Any feedback?
Information on EC 1.3.99.6 - 3-oxo-5beta-steroid 4-dehydrogenase
for references in articles please use BRENDA:EC1.3.99.6Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
1.3.99.6 3-oxo-5beta-steroid 4-dehydrogenaseSpecify your search results
Word Map
- 1.3.99.6
-
5alpha-reductase
-
5alpha
- 11beta-hydroxysteroid
- akr1d1
-
5beta-reduced
- delta4-3-ketosteroids
- 3alpha-hsds
-
songbird
- analysis
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
5beta-reductase, delta4-3-ketosteroid-5beta-reductase, aldo-keto reductase family 1 member d1, 
more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-keto-DELTA4-steroid-5beta-reductase
-
-
-
-
3-oxo-5beta-steroid DELTA4-dehydrogenase
-
-
-
-
3-oxo-DELTA4-steroid-5beta-reductase
-
-
-
-
5beta-reductase
-
-
-
-
Aldo-keto reductase family 1 member D1
-
-
-
-
Delta(4)-3-ketosteroid 5-beta-reductase
-
-
-
-
DELTA-3-ketosteroid-5beta-reductase
-
-
-
-
DELTA4-3-ketosteroid-5beta-reductase
-
-
-
-
DELTA4-3-oxosteroid 5beta-reductase
DELTA4-5beta-DH
-
-
-
-
steroid 5beta reductase
-
-
-
-
steroid DELTA-5beta-dehydrogenase
-
-
-
-
testosterone 5beta-reductase
-
-
-
-
DELTA4-3-oxosteroid 5beta-reductase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a 3-oxo-5beta-steroid + acceptor = a 3-oxo-DELTA4-steroid + reduced acceptor
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
3-oxo-5beta-steroid:acceptor DELTA4-oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9067-97-4
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
21-hydroxy-5beta-pregnan-3,20-dione + acceptor
21-hydroxy-pregn-4-en-3,20-dione + reduced acceptor
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid + menaphthone
3,12-dioxo-4-cholen-24-oic acid + reduced menaphthone
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid + phenazine methosulfate
3,12-dioxo-4-cholen-24-oic acid + reduced phenazine methosulphate
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid methyl ester + menaphthone
3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced menaphthone
-
-
-
-
?
3,12-dioxo-5beta-cholan-24-oic acid methyl ester + phenazine methosulfate
3,12-dioxo-4-cholen-24 oic acid methyl ester + reduced phenazine methosulfate
-
-
-
-
?
3-oxo-5beta-24-cholan-oic acid + phenazine methosulfate
3-oxo-4-cholen-24-oic acid + reduced phenazine methosulfate
-
-
-
-
?
3-oxo-5beta-cholan-24-oic acid + menaphthone
3-oxo-4-cholen-24-oic acid + reduced menaphthone
-
-
-
-
?
5beta-androst-3,17-dione + acceptor
androst-1,4-dien-3,17-dione + reduced acceptor
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
5beta-androstane-3,17-dione + acceptor
androst-4-en-3,17-dione + reduced acceptor
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
5beta-pregnan-3,20-dione + menaphthone
4-pregnen-3,20-dione + reduced menaphthone
-
-
-
-
?
5beta-pregnan-3,20-dione + phenazine methosulfate
4-pregnen-3,20-dione + reduced menazine methosulfate
-
-
-
-
?
testosterone + NADH
17beta-hydroxy-5beta-androstan-3-one + NAD+
-
-
-
-
?
17beta-hydroxy-5beta-androstan-3-one + menaphthone
testosterone + reduced acceptor
-
acceptor: phenazine methosulfate
-
-
?
17beta-hydroxy-5beta-androstan-3-one + menaphthone
testosterone + reduced acceptor
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
4-pregnen-3,20-dione + NADH
5beta-pregnan-3,20-dione + NAD+
-
-
-
-
?
4-pregnen-3,20-dione + NADH
5beta-pregnan-3,20-dione + NAD+
-
i.e. progesterone
-
-
?
5beta-androstan-3,17-dione + acceptor
4-androsten-3,17-dione + reduced acceptor
-
acceptor: phenazine methosulfate
-
-
?
5beta-androstan-3,17-dione + acceptor
4-androsten-3,17-dione + reduced acceptor
-
acceptor: 1,2-naphthoquinone, 1,4-naphthoquinone, 1,4-benzoquinone, menadione or coenzyme Q10
-
-
?
5beta-androstan-3,17-dione + acceptor
4-androsten-3,17-dione + reduced acceptor
-
acceptor: nitroblue tetrazolium
-
-
?
additional information
?
-
-
no activity with: NAD+, NADP+, FMN and FAD
-
-
?
additional information
?
-
-
inducible by 3-oxo-5beta-cholan-24-oic acid
-
-
?
additional information
?
