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Information on EC 1.4.1.10 - glycine dehydrogenase for references in articles please use BRENDA:EC1.4.1.10
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EC Tree
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
dehydrogenase, glycine,
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dehydrogenase, glycine
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glycine + H2O + NAD+ = glyoxylate + NH3 + NADH + H+
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glycine:NAD+ oxidoreductase (deaminating)
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glyoxylate + NH3 + NADH
glycine + H2O + NAD+
glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
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glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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r
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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alternate pathway for formation of glycine in absence of transamination
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r
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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r
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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alternate pathway for formation of glycine in absence of transamination
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glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
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ir
glyoxylate + NH3 + NADH + H+
glycine + H2O + NAD+
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ir
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not: acetic acid, oxalic acid
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the putative glycine dehydrogenase of Mycobacterium tuberculosis catalyzes the reductive amination of glyoxylate to glycine but not the reverse reaction. It exhbits both pyruvate and glyoxylate aminating activitiesand also shows alanine dehydrogenase activity, EC 1.4.1.1, to a greater extent than glyoxylate aminating activity
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not: acetic acid, oxalic acid
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additional information
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the putative glycine dehydrogenase of Mycobacterium tuberculosis catalyzes the reductive amination of glyoxylate to glycine but not the reverse reaction. It exhbits both pyruvate and glyoxylate aminating activitiesand also shows alanine dehydrogenase activity, EC 1.4.1.1, to a greater extent than glyoxylate aminating activity
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glyoxylate + NH3 + NADH
glycine + H2O + NAD+
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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alternate pathway for formation of glycine in absence of transamination
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r
glyoxylate + NH3 + NADH
glycine + H2O + NAD+
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alternate pathway for formation of glycine in absence of transamination
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r
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NADH
Blastobacter aminovorus
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NADH
Pseudomonas methylica
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oxygen
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Hyperglycinemia, Nonketotic
Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma.
Lung Neoplasms
Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression.
Neoplasms
Epigenetic Silencing of the Putative Tumor Suppressor Gene GLDC (Glycine Dehydrogenase) in Gastric Carcinoma.
Tuberculosis
ald of Mycobacterium tuberculosis encodes both the alanine dehydrogenase and the putative glycine dehydrogenase.
Tuberculosis
Dormancy of Mycobacterium tuberculosis and latency of disease.
Tuberculosis
Glycine and alanine dehydrogenase activities are catalyzed by the same protein in Mycobacterium smegmatis: upregulation of both activities under microaerophilic adaptation.
Tuberculosis
Identification of genes required for chronic persistence of Brucella abortus in mice.
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0.0087
NADH
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anaerobic resting bacilli - RB
120
NH3
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anaerobic resting bacilli - RB
additional information
additional information
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0.22
glyoxylate
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4.3
glyoxylate
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aerobic aerated bacilli - AB
5.4
glyoxylate
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anaerobic resting bacilli - RB
5.5
glyoxylate
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pH 8.5, 22°C, recombinant enzyme
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additional information
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in vitro under anerobic conditions approximately 10fold greater than under aerobic conditions
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4-5fold increased in cells under microaerophilic conditions as compared with an aerobically grown culture
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6.4
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assay at
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22
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assay at
22
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assay at room temperature
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Blastobacter aminovorus
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H37Ra strain
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gene ald
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ATCC 607
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no activity in Arthrobacter globiformis
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no activity in Methylomonas methylovora
M8-5, M12-4
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no activity in Methylomonas methylovora M8-5 M12-4
M8-5, M12-4
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no activity in Methylophilus methanolovorus
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Pseudomonas methylica
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AM1
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AM1
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gene ald
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H37Ra strain
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additional information
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no enzyme detected in the extracellular medium
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minor fraction
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minor fraction
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major fraction
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major fraction
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malfunction
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the rs10975641 single nucleotide polymorphism in the glycine dehydrogenase gene is associated with selective serotonin reuptake inhibitors treatment outcome phenotypes, overview. Selective serotonin reuptake inhibitors are used in teatment of major depressive disorder (MDD), a common psychiatric disease
physiological function
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the enzyme plays an essential role in the utilization of alanine, but not of glycine, as a nitrogen source
physiological function
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the enzyme plays an essential role in the utilization of alanine, but not of glycine, as a nitrogen source
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additional information
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generation of ald knockout strain RVW7 from wild-type strain H37Rv
additional information
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generation of ald knockout strain RVW7 from wild-type strain H37Rv
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-17°C, 72 h, 30-50% loss of activity
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37°C, 12 d under microaerophilic conditions
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ATCC 607, partial from microaerophilic adapted cultures
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recombinant His-tagged enzyme from Escherichia coli strain ER2566 by nickel affinity chromatography, native enzyme by anion exchange and hydrophobic interaction chromatography, followed by ultrafiltration
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DNA and amino acid sequence determination and analysis, genotyping and isolation of rs10975641 single nucleotide polymorphism
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gene ald, quantitative real-time PCR expression analysis, expression in Escherichia coli strain ER2566
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transcription of ald is induced when alanine is the sole nitrogen source
transcription of ald is induced when alanine is the sole nitrogen source
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transcription of ald is induced when alanine is the sole nitrogen source
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Usha, V.; Jayaraman, R.; Toro, J.C.; Hoffner, S.E.; Das, K.S.
Glycine and alanine dehydrogenase activities are catalyzed by the same protein in Mycobacterium smegmatis: upregulation of both activities under microaerophilic adaptation
Can. J. Microbiol.
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7-13
2002
Mycolicibacterium smegmatis
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Goldman, D.S.; Wagner, M.J.
Enzyme systems in the Mycobacteria
Biochim. Biophys. Acta
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297-306
1962
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra / ATCC 25177
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Loginova, N.V.; Govorukhina, N.I.; Trotsenko, Y.A.
Enzymes of the assimilation of ammonium in bacteria with various pathways of C1-metabolism
Mikrobiologiya
51
38-42
1981
Blastobacter aminovorus, Hyphomicrobium vulgare, no activity in Arthrobacter globiformis, no activity in Methylomonas methylovora, no activity in Methylomonas methylovora M8-5 M12-4, no activity in Methylophilus methanolovorus, Pseudomonas methylica, Pseudomonas sp., Pseudomonas sp. AM1, Xanthobacter viscosus
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Wayne, L.G.; Lin, K.Y.
Glyoxylate metabolism and adaptation of Mycobacterium tuberculosis to survival under anaerobic conditions
Infect. Immun.
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1042-1049
1982
Mycobacterium tuberculosis
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Ji, Y.; Hebbring, S.; Zhu, H.; Jenkins, G.D.; Biernacka, J.; Snyder, K.; Drews, M.; Fiehn, O.; Zeng, Z.; Schaid, D.; Mrazek, D.A.; Kaddurah-Daouk, R.; Weinshilboum, R.M.
Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics
Clin. Pharmacol. Ther.
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97-104
2011
Homo sapiens
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Giffin, M.M.; Modesti, L.; Raab, R.W.; Wayne, L.G.; Sohaskey, C.D.
ald of Mycobacterium tuberculosis encodes both the alanine dehydrogenase and the putative glycine dehydrogenase
J. Bacteriol.
194
1045-1054
2012
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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1.4.1.10 glycine dehydrogenase
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