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15-cis-phytoene + 3 acceptor
all-trans-neurosporene + 3 reduced acceptor
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
15-cis-phytoene + 4 acceptor
all-trans-lycopene + reduced 4 acceptor
-
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
15-cis-phytoene + FAD
all-trans-phytofluene + FADH2
-
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
all-trans-neurosporene + FAD
all-trans-lycopene + FADH2
-
-
-
-
?
all-trans-phytofluene + 3 acceptor
all-trans-lycopene + 3 reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
all-trans-phytofluene + FAD
all-trans-zeta-carotene + FADH2
-
-
-
-
?
all-trans-zeta-carotene + 2 acceptor
all-trans-lycopene + 2 reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
all-trans-zeta-carotene + FAD
all-trans-neurosporene + FADH2
-
-
-
-
?
additional information
?
-
15-cis-phytoene + 3 acceptor

all-trans-neurosporene + 3 reduced acceptor
-
-
-
-
?
15-cis-phytoene + 3 acceptor
all-trans-neurosporene + 3 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
-
-
?
15-cis-phytoene + 3 acceptor
all-trans-neurosporene + 3 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg) and 26:74 after complementation of CrtI in pPEU(DH5a/pACCrtEBEU/pPEUCrtIRg). The affinity for neurosporene conversion is poorer than for phytoene conversion. This explains the formation of two desaturation products
-
-
?
15-cis-phytoene + 4 acceptor

all-trans-lycopene + 4 reduced acceptor
overall reaction. all-trans-Lycopene is the principal desaturase product constituting 60% of the total reaction products. The desaturase intermediates all-trans-phytofluene and all-trans-zeta-carotene are also detected and constitute 27 and 12% of the total desaturase products formed
-
-
?
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
-
-
-
-
?
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
-
-
?
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg) and 26:74 after complementation of CrtI in pPEU(DH5a/pACCrtEBEU/pPEUCrtIRg). The affinity for neurosporene conversion is poorer than for phytoene conversion. This explains the formation of two desaturation products
-
-
?
15-cis-phytoene + acceptor

all-trans-phytofluene + reduced acceptor
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
-
?
all-trans-neurosporene + acceptor

all-trans-lycopene + reduced acceptor
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
-
?
all-trans-phytofluene + acceptor

all-trans-zeta-carotene + reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
-
?
all-trans-zeta-carotene + acceptor

all-trans-neurosporene + reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
-
?
additional information

?
-
-
enzyme catalyzes lycopene formation in in four steps from phytoeneto phytofluene to zeta-carotene to neurosporene to lycopene, with 100% efficiency of formation of the end product
-
-
?
additional information
?
-
-
enzyme catalyzes lycopene formation in in four steps from phytoeneto phytofluene to zeta-carotene to neurosporene to lycopene, with 100% efficiency of formation of the end product
-
-
?
additional information
?
-
at higher concentrations, phytoene is the preferred substrate for CrtI, and neurosporene is produced as the major desaturation product, EC 1.3.99.28. At lower phytoene concentrations, neurosporene can be further desaturated by CrtI to produce lycopene
-
-
?
additional information
?
-
catalyzes both enzymatic conversion of phytoene to lycopene (fourth step product) and 3,4-didehydrolycopene (fifth step product), reactions of EC 1.3.99.30 and EC 1.3.99.31, respectively
-
-
?
additional information
?
-
catalyzes both enzymatic conversion of phytoene to lycopene (fourth step product) and 3,4-didehydrolycopene (fifth step product), reactions of EC 1.3.99.30 and EC 1.3.99.31, respectively
-
-
?
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15-cis-phytoene + 3 acceptor
all-trans-neurosporene + 3 reduced acceptor
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
15-cis-phytoene + 4 acceptor
all-trans-lycopene + reduced 4 acceptor
-
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
15-cis-phytoene + FAD
all-trans-phytofluene + FADH2
-
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
all-trans-neurosporene + FAD
all-trans-lycopene + FADH2
-
-
-
-
?
all-trans-phytofluene + 3 acceptor
all-trans-lycopene + 3 reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
all-trans-phytofluene + FAD
all-trans-zeta-carotene + FADH2
-
-
-
-
?
all-trans-zeta-carotene + 2 acceptor
all-trans-lycopene + 2 reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
all-trans-zeta-carotene + FAD
all-trans-neurosporene + FADH2
-
-
-
-
?
additional information
?
-
at higher concentrations, phytoene is the preferred substrate for CrtI, and neurosporene is produced as the major desaturation product, EC 1.3.99.28. At lower phytoene concentrations, neurosporene can be further desaturated by CrtI to produce lycopene
-
-
?
15-cis-phytoene + 3 acceptor