-
-
enzyme is essential in bile acids formation, analysis of bile acid contents in urine and plasma from healthy persons and 3 different patients with neonatal onset cholestatic liver disease, physiolgical role of the enzyme, overview
-
-
?
additional information
?
-
-
inducible by testosterone and progesterone
-
-
?
additional information
?
-
-
enzyme is involved in bile acid biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
-
inducible by 3-oxo-5beta-cholan-24-oic acid
-
-
?
additional information
?
-
-
enzyme is essential in bile acids formation, analysis of bile acid contents in urine and plasma from healthy persons and 3 different patients with neonatal onset cholestatic liver disease, physiolgical role of the enzyme, overview
-
-
?
additional information
?
-
-
inducible by testosterone and progesterone
-
-
?
additional information
?
-
-
enzyme is involved in bile acid biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
3-oxo-5beta-steroid 4-dehydrogenase deficiency
Characterization of disease-related 5beta-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency.
3-oxo-5beta-steroid 4-dehydrogenase deficiency
Diagnosis of the first Japanese patient with 3-oxo-delta4-steroid 5beta-reductase deficiency by use of immunoblot analysis.
3-oxo-5beta-steroid 4-dehydrogenase deficiency
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.
3-oxo-5beta-steroid 4-dehydrogenase deficiency
SRD5B1 (AKR1D1) gene analysis in delta(4)-3-oxosteroid 5beta-reductase deficiency: evidence for primary genetic defect.
3-oxo-5beta-steroid 4-dehydrogenase deficiency
SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta-steroid 5beta-reductase deficiency.
Carcinoma, Hepatocellular
Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.
Carcinoma, Hepatocellular
Proteome analysis of rat hepatomas: carcinogen-dependent tumor-associated protein variants.
Cholestasis
Bile acids modulate glucocorticoid metabolism and the hypothalamic-pituitary-adrenal axis in obstructive jaundice.
Cholestasis
Diagnosis of the first Japanese patient with 3-oxo-delta4-steroid 5beta-reductase deficiency by use of immunoblot analysis.
Cholestasis
SRD5B1 gene analysis needed for the accurate diagnosis of primary 3-oxo-Delta-steroid 5beta-reductase deficiency.
Essential Hypertension
11beta-hydroxysteroid dehydrogenase type-2 and type-1 (11beta-HSD2 and 11beta-HSD1) and 5beta-reductase activities in the pathogenia of essential hypertension.
Fatty Liver
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
Hepatitis
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.
Hyperandrogenism
Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome.
Liver Diseases
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.
Liver Failure
Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.
Non-alcoholic Fatty Liver Disease
Body fat distribution and cortisol metabolism in healthy men: enhanced 5beta-reductase and lower cortisol/cortisone metabolite ratios in men with fatty liver.
Obesity
Reduced adipose glucocorticoid reactivation and increased hepatic glucocorticoid clearance as an early adaptation to high-fat feeding in Wistar rats.
Polycystic Ovary Syndrome
Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
8.5 - 10.5
-
pH 8.5: about 40% of maximal activity, pH 10.5: about 20% of maximal activity
9
-
above pH 9.0, the rate of DELTA4-5beta-dehydrogenase reaction increases with pH to the limit where accurate measurement can be made, pH 9.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
31 - 43
-
31°C: about 70% of maximal activity, 43°C: about 60% of maximal activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene SRD5B1, enzyme AKR1D1, healthy persons and 3 different patients with neonatal onset cholestatic liver disease and normal gamma-glutamyl transpeptidase activity
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
from patients late in pregnancy, before term labour, during term labour and within the first 24 h postpartum
brenda
-
relative expression decreases significantly in association with labour by about 10fold
