-2-yn-1-amine
-
-
4-(4-nitrophenoxy)but-2-yn-1-amine
-
-
4-(aminomethyl)-2-benzyl-5-(ethylamino)pyridazin-3(2H)-one
-
below 10% inhibition at 0.5 mM
4-(aminomethyl)-2-methyl-5-(morpholin-4-yl)pyridazin-3(2H)-one
-
93% inhibition at 0.5 mM
4-(aminomethyl)-2-methyl-5-(pyrrolidin-1-yl)pyridazin-3(2H)-one
-
below 10% inhibition at 0.5 mM
4-(aminomethyl)-5-(ethylamino)-2-methylpyridazin-3(2H)-one
-
13% inhibition at 0.5 mM
4-(aminomethyl)-N,N-diethylpyridazine-3,5-diamine
-
over 99% inhibition at 0.5 mM
4-(aminomethyl)-N,N'-bis(1-methylethyl)pyridine-3,5-diamine dihydrochloride
-
-
4-(aminomethyl)-N,N'-dibutylpyridine-3,5-diamine dihydrochloride
-
-
4-(aminomethyl)-N,N'-diethylpyridazine-3,5-diamine
-
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
4-(aminomethyl)-N-butylpyridazin-3-amine
-
27% inhibition at 0.5 mM
4-(aminomethyl)-N-ethylpyridazin-3-amine
-
29% inhibition at 0.5 mM
4-(aminomethyl)-N-methylpyridazin-3-amine
-
47% inhibition at 0.5 mM
4-(aminomethyl)-N-methylpyridine-3,5-diamine dihydrochloride
-
-
4-(aminomethyl)-N-propylpyridazin-3-amine
-
44% inhibition at 0.5 mM
4-amino-3-hydroxy-N-(3-phenylpropyl)benzamide
-
-
4-aminobut-2-ynenitrile
-
-
4-bromo-N-[2-(hydroxyamino)-2-oxoethyl]benzamide
-
-
4-hydroxybenzylhydrazine
-
-
4-phenoxybut-2-yn-1-amine
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N,N-dimethylbenzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-(1-phenylethyl)benzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzyl-N-methylbenzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-benzylbenzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclohexylbenzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]-N-cyclopentylbenzamide
-
-
4-[[(2E)-4-amino-2-fluorobut-2-en-1-yl]oxy]benzamide
-
-
5-amino-2-hydroxy-N-(3-phenylpropyl)benzamide
-
-
alkylamino derivatives of 4-aminomethylpyridine
-
-
-
amikacin
-
about 60% residual activity at 1 mM
Br-
-
uncompetitive inhibitor with respect to the substrate amine and noncompetitive inhibitor with respect to dissolved oxygen
buta-2,3-dien-1-amine
-
-
Cl-
-
uncompetitive inhibitor with respect to the substrate amine and noncompetitive inhibitor with respect to dissolved oxygen
CuCl2
-
strong inhibition at 1 mM
cysteamine
-
reversible inhibition
EDTA
-
treatment with EDTA reduces the activity of wild type enzyme
extract from Taiwanofungus camphoratus
-
F-
-
uncompetitive inhibitor with respect to the substrate amine and noncompetitive inhibitor with respect to dissolved oxygen
geraniin
-
competitive inhibition. Inhibitory activities of 10.87%, 37.24%, 77.67%, and 95.77%, respectively, for 0.00066, 0.00164, 0.00328, and 0.00656 mM of geraniin
histamine
substrate inhibition; substrate inhibition
hydrazine
-
complete inhibition at 1 mM
I-
-
uncompetitive inhibitor with respect to the substrate amine and noncompetitive inhibitor with respect to dissolved oxygen
Iproniazid
-
nearly complete inhibition at 1 mM
kanamycin
-
about 70% residual activity at 1 mM
KCl
-
100 mM, 88% inhibition of dimeric and tetrameric enzyme
L-Lys
-
the presence of L-lysine during the oxidation of benzylamine results in time- and dose-dependent inhibition of SSAO activity, in a process that is dependent on the H2O2 formed during benzylamine oxidation
N,3-dihydroxy-2-[(2-naphthylsulfonyl)amino]butanamide
-
-
N-allyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
N-ethyl-3-(4-methoxyphenyl)-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
-
-
N-[2-(hydroxyamino)-2-oxoethyl]-2-(2-methyl-1H-indol-3-yl)acetamide
-
-
N-[4-(2-[4-[(2-amino-1H-imidazol-5-yl)methyl]phenyl]ethyl)-1,3-thiazol-2-yl]acetamide
-
-
N-[4-[2-(4-carbamimidamidophenyl)ethyl]-5-(4-sulfamoylbenzyl)-1,3-thiazol-2-yl]acetamide
-
-
N-[4-[2-(4-[[amino(imino)methyl]amino]phenyl)ethyl]-1,3-thiazol-2-yl]acetamide
-
-
N6-(4-aminobut-2-ynyl)adenine
NaCl
-
100 mM, 88% inhibition of dimeric and tetrameric enzyme
Neocuproine
-
0.033 mM, 61% inhibition
nitric oxide
-
irreversible inhibitor
o-phenylenediamine
-
0.2 mM, 33% inhibition of dimeric enzyme, 26% inhibition of tetrameric enzyme
p-chloromercuriphenylsulfonate
-
0.1 mM, complete inhibition of enzyme from cultured aortic smooth muscle cells
rasagiline ethanedisulfonate
-
inhibits MAO-B
ruthenium(II) molecular wires
-
the enzyme is reversibly inhibited by molecular wires comprising a Ru(II) complex head group and an aromatic tail group joined by an alkane linker
-
sisomycin
-
about 45% residual activity at 1 mM
Sodium thioglycolate
-
slight
tobramycin
-
about 40% residual activity at 1 mM
[(2E)-3-fluoro-2-phenylprop-2-en-1-yl]hydrazine
-
-
[2-(2-methylphenyl)prop-2-en-1-yl]hydrazine
-
-
[2-(4-chlorophenyl)prop-2-en-1-yl]hydrazine
-
-
[2-(4-fluorophenyl)prop-2-en-1-yl]hydrazine
-
-
(2-phenylprop-2-en-1-yl)hydrazine

