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EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Synonyms
nadp-gdh, nadp-dependent glutamate dehydrogenase, nadp-glutamate dehydrogenase, nadp-specific glutamate dehydrogenase, nadp-linked glutamate dehydrogenase, nadph-dependent glutamate dehydrogenase, nadp+-dependent glutamate dehydrogenase, glutamate dehydrogenase (nadp+), nadp+-dependent gdh, nadp-dependent gdh,
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dehydrogenase, glutamate (nicotinamide adenine dinucleotide phosphate)
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glutamic acid dehydrogenase
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glutamic dehydrogenase
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L-glutamate dehydrogenase
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NAD(P)H-dependent glutamate dehydrogenase
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oxidative deamination
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reductive amination
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L-glutamate:NADP+ oxidoreductase (deaminating)
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L-glutamate + H2O + NADP+
2-oxoglutarate + NH3 + NADPH + H+
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2-hydroxyethyl disulfide
attenuation of reductive amination (forward) activity but a negligible effect on oxidative deamination (reverse) activity
cystine
strongly and selectively inhibits the reductive amination reaction
additional information
not inhibitory/activating: oxidized glutathione
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additional information
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not inhibitory/activating: oxidized glutathione
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Dehydration
Over-expression of a glutamate dehydrogenase gene, MgGDH, from Magnaporthe grisea confers tolerance to dehydration stress in transgenic rice.
Infections
Regulation and differential expression of gdhA encoding NADP-specific glutamate dehydrogenase in Neisseria meningitidis clinical isolates.
Starvation
[Features of the interconversion of alpha-ketoglutarate--glutamate in brain mitochondria of exothermic animals during hibernation]
Starvation
[Glutamate dehydrogenases of unicellular green algae: effects of nitrate and ammonium in vivo]
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4
2-oxoglutarate
mutant C141S, S0.5 value, Hill coefficient 2.3, pH 8.0, temperature not specified in the publication
4.78
2-oxoglutarate
wild-type, S0.5 value, Hill coefficient 3.2, pH 8.0, temperature not specified in the publication
5.7
2-oxoglutarate
recombinant wild-type, S0.5 value, Hill coefficient 3.5, pH 8.0, temperature not specified in the publication
15.5
2-oxoglutarate
mutant C415S, S0.5 value, Hill coefficient 4.9, pH 8.0, temperature not specified in the publication
25.1
2-oxoglutarate
wild-type inactivated by 2-hydroxyethyl disulfide, S0.5 value, Hill coefficient 2.4, pH 8.0, temperature not specified in the publication
28.6
L-glutamate
mutant C141S, pH 9.3, temperature not specified in the publication
30.9
L-glutamate
recombinant wild-type, pH 9.3, temperature not specified in the publication
34.6
L-glutamate
wild-type, pH 9.3, temperature not specified in the publication
36.8
L-glutamate
mutant C415S, pH 9.3, temperature not specified in the publication
49.8
L-glutamate
wild-type inactivated by 2-hydroxyethyl disulfide, S0.5 value, Hill coefficient 1.9, pH 9.3, temperature not specified in the publication
0.017
NADP+
wild-type, pH 9.3, temperature not specified in the publication
0.022
NADP+
wild-type inactivated by 2-hydroxyethyl disulfide, pH 9.3, temperature not specified in the publication
0.028
NADP+
recombinant wild-type, pH 9.3, temperature not specified in the publication
0.011
NADPH
wild-type, pH 8.0, temperature not specified in the publication
0.023
NADPH
recombinant wild-type, pH 8.0, temperature not specified in the publication
0.044
NADPH
wild-type inactivated by 2-hydroxyethyl disulfide, pH 8.0, temperature not specified in the publication
1.05
NH3
wild-type, pH 8.0, temperature not specified in the publication
1.1
NH3
recombinant wild-type, pH 8.0, temperature not specified in the publication
1.2
NH3
mutant C141S, pH 8.0, temperature not specified in the publication
2.6
NH3
wild-type inactivated by 2-hydroxyethyl disulfide, pH 8.0, temperature not specified in the publication
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UniProt
brenda
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B6V7E4_ASPNG
460
0
49391
TrEMBL
Chloroplast (Reliability: 2)
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C141S
reductive amination activity of C141S alone is insensitive to treatment with 2-hydroxyethyl disulfide
C415S
mutant loses its reductive amination activity in a manner very similar to the native enzyme
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expression in Escherichia coli
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Walvekar, A.S.; Choudhury, R.; Punekar, N.S.
Mixed disulfide formation at Cys141 leads to apparent unidirectional attenuation of Aspergillus niger NADP-glutamate dehydrogenase activity
PLoS ONE
9
e101662
2014
Aspergillus niger (B6V7E4), Aspergillus niger
brenda