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Information on EC 1.3.99.17 - quinoline 2-oxidoreductase
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1.3.99.17 quinoline 2-oxidoreductaseIUBMB Comments
Quinolin-2-ol, quinolin-7-ol, quinolin-8-ol, 3-, 4- and 8-methylquinolines and 8-chloroquinoline are substrates. Iodonitrotetrazolium chloride can act as an electron acceptor.
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Word Map
- 1.3.99.17
- molybdenum
- putida
- molybdopterin
- cytosine
- hydroxylases
- epr
-
1-oxidoreductase
-
molybdenum-containing
- isoquinoline
- xanthine
-
acid-labile
-
comamonas
-
quinaldine
- diminuta
- fe
-
4-oxidase
- dithionite
-
spec
- testosteroni
- rhodococcus
-
procaryotic
-
c4-substituted
-
half-site
- quinoxaline
- oxos
- synthesis
The enzyme appears in viruses and cellular organisms
Synonyms
quinoline 2-oxidoreductase, quinoline oxidoreductase, quinor, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Dehydrogenase, quinoline 2-
-
-
-
-
Qor
quinoline 2-oxidoreductase
Quinoline oxidoreductase
-
-
-
-
QuinOr
-
-
-
-
Qor
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
quinoline + acceptor + H2O = quinolin-2(1H)-one + reduced acceptor
-
-
-
-
quinoline + acceptor + H2O = quinolin-2(1H)-one + reduced acceptor
putative substrate binding mode
-
quinoline + acceptor + H2O = quinolin-2(1H)-one + reduced acceptor
putative substrate binding mode
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
-
-
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SYSTEMATIC NAME
IUBMB Comments
quinoline:acceptor 2-oxidoreductase (hydroxylating)
Quinolin-2-ol, quinolin-7-ol, quinolin-8-ol, 3-, 4- and 8-methylquinolines and 8-chloroquinoline are substrates. Iodonitrotetrazolium chloride can act as an electron acceptor.
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CAS REGISTRY NUMBER
COMMENTARY
132264-32-5
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
(3-Methyl)-quinoline + acceptor + H2O
?
-
first step of 3-methylquinoline degradation
-
-
?
isoquinoline + p-iodonitrotetrazolium violet
?
-
75% of the activity with quinoline
-
-
?
pyrimidine + p-iodonitro-tetrazolium violet + H2O
pyrimidine-4-one + reduced p-iodomitro-tetrazolium violet
pyrimidine-4-one + p-iodonitro-tetrazolium violet + H2O
? + reduced p-iodonitro-tetrazolium violet
quinoline + acceptor + H2O
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
-
-
-
?
Quinoline + acceptor + H2O
?
-
first step of quinoline degradation
-
-
?
quinoline + H2O + iodonitrotetrazolium chloride
isoquinolin-1-one + reduced iodonitrotetrazolium chloride
quinoline + iodonitrotetrazolium chloride + H2O
isoquinoline-1-one + reduced iodonitrotetrazolium chloride
-
-
-
?
quinoline + p-iodonitro-tetrazolium violet + H2O
isoquinoline-1-one + reduced p-iodonitro-tetrazolium violet
quinoxaline + acceptor + H2O
2-oxoquinoxaline + reduced acceptor
-
-
-
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
acceptor: p-iodonitrotetrazolium violet
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
61% of the activity with quinoline
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
22% of the activity with quinoline
-
-
?
(3-methyl)-quinoline + acceptor
(3-methyl-)2-oxo-1,2-dihydroquinoline + reduced p-iodonitrotetrazolium violet
-
20% of the activity with quinoline
-
-
?
4-chloroquinoline + p-iodonitrotetrazolium violet
?
-
5% of the activity with quinoline
-
-
?
4-chloroquinoline + p-iodonitrotetrazolium violet
?
-
8% of the activity with quinoline
-
-
?
4-methylquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
4-methylquinoline + acceptor
?
-
12% of the activity with quinoline
-
-
?
4-methylquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
4-methylquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
5-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
5-hydroxyquinoline + acceptor
?
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
5-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
5-hydroxyquinoline + acceptor
?
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
6-hydroxyquinoline + acceptor
?
-
58% of the activity with quinoline
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
6-hydroxyquinoline + acceptor
?
-
25% of the activity with quinoline
-
-
?
6-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
6-hydroxyquinoline + acceptor
?
-
56% of the activity with quinoline
-
-
?
7-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
7-hydroxyquinoline + acceptor
?
-
acceptor: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
7-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
7-hydroxyquinoline + acceptor
?
-
27% of the activity with quinoline
-
-
?
8-chloroquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
8-chloroquinoline + acceptor
?
-
55% of the activity with quinoline
-
-
?