-
-
(2-phenylprop-2-en-1-yl)hydrazine
-
-
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride

-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
(Z)-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride
-
i.e. LJP 1586. Potent, specific, and orally available inhibitor of SSAO activity is an effective anti-inflammatory compound in vivo
1,4-diamino-2-butyne

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-butyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-butyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-butyne
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-chloro-2-butene

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-chloro-2-butene
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-chloro-2-butene
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-diamino-2-chloro-2-butene
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,4-phenanthroline

-
0.0075 mM, 41% inhibition
1,4-phenanthroline
-
0.33 mM, 65% inhibition
1,5-diamino-2-pentyne

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,5-diamino-2-pentyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,5-diamino-2-pentyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,5-diamino-2-pentyne
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,6-diamino-2,4-hexadiyne

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,6-diamino-2,4-hexadiyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,6-diamino-2,4-hexadiyne
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1,6-diamino-2,4-hexadiyne
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride

-
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
-
-
2-Bromoethylamine

-
-
2-Bromoethylamine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
2-Bromoethylamine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
2-Bromoethylamine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
2-Bromoethylamine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
2-Bromoethylamine
-
irreversible inhibitor
2-ethylaminobenzylamine dihydrochloride

-
-
2-ethylaminobenzylamine dihydrochloride
-
2-ethylaminobenzylamine dihydrochloride
-
-
2-methylaminobenzylamine dihydrochloride