all-trans-neurosporene + 3 reduced acceptor
-
-
-
-
?
15-cis-phytoene + 3 acceptor
all-trans-neurosporene + 3 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
-
-
?
15-cis-phytoene + 4 acceptor

all-trans-lycopene + 4 reduced acceptor
overall reaction. all-trans-Lycopene is the principal desaturase product constituting 60% of the total reaction products. The desaturase intermediates all-trans-phytofluene and all-trans-zeta-carotene are also detected and constitute 27 and 12% of the total desaturase products formed
-
-
?
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
-
-
-
-
?
15-cis-phytoene + 4 acceptor
all-trans-lycopene + 4 reduced acceptor
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
-
-
?
15-cis-phytoene + acceptor

all-trans-phytofluene + reduced acceptor
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
-
?
15-cis-phytoene + acceptor
all-trans-phytofluene + reduced acceptor
-
-
-
-
?
all-trans-neurosporene + acceptor

all-trans-lycopene + reduced acceptor
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
-
?
all-trans-neurosporene + acceptor
all-trans-lycopene + reduced acceptor
-
-
-
-
?
all-trans-phytofluene + acceptor

all-trans-zeta-carotene + reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
-
?
all-trans-phytofluene + acceptor
all-trans-zeta-carotene + reduced acceptor
-
-
-
-
?
all-trans-zeta-carotene + acceptor

all-trans-neurosporene + reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
-
?
all-trans-zeta-carotene + acceptor
all-trans-neurosporene + reduced acceptor
-
-
-
-
?
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evolution
-
CRTI-type phytoene desaturases prevailing in bacteria and fungi can form lycopene directly from phytoene while plants employ two distinct desaturases and two cis-tans isomerases for the same purpose
malfunction
-
a mutant of Rubrivivax gelatinosus lacking the crtI gene produces only phytoene, indicating that this organism has no other phytoene desaturases. When the crtI deletion mutant is complemented by the three-step phytoene desaturase of Rhodobacter capsulatus, spirilloxanthin and its precursors are not synthesized, although spheroidene and OH-spheroidene are accumulated
metabolism

-
CrtI produces lycopene exclusively as an end product, not as an intermediate in spirilloxanthin, carotenoid biosynthesis pathway in Rhodospirillum rubrum, overview
metabolism
the enzyme is involved catalyzing several steps in the beta-carotene biosynthetic pathway via phytoene, zeta-carotene, and lycopene, overview
metabolism
-
CrtI produces lycopene exclusively as an end product, not as an intermediate in spirilloxanthin, carotenoid biosynthesis pathway in Rhodospirillum rubrum, overview
-
physiological function

the enzyme is involved in carotenoid biosynthesis
physiological function
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene
physiological function
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
physiological function
-
CRTI is a membrane-peripheral oxidoreductase which utilizes FAD as the sole redox-active cofactor. Oxygen, replaceable by quinones in its absence, is needed as the terminal electron acceptor. FAD, besides its catalytic role also displays a structural function by enabling the formation of enzymatically active CRTI membrane associates. Under anaerobic conditions the enzyme can act as a carotene cis-trans isomerase. In silico-docking experiments yielded information on substrate binding sites, potential catalytic residues and is in favor of single half-site recognition of the symmetrical C40 hydrocarbon substrate
physiological function
-
in vivo, lycopene is incorporated into the light-harvesting complex 1 as efficiently as the methoxylated carotenoids spirilloxanthin (in the wild-type) and 3,4,3',4'-tetrahydrospirilloxanthin (in a crtD mutant), both under semiaerobic, chemoheterotrophic, and photosynthetic, anaerobic conditions, quantitative growth experiments, overview
physiological function
the expression product of crtI is essential for phytoene conversion to lycopene and 3,4-didehydrolycopene
physiological function
-
the enzyme simultaneously catalyzes a three- and four-step desaturation of phytoene producing both neurosporene and lycopene. These carotenes are intermediates for the synthesis of spheroidene and spirilloxanthin, respectively
-
physiological function
-
in vivo, lycopene is incorporated into the light-harvesting complex 1 as efficiently as the methoxylated carotenoids spirilloxanthin (in the wild-type) and 3,4,3',4'-tetrahydrospirilloxanthin (in a crtD mutant), both under semiaerobic, chemoheterotrophic, and photosynthetic, anaerobic conditions, quantitative growth experiments, overview
-
physiological function
-
the expression product of crtI is essential for phytoene conversion to lycopene and 3,4-didehydrolycopene
-
additional information