8-chloroquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
8-chloroquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
8-chloroquinoline + acceptor
?
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
8-chloroquinoline + acceptor
?
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acceptor: p-iodonitrotetrazolium violet
-
-
?
8-chloroquinoline + acceptor
?
-
29% of the activity with quinoline
-
-
?
8-hydroxyquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
8-hydroxyquinoline + acceptor
?
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride], 2,6-dichlorophenolindophenol, phenazine-methosulfate, methylene blue
-
-
?
8-methylquinoline + acceptor
?
-
54% of the activity with quinoline
-
-
?
8-methylquinoline + acceptor
?
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
8-methylquinoline + acceptor
?
-
acceptor: p-iodonitrotetrazolium violet
-
-
?
pyrimidine + p-iodonitro-tetrazolium violet + H2O
pyrimidine-4-one + reduced p-iodomitro-tetrazolium violet
-
-
-
-
?
pyrimidine + p-iodonitro-tetrazolium violet + H2O
pyrimidine-4-one + reduced p-iodomitro-tetrazolium violet
-
-
-
-
?
pyrimidine-4-one + p-iodonitro-tetrazolium violet + H2O
? + reduced p-iodonitro-tetrazolium violet
-
-
-
-
?
pyrimidine-4-one + p-iodonitro-tetrazolium violet + H2O
? + reduced p-iodonitro-tetrazolium violet
-
-
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: p-iodonitrotetrazolium violet
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
-
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: ferricyanide, 1,4-benzoquinone, 1,2-naphthoquinone, thionine, nitroblue tetrazolium, medola's blue
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride]
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: p-iodonitrotetrazolium violet
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: p-iodonitrotetrazolium violet
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptors: 3,3'-(3,3'-dimethoxy-4,4'-bi-phenylene)-bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride]
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
2,6-dichlorophenolindophenol, phenazine methosulfate, methylene blue
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
acceptor: 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
-
?
quinoline + acceptor
2-oxo-1,2-dihydroquinoline + reduced acceptor
-
-
-
-
?
quinoline + H2O + iodonitrotetrazolium chloride
isoquinolin-1-one + reduced iodonitrotetrazolium chloride
-
-
-
-
?
quinoline + H2O + iodonitrotetrazolium chloride
isoquinolin-1-one + reduced iodonitrotetrazolium chloride
-
-
-
-
?
quinoline + p-iodonitro-tetrazolium violet + H2O
isoquinoline-1-one + reduced p-iodonitro-tetrazolium violet
-
-
-
-
?
quinoline + p-iodonitro-tetrazolium violet + H2O
isoquinoline-1-one + reduced p-iodonitro-tetrazolium violet
-
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(3-Methyl)-quinoline + acceptor + H2O
?
-
first step of 3-methylquinoline degradation
-
-
?
Quinoline + acceptor + H2O
?
-
first step of quinoline degradation
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
molybdopterin
-
the enzyme contains a molybdenum-molybdopterin cytosine dinucleotide cofactor
molybdopterin
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
molybdopterin
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
molybdopterin
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
molybdopterin
-
enzyme contains 2 molecules of molybdopterin cytosine dinucleotide
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Fe
Mo
Fe
-
enzyme contains 7.7 mol iron and 7.5 mol acid labile sulfur per mol of enzyme
Mo
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
Mo
-
clear correlation between the molybdenum cytosine dinucleotide molybdenum cofactor, the reduction of the enzyme by its substrate quinoline and the appearence of the Mo(V) rapid type Q EPR signal
Mo
-
measurement of the redox potentials of the molybdenum cofactor and the [2Fe-2S]clusters
Mo
-
the enzyme contains a molybdenum-molybdopterin cytosine dinucleotide cofactor
Mo
-
measurement of the redox potential of the molybdenum cofactor and the [2Fe-2S]clusters
Mo
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
Mo
-
molybdopterin cytosine dinucleotide is a part of the pterin molybdenum cofactor
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
OxoS
-
is required for quinoline-dependent transcription from PoxoO, Porf3, PqorM, and PoxoR
-
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
1.08
2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride
-
with quinoline as cosubstrate
0.182
Quinoline
-
with 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride as cosubstrate
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0057
-
substrate substrate pyrimidine-4-one, crude extract, pH 7.5, 25°C
additional information
additional information
specific activity of enzyme purified from strain KT2440 pUF1 is about 10% of the activity of enzyme purified from wild-type
additional information
specific activity of enzyme purified from strain KT2440 pUF1 is about 10% of the activity of enzyme purified from wild-type
additional information
specific activity of enzyme purified from strain KT2440 pUF1 is about 10% of the activity of enzyme purified from wild-type
additional information