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Information on EC 1.4.1.14 - glutamate synthase (NADH)

for references in articles please use BRENDA:EC1.4.1.14
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IUBMB Comments
A flavoprotein (FMN). The reaction takes place in the direction of L-glutamate production. The protein is composed of two domains, one hydrolysing L-glutamine to NH3 and L-glutamate (cf. EC 3.5.1.2, glutaminase), the other combining the produced NH3 with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2, glutamate dehydrogenase).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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Synonyms
nadh-gogat, glutamate synthetase, nadh-dependent glutamate synthase, nadh-glutamate synthase, nadh-gogat1, nadh-glts, nadh-gogat2, glta2, nadh-gogat i, nadh-gogat ii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 L-glutamate + NAD+ = L-glutamine + 2-oxoglutarate + NADH + H+
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L-glutamate + NAD+ + H2O = NH3 + 2-oxoglutarate + NADH + H+
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(1b)
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L-glutamate + NH3 = L-glutamine + H2O
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(1a)
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