Rhodobacter azotoformans contains a carotenogenesis gene cluster with an unusual organization and a phytoene desaturase catalyzing both three- and four-step desaturations. CrtI from Rhodobacter azotoformans CGMCC 6086 can produce three-step desaturated neurosporene and four-step desaturated lycopene as major products, see also EC 1.3.99.28, together with small amounts of five-step desaturated 3,4-didehydrolycopene, EC 1.3.99.30
additional information
-
Rhodobacter azotoformans contains a carotenogenesis gene cluster with an unusual organization and a phytoene desaturase catalyzing both three- and four-step desaturations. CrtI from Rhodobacter azotoformans CGMCC 6086 can produce three-step desaturated neurosporene and four-step desaturated lycopene as major products, see also EC 1.3.99.28, together with small amounts of five-step desaturated 3,4-didehydrolycopene, EC 1.3.99.30
-
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L153P/L278P
-
increased formation of neurosporene compared to wild-type enzyme. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg), the ratio of the mutant enzyme is 12:88
L208F
-
increased formation of lycopene compared to wild-type enzyme. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 26:74 after complementation of CrtI in pPEU(DH5a/pACCrtEBEU/pPEUCrtIRg), the ratio of the mutant enzyme is 89:11
L208P
-
increased formation of neurosporene compared to wild-type enzyme. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg), the ratio of the mutant enzyme is 3:97
T256M/D355GL424P
-
increased formation of neurosporene compared to wild-type enzyme. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg), the ratio of the mutant enzyme is 0:100
Y44C/D53G/P134L/V395A
-
increased formation of neurosporene compared to wild-type enzyme. The ratio of lycopene to neurosporene of the wild-type enzyme under assay conditions is 88:12 after complementation of CrtI in pUC8(DH5a/pACCrtEBEU/pUCCrtIRg), the ratio of the mutant enzyme is 3:97
additional information

enzyme modification by site-directed mutagenesis, overview
additional information
-
construction of the lycopene-producing mutant, SLYC18, and analysis of mutant strains SLYC18 and ST4, mutated in crtC and crt D or crtC genes, respectively, and quantitative analysis of their carotenoid spectrum as well as light harvesting LH1 complex, functional complementation, overview. The crtC crtD deletion mutant produces lycopene exclusively as a final product
additional information
-
construction of the lycopene-producing mutant, SLYC18, and analysis of mutant strains SLYC18 and ST4, mutated in crtC and crt D or crtC genes, respectively, and quantitative analysis of their carotenoid spectrum as well as light harvesting LH1 complex, functional complementation, overview. The crtC crtD deletion mutant produces lycopene exclusively as a final product
-
additional information
-
two different mutation libraries for the crtI gene are constructed to screen for modified enzymes which synthesize almost exclusively either neurosporene or lycopene. The resulting mutants carry between one and four amino acid exchanges and at least one of them affects the secondary protein structure by shortening or extending one of the helices. A prominent amino acid which is exchanged in the neurosporene or lycopene-forming desaturase is leucine 208. Enzyme kinetic studies are carried out with the L208 modified desaturase and the specificities for phytoene and neurosporene as substrates determined. Higher and lower values correlate well with the higher or lower potential for the synthesis of lycopene from neurosporene. TopPred analysis of the mutations of L208 indicate that the location is in a highly hydrophobic membrane-integrated region which is a good candidate for the substrate-binding site of the desaturase
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expression in Escherichia coli
expression in Escherichia coli. Synthesis of the enzyme by different vectors with high and lower copy numbers or strong and weak promoters results in variable ratios of lycopene and neurosporene formation. The highest amount of enzyme is produced with pUC vectors with high copy number and a strong promoter. This transformant synthesizes the highest lycopene amount. The lowest enzyme concentrations is found with pPEU carrying a weak promoter. In this transformant lycopene formation is minor. With increased enzyme concentration, a proportion of lycopene higher than in Rubrivivax gelatinosus cells can be obtained
-
gene crtI, cloning of cluster crtCDEF
-
gene crtI, cloning of the crt gene cluster crtCDEF, expression of His-tagged enzyme in Escherichia coli strain BL21(DE3)
gene crtI, recombinant coexpression of genes crtE, crtB, and crtI from Erwinia uredovora and of crtL from Ficus carica in Pichia pastoris X-33 strains for large-scale biosynthesis of carotenoids, subcloning of crtI in Escherichhia coli strain TOP10
gene crtI, recombinant expression of His6-tagged enzyme in Escherichia coli
-
overexpression in Saccharomyces cerevisiae. Yeast cells expressing CrtI, CrtYB, and CrtS from Xanthophyllomyces dendrorhous accumulate beta-carotene but not astaxanthin
expression in Escherichia coli