brenda
-
mRNA is expressed in hepatocyte-like cells of rats treated with copper depletion regimen but not in the normal pancreas of rat fed a normal diet
brenda
-
most highly expressed, relative expression decreases significantly in association with labour by about 2fold
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). R4SCT3_BRARP
390
0
44031
TrEMBL
other Location (Reliability: 2)
A0A2P6PLJ0_ROSCH
387
0
43821
TrEMBL
other Location (Reliability: 3)
A0A0M4C590_VITVI
391
0
44647
TrEMBL
other Location (Reliability: 3)
K9Y750_RAPSA
390
0
44311
TrEMBL
other Location (Reliability: 2)
K9Y857_NASOF
388
0
43796
TrEMBL
other Location (Reliability: 2)
K9Y6Z6_9LAMI
389
0
43705
TrEMBL
other Location (Reliability: 4)
A0A0M3Q1Q2_ARASO
390
0
44014
TrEMBL
other Location (Reliability: 2)
A0A0K1JRZ0_RICCO
390
0
44222
TrEMBL
other Location (Reliability: 4)
H9DP75_BRAOG
382
0
43034
TrEMBL
other Location (Reliability: 2)
V9QFI1_9LAMI
354
0
40143
TrEMBL
other Location (Reliability: 3)
M1G4Y5_9SOLA
388
0
43740
TrEMBL
other Location (Reliability: 2)
S5ZYI5_CARPT
388
0
44108
TrEMBL
other Location (Reliability: 2)
A0A0K1JRG5_ALBBR
391
0
44148
TrEMBL
Mitochondrion (Reliability: 3)
A0A2P6PLK5_ROSCH
387
0
43701
TrEMBL
other Location (Reliability: 3)
A0A2G9HDB4_9LAMI
389
0
44139
TrEMBL
other Location (Reliability: 3)
A0A0M5I9A7_FRAVE
390
0
43751
TrEMBL
other Location (Reliability: 4)
R9UQZ3_LEPSV
392
0
44463
TrEMBL
other Location (Reliability: 2)
A0A2G9HCM6_9LAMI
389
0
44113
TrEMBL
other Location (Reliability: 4)
V9QFK0_9LAMI
354
0
40115
TrEMBL
other Location (Reliability: 3)
A0A2G9HCN6_9LAMI
389
0
44137
TrEMBL
other Location (Reliability: 3)
A0A2G9FZQ9_9LAMI
389
0
44026
TrEMBL
other Location (Reliability: 3)
V9LVN0_ROSOF
389
0
44103
TrEMBL
other Location (Reliability: 3)
W6CRF5_9ROSI
390
0
43513
TrEMBL
other Location (Reliability: 2)
S5YZ35_BARVU
388
0
43968
TrEMBL
other Location (Reliability: 2)
A0A024DAK6_STEME
390
0
43662
TrEMBL
other Location (Reliability: 2)
A0A024DA00_THLAR
389
0
43873
TrEMBL
other Location (Reliability: 2)
A0A2G9G080_9LAMI
389
0
44038
TrEMBL
other Location (Reliability: 3)
C4PL35_HUMAN
169
0
18887
TrEMBL
other Location (Reliability: 2)
I6VEY6_9BRAS
389
0
43750
TrEMBL
other Location (Reliability: 3)
A0A0M4BW04_ALLUR
397
0
44348
TrEMBL
Mitochondrion (Reliability: 3)
R9UTP5_BRAJU
388
0
43614
TrEMBL
other Location (Reliability: 2)
E3TEK6_ICTPU
326
0
37288
TrEMBL
other Location (Reliability: 1)
W6CNX0_SINAR
390
0
44136
TrEMBL
other Location (Reliability: 2)
W6CPY4_CAPBU
386
0
43254
TrEMBL
other Location (Reliability: 2)
W6CYX5_9BRAS
388
0
43929
TrEMBL
other Location (Reliability: 2)
A0A0B5CYJ8_CUCPE
393
0
44989
TrEMBL
other Location (Reliability: 3)
A0A0K1JRW5_9ROSI
389
0
43663
TrEMBL
other Location (Reliability: 3)
A0A0M4LA48_9BRAS
388
0
43475
TrEMBL
other Location (Reliability: 2)
A0A0M4BTX3_CONMJ
398
0
44134
TrEMBL
Mitochondrion (Reliability: 5)
A0A2Z0T9C4_CAMSA
388
0
44094
TrEMBL
other Location (Reliability: 2)
A0A024D9Z7_COCOF
389
0
43648
TrEMBL
other Location (Reliability: 2)
C4PL37_HUMAN
16
0
1608
TrEMBL
other Location (Reliability: 1)
A0A060A9K5_9BRAS
388
0
43987
TrEMBL
other Location (Reliability: 2)
K7TNM5_BUPFA
388
0
44234
TrEMBL
other Location (Reliability: 4)
A0A0M5KK18_9BRAS
392
0
44134
TrEMBL
other Location (Reliability: 2)
A0A2Z0TJR5_BRACM
390
0
44285
TrEMBL
other Location (Reliability: 2)
A0A0M5IM54_CAMMC
388
0
43963
TrEMBL
other Location (Reliability: 2)
A0A2Z0TH17_EUTJA
390
0
44434
TrEMBL
other Location (Reliability: 2)
R9WQI3_MATTR
387
0
43652
TrEMBL
other Location (Reliability: 2)
R9WM03_9BRAS
384
0
44129
TrEMBL
other Location (Reliability: 2)
K7TAY3_PASIN
389
0
44348
TrEMBL
other Location (Reliability: 5)
A0A024DBM0_9BRAS
387
0
43556
TrEMBL
other Location (Reliability: 3)
A0A2G9HIH6_9LAMI
268
0
30665
TrEMBL
other Location (Reliability: 4)
S5YT80_9LAMI
389
0
43960
TrEMBL
other Location (Reliability: 4)
A0A024D9W4_IBEAM
389
0
43997
TrEMBL
other Location (Reliability: 2)
R9QRF6_THYVU
389
0
43849
TrEMBL
other Location (Reliability: 4)
