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L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
L-ornithine + O2 + H2O
? + H2O2 + NH3
15.1% activity compared to L-lysine
-
-
?
alpha-N-acetyl-L-lysine + H2O
N-acetyl-6-oxo-L-norleucine + H2O2 + NH3
-
91.9% of the activity with L-lysine
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
L-lysine + O2 + H2O2
2-aminoadipate 6-semialdehyde + NH3 + H2O2
-
-
-
-
?
L-ornithine + O2 + 2 H2O
(2S)-2-hydroxy-5-oxopentanoate + 2 NH3 + H2O2
-
3.2% activity compared to L-lysine
-
-
?
L-ornithine + O2 + H2O
5-oxo-L-norvaline + H2O2 + NH3
-
15.1% of activity with L-lysine
-
-
?
additional information
?
-
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
?
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
-
?
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
?
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
100% activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
100% activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
the enzyme shows antibacterial activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
-
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
100% activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
high stereospecificity for L-lysine
-
-
?
additional information
?
-
no activity with L-arginine and meso-2,6-diaminopimelic acid
-
-
?
additional information
?
-
-
no activity with L-arginine and meso-2,6-diaminopimelic acid
-
-
?
additional information
?
-
alternative electron acceptors like 2,6-dichloroinophenol, ferricyanide, NAD+, amicyanin or cytochrome C-550 cannot effectively substitute for O2 in the reaction
-
-
?
additional information
?
-
-
the enzyme shows antibacterial activity
-
-
?
additional information
?
-
-
no activity with morpholinepropanesulfonic acid, trehalose, and tricine
-
-
?
additional information
?
-
-
no activity with L-phenylalanine, L-arginine, L-tyrosine, L-histidine, and L-leucine
-
-
?
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L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
L-ornithine + O2 + 2 H2O
(2S)-2-hydroxy-5-oxopentanoate + 2 NH3 + H2O2
-
3.2% activity compared to L-lysine
-
-
?
additional information
?
-
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
?
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
-
?
L-lysine + O2 + H2O
(S)-2-amino-6-oxohexanoate + H2O2 + NH3
-
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
100% activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
the enzyme shows antibacterial activity
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
-
-
-
?
L-lysine + O2 + H2O
2-aminoadipate 6-semialdehyde + H2O2 + NH3
-
100% activity
-
-
?
additional information
?
-
no activity with L-arginine and meso-2,6-diaminopimelic acid
-
-
?
additional information
?
-
-
no activity with L-arginine and meso-2,6-diaminopimelic acid
-
-
?
additional information
?
-
-
no activity with L-phenylalanine, L-arginine, L-tyrosine, L-histidine, and L-leucine
-
-
?
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Lucas-Elio, P.; Hernandez, P.; Sanchez-Amat, A.; Solano, F.
Purification and partial characterization of marinocine, a new broad-spectrum antibacterial protein produced by Marinomonas mediterranea
Biochim. Biophys. Acta
1721
193-203
2005
Marinomonas mediterranea
brenda
Gomez, D.; Lucas-Elio, P.; Sanchez-Amat, A.; Solano, F.
A novel type of lysine oxidase: L-lysine-epsilon-oxidase
Biochim. Biophys. Acta
247; 1764
1577-1585
2006
Marinomonas mediterranea
brenda
Lucas-Elio, P.; Gomez, D.; Solano, F.; Sanchez-Amat, A.
The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity
J. Bacteriol.
188
2493-2501
2006
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea
brenda
Mai-Prochnow, A.; Lucas-Elio, P.; Egan, S.; Thomas, T.; Webb, J.S.; Sanchez-Amat, A.; Kjelleberg, S.
Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria
J. Bacteriol.
190
5493-5501
2008
Caulobacter vibrioides, Chromobacterium violaceum, Marinomonas mediterranea, Pseudoalteromonas tunicata
brenda
Okazaki, S.; Nakano, S.; Matsui, D.; Akaji, S.; Inagaki, K
Asano, Y.: X-Ray crystallographic evidence for the presence of the cysteine tryptophylquinone cofactor in L-lysine {varepsilon}-oxidase from Marinomonas mediterranea
J. Biochem.
154
233-236
2013
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda
Matsuda, M.; Asano, Y.
Determination of plasma and serum L-lysine using L-lysine epsilon-oxidase from Marinomonas mediterranea NBRC 103028T
Anal. Biochem.
406
19-23
2010
Marinomonas mediterranea, Marinomonas mediterranea NBRC 103028T
brenda
Molina-Quintero, L.R.; Lucas-Elio, P.; Sanchez-Amat, A.
Regulation of the Marinomonas mediterranea antimicrobial protein lysine oxidase by L-lysine and the sensor histidine kinase PpoS
Appl. Environ. Microbiol.
76
6141-6149
2010
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea, Marinomonas mediterranea MMB-1 (F2JXJ3)
brenda
Gomez, D.; Lucas-Elio, P.; Solano, F.; Sanchez-Amat, A.
Both genes in the Marinomonas mediterranea lodAB operon are required for the expression of the antimicrobial protein lysine oxidase
Mol. Microbiol.
75
462-473
2010
Marinomonas mediterranea, Marinomonas mediterranea MMB-1
brenda
Sehanobish, E.; Chacon-Verdu, M.D.; Sanchez-Amat, A.; Davidson, V.L.
Roles of active site residues in LodA, a cysteine tryptophylquinone dependent epsilon-lysine oxidase
Arch. Biochem. Biophys.
579
26-32
2015
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda
Chacon-Verdu, M.D.; Campillo-Brocal, J.C.; Lucas-Elio, P.; Davidson, V.L.; Sanchez-Amat, A.
Characterization of recombinant biosynthetic precursors of the cysteine tryptophylquinone cofactors of l-lysine-epsilon-oxidase and glycine oxidase from Marinomonas mediterranea
Biochim. Biophys. Acta
1854
1123-1131
2015
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea, Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda
Matsui, D.; Asano, Y.
Heterologous production of L-lysine epsilon-oxidase by directed evolution using a fusion reporter method
Biosci. Biotechnol. Biochem.
79
1473-1480
2015
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda
Sehanobish, E.; Shin, S.; Sanchez-Amat, A.; Davidson, V.L.
Steady-state kinetic mechanism of LodA, a novel cysteine tryptophylquinone-dependent oxidase
FEBS Lett.
588
752-756
2014
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda
Okazaki, S.; Nakano, S.; Matsui, D.; Akaji, S.; Inagaki, K.; Asano, Y.
X-ray crystallographic evidence for the presence of the cysteine tryptophylquinone cofactor in L-lysine alpha-oxidase from Marinomonas mediterranea
J. Biochem.
154
233-236
2013
Marinomonas mediterranea (F2JXJ3), Marinomonas mediterranea NBRC 103028 (F2JXJ3)
brenda