-
-
2-methylaminobenzylamine dihydrochloride
-
2-methylaminobenzylamine dihydrochloride
-
-
2-Phenylethylamine

substrate inhibition
2-Phenylethylamine
; substrate inhibition
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
3,3-bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate

-
-
3-(1-piperidinyl)-4-aminomethylpyridine dihydrochloride hemihydrate
-
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate

-
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cycloheptylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate

-
-
3-cyclohexylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate

-
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
3-cyclohexylmethylamino-4-aminomethylpyridine dihydrochloride monohydrate
-
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate

-
-
3-cyclopentylamino-4-aminomethylpyridine dihydrochloride hemihydrate
-
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate

-
-
3-cyclopropylamino-4-aminomethylpyridine dihydrochloride sesquihydrate
-
-
3-ethylamino-4-aminomethylpyridine dihydrochloride

-
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
3-ethylamino-4-aminomethylpyridine dihydrochloride
-
-
3-methylamino-4-aminomethylpyridine dihydrochloride

-
-
3-methylamino-4-aminomethylpyridine dihydrochloride
-
3-methylamino-4-aminomethylpyridine dihydrochloride
-
-
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride

-
-
3-[(1-methylethyl)amino]-4-aminomethylpyridine dihydrochloride
-
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride

-
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-diethylpyridine-3,5-diamine dihydrochloride
-
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride

-
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
4-(aminomethyl)-N,N'-dimethylpyridine-3,5-diamine dihydrochloride
-
-
8-hydroxyquinoline

non-competitive inhibitor; non-competitive inhibitor; non-competitive inhibitor
8-hydroxyquinoline
-
strong inhibition at 1 mM
8-hydroxyquinoline
-
0.0075 mM, 27% inhibition
aminoguanidine

irreversible competitive inhibitor; irreversible competitive inhibitor; irreversible competitive inhibitor
aminoguanidine
irreversible inhibition
aminoguanidine
-
strongly inhibits adipocyte semicarbazide-sensitive amine oxidase and slightly reduces fat deposition in obese Zucker rats. Aminoguanidine may be useful for treating obesity via its SSAO blocking properties
aminoguanidine
-
isoform AO1 shows 18% residual activity at 0.1 mM, isoform AO2 shows 17% residual activity at 0.1 mM
aminoguanidine
-
irreversible inhibitor
benzylamine

substrate inhibition
benzylhydrazine

-
forms adducts with the TPQ cofactor, binding structure, overview
Cuprizone

-
copper chelating, 0.006 mM, 98% inhibition, competitive vs. benzylamine
Cuprizone
-
isoform AO1 shows 2% residual activity at 0.1 mM, isoform AO2 shows 1% residual activity at 0.1 mM
Cuprizone
-
competitive binding to enzyme copper is suggested
cyanide

-
0.1 mM, 76% inhibition
cyanide
-
uncompetitive vs. benzylamine, non-competititve vs. O2
diethyldithiocarbamate

-
3.3 mM, 74% inhibition
diethyldithiocarbamate
-
no inhibition
extract from Taiwanofungus camphoratus

-
-
-
extract from Taiwanofungus camphoratus
-
-
-
hydroxylamine

-
complete inhibition at 1 mM
hydroxylamine
-
elicits hypotension in the rat. This effect is due in part to its conversion to nitric oxide and in part to a hydralazine-like action involving SSAO inhibition
hydroxylamine
-
3.3 mM, 30% inhibition
isoniazid

-
nearly complete inhibition at 1 mM
isoniazid
-
0.2 mM, 42% inhibition of dimeric enzyme, 39% inhibition of tetrameric enzyme
isoniazid
-
isoform AO1 shows 14% residual activity at 0.1 mM, isoform AO2 shows 16% residual activity at 0.1 mM
N6-(4-aminobut-2-ynyl)adenine

during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
N6-(4-aminobut-2-ynyl)adenine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
N6-(4-aminobut-2-ynyl)adenine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
N6-(4-aminobut-2-ynyl)adenine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
NaN3

