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Information on EC 1.3.99.38 - menaquinone-9 beta-reductase and Organism(s) Mycolicibacterium smegmatis and UniProt Accession A0QRI8

for references in articles please use BRENDA:EC1.3.99.38
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IUBMB Comments
The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
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This record set is specific for:
Mycolicibacterium smegmatis
UNIPROT: A0QRI8
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The taxonomic range for the selected organisms is: Mycolicibacterium smegmatis
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
rv0561c, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
menaquinone-9 oxidoreductase (beta-dihydromenaquinone-9-forming)
The enzyme from the bacterium Mycobacterium tuberculosis reduces the beta-isoprene unit of menaquinone-9, forming the predominant form of menaquinone found in mycobacteria. Contains FAD.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
menaquinone-9 + reduced acceptor
beta-dihydromenaquinone-9 + acceptor
show the reaction diagram
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beta dihaydromenaquinone-9 i.e. menaquinone with 9 isoprene units in the side chain, with the one in the second (beta) position saturated
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?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pharmacology
menaquinone synthesis may be a drug target in Mycobacteria
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Upadhyay, A.; Fontes, F.L.; Gonzalez-Juarrero, M.; McNeil, M.R.; Crans, D.C.; Jackson, M.; Crick, D.C.
Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase, MenJ
ACS Cent. Sci.
1
292-302
2015
Mycobacterium tuberculosis (P9WNY9), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNY9), Mycolicibacterium smegmatis (A0QRI8), Mycolicibacterium smegmatis ATCC 700084 (A0QRI8)
Manually annotated by BRENDA team