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Information on EC 1.4.3.2 - L-amino-acid oxidase and Organism(s) Bungarus fasciatus and UniProt Accession A8QL52

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     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.2 L-amino-acid oxidase
IUBMB Comments
A flavoprotein (FAD).
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This record set is specific for:
Bungarus fasciatus
UNIPROT: A8QL52
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Word Map
The taxonomic range for the selected organisms is: Bungarus fasciatus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
laao, il4i1, l-amino-acid oxidase, l-aao, escapin, head kidney and gill, dolabellanin, l-phenylalanine oxidase, akbu-laao, m-lao, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aromatic L-amino acid oxidase
-
-
-
-
L-amino acid oxidase
-
-
-
-
L-amino acid:O2 oxidoreductase
-
-
-
-
L-aminooxidase
-
-
-
-
LAO
-
-
-
-
ophio-amino-acid oxidase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
-
-
-
-
oxidative deamination
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-amino-acid:oxygen oxidoreductase (deaminating)
A flavoprotein (FAD).
CAS REGISTRY NUMBER
COMMENTARY hide
9000-89-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-Ala + H2O + O2
2-oxopropanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Asn + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Gln + H2O + O2
5-amino-2,5-dioxopentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Leu + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Lys + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Met + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Trp + H2O + O2
indole-3-pyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-Arg + H2O + O2
2-oxo-5-guanidinovaleric acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Glu + H2O + O2
2-oxoglutarate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Ile + H2O + O2
3-methyl-2-oxo-pentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Leu + H2O + O2
2-oxo-4-methylvaleric acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Met + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Trp + H2O + O2
indole-3-pyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
LAAO exhibits a cytotoxic effect on A549 cells and causes up to 41.2% apoptosis of A549 cells, overview
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
28.3
L-Ala
-
pH 8.5, 25°C
18.75
L-Arg
-
pH 8.5, 25°C
19.07
L-Asn
-
pH 8.5, 25°C
0.04
L-Asp
-
pH 8.5, 25°C
5.88
L-Gln
-
pH 8.5, 25°C
1.44
L-Glu
-
pH 8.5, 25°C
4.84
L-His
-
pH 8.5, 25°C
1.64
L-Ile
-
pH 8.5, 25°C
60.69 - 60.7
L-Leu
21.5
L-Lys
-
pH 8.5, 25°C
15 - 15.03
L-Met
0.13 - 84.08
L-Phe
0.27
L-Trp
0.05
L-Tyr
-
pH 8.5, 25°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
293
L-Ala
-
pH 8.5, 25°C
228.8
L-Arg
-
pH 8.5, 25°C
84.08
L-Asn
-
pH 8.5, 25°C
47.49
L-Asp
-
pH 8.5, 25°C
430.4
L-Gln
-
pH 8.5, 25°C
790.5
L-Glu
-
pH 8.5, 25°C
483.1
L-His
-
pH 8.5, 25°C
66.7
L-Ile
-
pH 8.5, 25°C
1025 - 1025.05
L-Leu
318.9
L-Lys
-
pH 8.5, 25°C
589.3 - 589.93
L-Met
142.6 - 142.62
L-Phe
98.82
L-Trp
100.6
L-Tyr
-
pH 8.5, 25°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
8.5
-
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
25
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
the enzyme exhibits cytotoxic, bactericidal, leishmanicidal, and antiviral effects
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
OXLA_BUNFA
517
0
58764
Swiss-Prot
Secretory Pathway (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
55000
-
1 * 55000, SDS-PAGE
70000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodimer
-
2 * 55000, SDS-PAGE
monomer
-
1 * 55000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native enzyme from venom by anion exchange and heparin affinity chromatography
-
SP-Sepharose column chromatography and heparin-Sepharose column chromatography
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jin, Y.; Lee, W.H.; Zeng, L.; Zhang, Y.
Molecular characterization of L-amino acid oxidase from king cobra venom
Toxicon
50
479-489
2007
Bungarus fasciatus (A8QL52), Bungarus fasciatus, Bungarus multicinctus (A8QL51), Bungarus multicinctus, Naja atra (A8QL58), Naja atra, Ophiophagus hannah (P81383), Ophiophagus hannah
Manually annotated by BRENDA team
Wei, J.F.; Yang, H.W.; Wei, X.L.; Qiao, L.Y.; Wang, W.Y.; He, S.H.
Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venom
Toxicon
54
262-271
2009
Bungarus fasciatus
Manually annotated by BRENDA team
Izidoro, L.F.; Sobrinho, J.C.; Mendes, M.M.; Costa, T.R.; Grabner, A.N.; Rodrigues, V.M.; da Silva, S.L.; Zanchi, F.B.; Zuliani, J.P.; Fernandes, C.F.; Calderon, L.A.; Stabeli, R.G.; Soares, A.M.
Snake venom L-amino acid oxidases trends in pharmacology and biochemistry
BioMed Res. Int.
2014
196754
2014
Deinagkistrodon acutus, Calloselasma rhodostoma, Bothrops atrox, Bothrops jararaca, Bothrops marajoensis, Bungarus fasciatus, Lachesis muta, Naja oxiana, Ophiophagus hannah, Daboia russelii, Macrovipera lebetina, Bothrops alternatus, Bothrops pirajai, Gloydius ussuriensis, Bungarus caeruleus, Aplysia punctata, Bothrops insularis, Bothrops pauloensis, Crotalus durissus cumanensis, Bothrops leucurus, Vipera berus berus
Manually annotated by BRENDA team