-
3.3 mM, 48% inhibition
NaN3
-
uncompetitive inhibition
NaN3
-
azide binds to Cu2+ ions, competitive inhibition vs. O2, uncompetitive vs. benzylamine
Phenelzine

-
-
Phenelzine
-
0.001 mM, complete inhibition of enzyme from cultured aortic smooth muscle cells
phenylhydrazine

-
-
phenylhydrazine
-
complete inhibition at 1 mM
phenylhydrazine
-
irreversible inactivation most likely due to hydrazone formation
Semicarbazide

-
nearly complete inhibition at 1 mM
Semicarbazide
-
0.2 mM, 49% inhibition of dimeric enzyme, 45% inhibition of tetrameric enzyme
Semicarbazide
causes significant decreases in the oxidative deamination activity of four among the five substrates catalyzed by SSAO
Semicarbazide
-
irreversible inhibitor. Pargyline + semicarbazide-induced reduction of fat deposition results from decreased food intake and from impaired MAO (EC 1.4.3.4) and SSAO-dependent lipogenic and antilipolytic actions of endogenous or alimentary amines
Semicarbazide
-
isoform AO1 shows 1% residual activity at 0.1 mM, isoform AO2 shows 2% residual activity at 0.1 mM
Semicarbazide
-
0.01 mM, complete inhibition of enzyme from cultured aortic smooth muscle cells
tranylcypromine

-
forms adducts with the TPQ cofactor, also termed (1R,2S)-rel-2-phenylcyclopropanamine, is a mixture of (1R,2S)-2-phenylcyclopropanamine and (1S,2R)-2-phenylcyclopropanamine, binding structure, overview
tranylcypromine
-
fully reversible competitive onhibitor
tryptamine

substrate inhibition
tryptamine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tryptamine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tryptamine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tryptamine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tyramine

-
irreversible inhibitor
tyramine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tyramine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tyramine
-
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
tyramine
substrate inhibition; substrate inhibition
tyramine
during the oxidation of these suicide substrates, the reversible formation of an enzyme-killer product complex occurs followed by an irreversible inactivation of the enzyme, typical of mechanism-based inactivation
additional information

-
not inhibited by MgCl2, MnCl2, CoCl2, ZnCl2, FeCl3, sodium azide, N-ethylmaleimide, and iodoacetate
-
additional information
-
3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases
-
additional information
-
not inhibited by 2-aminoethanol and 2-(N,N-dimethylamino)ethanethiol
-
additional information
-
not inhibited by gentamycin
-
additional information
-
inhibitor synthesis and screening, overview
-
additional information
-
synthesis and in vitro activities of a series of VAP-1 selective inhibitors, molecular dynamics simulations and docking studies, pIC50 values, overview. Movements of Met211, Ser496, and especially Leu469 can enlarge the ligand-binding pocket, allowing larger ligands than those seen in the crystal structures to bind. Three-dimensional quantitative structure-activity relationship models for VAP-1 in comparison to MAOs, overview
-
additional information
-
no effect: DTT or EDTA at 1 mM, 1,4-diamino-2-butanone, sodium azide or KCN
-
additional information
the enzyme activity is not significantly affected in the presence of 5 mM EDTA; the enzyme activity is not significantly affected in the presence of 5 mM EDTA
-
additional information
the enzyme activity is not significantly affected in the presence of 5 mM EDTA; the enzyme activity is not significantly affected in the presence of 5 mM EDTA
-
additional information
-
the enzyme activity is not significantly affected in the presence of 5 mM EDTA; the enzyme activity is not significantly affected in the presence of 5 mM EDTA
-
additional information
clorgyline and deprenyl do not significantly inhibit the activities
-
additional information
-
no inhibition by pargyline. SSAO activity remains unchanged during starvation
-
additional information
-
not inhibited by pargyline, clorgyline, and neocupine
-
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