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Information on EC 1.4.3.2 - L-amino-acid oxidase and Organism(s) Gloydius blomhoffii and UniProt Accession Q90W54

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EC Tree
     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.2 L-amino-acid oxidase
IUBMB Comments
A flavoprotein (FAD).
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Select one or more organisms in this record:
This record set is specific for:
Gloydius blomhoffii
UNIPROT: Q90W54
Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
The taxonomic range for the selected organisms is: Gloydius blomhoffii
Synonyms
AAD, ACTX-6, ACTX-8, Akbu-LAAO, APIT, aromatic L-amino acid oxidase, Balt-LAAO-I, Bpir-LAOO-1, DAA, Dolabellanin, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aromatic L-amino acid oxidase
-
-
-
-
L-amino acid oxidase
-
-
-
-
L-amino acid:O2 oxidoreductase
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-
-
-
L-aminooxidase
-
-
-
-
LAAO
-
-
-
-
LAO
-
-
-
-
M-LAO
ophio-amino-acid oxidase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidative deamination
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-
-
-
redox reaction
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-amino-acid:oxygen oxidoreductase (deaminating)
A flavoprotein (FAD).
CAS REGISTRY NUMBER
COMMENTARY hide
9000-89-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
DL-norleucine + H2O + O2
2-oxocaproate + NH3 + H2O2
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
flavin
LAO is a flavoenzyme
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
m-chlorobenzoate
LAO inhibitor, does not inhibit the degradation of fibrinogen
o-aminobenzoic acid
LAO inhibitor, slightly inhibiting the degradation of fibrinogen
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pI VALUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
OXLA_GLOBL
504
0
57092
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
60000
x * 60000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 60000, SDS-PAGE
POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
native enzyme by gel filtration, cation and anion exchange chromatography, and hydroxyapatite chromatography
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Du, X.Y.; Clemetson, K.J.
Snake venom L-amino acid oxidases
Toxicon
40
659-665
2002
Agkistrodon contortrix laticinctus, Bothrops moojeni, Calloselasma rhodostoma, Crotalus adamanteus, Crotalus atrox, Eristicophis macmahoni, Gloydius blomhoffii, Naja kaouthia, Ophiophagus hannah, Protobothrops flavoviridis, Protobothrops mucrosquamatus, Pseudechis australis, snake
Manually annotated by BRENDA team
Sakurai, Y.; Shima, M.; Matsumoto, T.; Takatsuka, H.; Nishiya, K.; Kasuda, S.; Fujimura, Y.; Yoshioka, A.
Anticoagulant activity of M-LAO, L-amino acid oxidase purified from Agkistrodon halys blomhoffii, through selective inhibition of factor IX
Biochim. Biophys. Acta
1649
51-57
2003
Gloydius blomhoffii
Manually annotated by BRENDA team
Fujisawa, D.; Yamazaki, Y.; Morita, T.
Re-evaluation of M-LAO, L-amino acid oxidase, from the venom of Gloydius blomhoffi as an anticoagulant protein
J. Biochem.
146
43-49
2009
Gloydius blomhoffii, Gloydius blomhoffii (Q90W54)
Manually annotated by BRENDA team
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