Information on EC 1.4.1.24 - 3-dehydroquinate synthase II

for references in articles please use BRENDA:EC1.4.1.24
Word Map on EC 1.4.1.24
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The expected taxonomic range for this enzyme is: Bacteria, Archaea

EC NUMBER
COMMENTARY hide
1.4.1.24
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RECOMMENDED NAME
GeneOntology No.
3-dehydroquinate synthase II
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REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+ = 3-dehydroquinate + NH3 + NADH + H+
show the reaction diagram
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-dehydroquinate biosynthesis II (archaea)
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chorismate metabolism
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Phenylalanine, tyrosine and tryptophan biosynthesis
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Biosynthesis of secondary metabolites
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
show the reaction diagram
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
show the reaction diagram
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
show the reaction diagram
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate + H2O + NAD+
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + NH3 + NADH + H+
show the reaction diagram
3,7-dideoxy-D-threo-hepto-2,6-diulosonic acid + H2O + NAD+
3-dehydroquinate + NH3 + NADH + H+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
heat precipitation and Sephadex G-25 gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21-CodonPlus (DE3)-RIL cells
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Show AA Sequence (458 entries)
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