-
expression in Escherichia coli
expression in Escherichia coli
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Misawa, N.; Nakagawa, M.; Kobayashi, K.; Yamano, S.; Izawa, Y.; Nakamura, K.; Harashima, K.
Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli
J. Bacteriol.
172
6704-6712
1990
Pantoea ananatis (P21685)
brenda
Stickforth, P.; Sandmann, G.
Kinetic variations determine the product pattern of phytoene desaturase from Rubrivivax gelatinosus
Arch. Biochem. Biophys.
461
235-241
2007
Rubrivivax gelatinosus
brenda
Stickforth, P.; Sandmann, G.
Structural and kinetics properties of a mutated phytoene desaturase from Rubrivivax gelatinosus with modified product specificity
Arch. Biochem. Biophys.
505
118-122
2011
Rubrivivax gelatinosus
brenda
Fraser, P.D.; Misawa, N.; Linden, H.; Yamano, S.; Kobayashi, K.; Sandmann, G.
Expression in Escherichia coli, purification, and reactivation of the recombinant Erwinia uredovora phytoene desaturase
J. Biol. Chem.
267
19891-19895
1992
Pantoea ananatis (P21685)
brenda
Harada, J.; Nagashima, K.V.; Takaichi, S.; Misawa, N.; Matsuura, K.; Shimada, K.
Phytoene desaturase, CrtI, of the purple photosynthetic bacterium, Rubrivivax gelatinosus, produces both neurosporene and lycopene
Plant Cell Physiol.
42
1112-1118
2001
Rubrivivax gelatinosus
brenda
Wang, G.S.; Grammel, H.; Abou-Aisha, K.; Saegesser, R.; Ghosh, R.
High-level production of the industrial product lycopene by the photosynthetic bacterium Rhodospirillum rubrum
Appl. Environ. Microbiol.
78
7205-7215
2012
Rhodospirillum rubrum, Rhodospirillum rubrum S1
brenda
Araya-Garay, J.M.; Feijoo-Siota, L.; Rosa-dos-Santos, F.; Veiga-Crespo, P.; Villa, T.G.
Construction of new Pichia pastoris X-33 strains for production of lycopene and beta-carotene
Appl. Microbiol. Biotechnol.
93
2483-2492
2012
Pantoea ananatis (P21685)
brenda
Zhang, J.; Lu, L.; Yin, L.; Xie, S.; Xiao, M.
Carotenogenesis gene cluster and phytoene desaturase catalyzing both three- and four-step desaturations from Rhodobacter azotoformans
FEMS Microbiol. Lett.
333
138-145
2012
Luteovulum azotoformans (G3FHJ1), Luteovulum azotoformans CGMCC 6086 (G3FHJ1)
brenda
Schaub, P.; Yu, Q.; Gemmecker, S.; Poussin-Courmontagne, P.; Mailliot, J.; McEwen, A.G.; Ghisla, S.; Al-Babili, S.; Cavarelli, J.; Beyer, P.
On the structure and function of the phytoene desaturase CRTI from Pantoea ananatis, a membrane-peripheral and FAD-dependent oxidase/isomerase
PLoS ONE
7
e39550
2012
Pantoea ananatis
brenda
Chi, S.C.; Mothersole, D.J.; Dilbeck, P.; Niedzwiedzki, D.M.; Zhang, H.; Qian, P.; Vasilev, C.; Grayson, K.J.; Jackson, P.J.; Martin, E.C.; Li, Y.; Holten, D.; Neil Hunter, C.
Assembly of functional photosystem complexes in Rhodobacter sphaeroides incorporating carotenoids from the spirilloxanthin pathway
Biochim. Biophys. Acta
1847
189-201
2015
Pantoea agglomerans
brenda
Li, C.; Zhang, N.; Song, J.; Wei, N.; Li, B.; Zou, H.; Han, X.
A single desaturase gene from red yeast Sporidiobolus pararoseus is responsible for both four- and five-step dehydrogenation of phytoene
Gene
590
169-176
2016
Sporidiobolus pararoseus (A0A0K0QVD9), Sporidiobolus pararoseus CGMCC 2.5280 (A0A0K0QVD9)
brenda
Bolshakov, M.; Ashikhmin, A.; Makhneva, Z.; Moskalenko, A.
Effect of illumination intensity and inhibition of carotenoid biosynthesis on assembly of peripheral light-harvesting complexes in purple sulfur bacteria Allochromatium vinosum ATCC 17899
Microbiology
85
420-429
2016
Allochromatium vinosum, Allochromatium vinosum ATCC 17899
-
brenda
Ukibe, K.; Hashida, K.; Yoshida, N.; Takagi, H.
Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance
Appl. Environ. Microbiol.
75
7205-7211
2009
Phaffia rhodozyma (O13506), Phaffia rhodozyma ATCC 24202 (O13506)
brenda