S5ZIA3_9BRAS
386
0
44262
TrEMBL
other Location (Reliability: 2)
A0A2G9GA31_9LAMI
387
0
44114
TrEMBL
other Location (Reliability: 3)
R9QR37_SPIOL
398
0
45382
TrEMBL
other Location (Reliability: 4)
K9Y653_AETGR
388
0
43983
TrEMBL
other Location (Reliability: 2)
A0A024DAY5_ISATI
390
0
44124
TrEMBL
other Location (Reliability: 2)
C4PL36_HUMAN
179
0
19901
TrEMBL
other Location (Reliability: 4)
V9QFI8_9LAMI
354
0
40059
TrEMBL
other Location (Reliability: 3)
A0A0K1JRH9_POPTR
390
0
43710
TrEMBL
Mitochondrion (Reliability: 4)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
L106F
-
naturally occurring mutation of C385T in patient RM, homozygous, patient shows giant cell hepatitis and prominent extramedullary haemopoiesis
P198L
-
naturally occurring mutation of C662T in patient MS, homozygous, patient shows giant cell hepatitis
additional information
-
in patient BH naturally occurs a frame shift due to a base deletion, 511delT, resulting in a premature stop codon in exon 5, patient shows giant cell hepatitis and prominent extramedullary haemopoiesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
OXIDATION STABILITY
ORGANISM
UNIPROT
LITERATURE
oxygen-sensitive
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, in neutral buffer, 20% glycerol, about 50% loss of activity after 1 month
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene SRD5B1, DNA sequence determination and analysis from healthy persons and 3 different patients with neonatal onset cholestatic liver disease and normal gamma-glutamyl transpeptidase activity, parents and siblings
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
analysis
-
determination of the concentration of chenodeoxycholic acid by an enzyme kit consisting of 3alpha-hydroxysteroid dehydrogenase, 3-keto-5beta-steroid-DELTA4-dehydrogenase, NAD+, nitroblue tetrazolium, diaphorase and some other reagents
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Stokes, N.A.; Hylemon, P.B.
Characterization of DELTA4-3-ketosteroid-5beta-reductase and 3beta-hydroxysteroid dehydrogenase in cell extracts of Clostridium innocuum
Biochim. Biophys. Acta
836
255-261
1985
[Clostridium] innocuum, Clostridium paraputrificum
brenda
Gao, X.; Liu, J.; Li, G.
Purification and properties of 3alpha-hydroxysteroid dehydrogenase and 3-keto-5beta-steroid-DELTA4-dehydrogenase
Ann. N. Y. Acad. Sci.
864
383-392
1998
Pseudomonas sp.
brenda
Aries, V.C.; Goddard, P.; Hill, M.J.
Degradation of steroids by intestinal bacteria. III. 3-Oxo-5beta-steroid DELTA1-dehydrogenase and 3-oxo-5beta-steroid DELTA4-dehydrogenase
Biochim. Biophys. Acta
248
482-488
1971
Clostridium paraputrificum
-
brenda
Davidson, S.J.; Talalay, P.
Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase
J. Biol. Chem.
241
906-915
1966
Comamonas testosteroni
brenda
Zhu, Y.; Fillienwarth, M.J.; Crabb, D.; Lumeng, L.; Lin, R.C.
Identification of the 37-kd rat liver protein that forms an acetaldehyde adduct in vivo as DELTA4-3-ketosteroid 5beta-reductase
Hepatology
23
115-122
1996
Rattus norvegicus
brenda
Ando, Y.; Ide, H.; Kosai, S.; Kamimura, R.; Maeda, Y.; Higashi, S.; Setoguchi, T.
Expression of cholesterol 7alpha-hydroxylase and DELTA4-3-ketosteroid 5beta-reductase genes in rat pancreatic hepatocyte-like cells
J. Lipid Res.
40
1793-1798
1999
Rattus norvegicus
brenda
Lemonde, H.A.; Custard, E.J.; Bouquet, J.; Duran, M.; Overmars, H.; Scambler, P.J.; Clayton, P.T.
Mutations in SRD5B1 (AKR1D1), the gene encoding DELTA4-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy
Gut
52
1494-1499
2003
Homo sapiens
brenda
Sheenan, P.M.; Rice, G.E.; Moses, E.K.; Brennecke, S.P.
5beta-Dihydroprogesterone and steroid 5beta-reductase decrease in association with human parturition at term
Mol. Hum. Reprod.
11
495-501
2005
Homo sapiens
brenda
Select items on the left to see more content.
EXTERNAL LINKS (specific for EC-Number 1.3.99.6)
html completed
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
About BRENDA
Social media
Help
Survey
Download
Contribution
Legal
Curated at
Member of
