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Information on EC 1.3.98.6 - AdoMet-dependent heme synthase for references in articles please use BRENDA:EC1.3.98.6
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IUBMB Comments This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
ahbD, SAM-dependent heme synthase,
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SAM-dependent heme synthase
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ahbD
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gene name
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Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine
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Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase.
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Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
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Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
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Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
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Fe-coproporphyrin III + S-adenosyl-L-methionine
protoheme + CO2 + 5'-deoxyadenosine + L-methionine
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[4Fe-4S]-center
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the enzyme contains two [4Fe-4S] clusters
S-adenosyl-L-methionine
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S-adenosyl-L-methionine
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Fe2+
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contains 8.5 mol iron per mol enzyme
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brenda
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brenda
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Blue Sepharose column chromatography and Mono Q column chromatography
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expressed in Escherichia coli
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expressed in Escherichia coli BL21(DE3) cells
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Kühner, M.; Haufschildt, K.; Neumann, A.; Storbeck, S.; Streif, J.; Layer, G.
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri
Archaea
2014
327637
2014
Methanosarcina barkeri
brenda
Bali, S.; Lawrence, A.; Lobo, S.; Saraiva, L.; Golding, B.; Palmer, D.; Howard, M.; Ferguson, S.; Warren, M.
Molecular hijacking of siroheme for the synthesis of heme and d1 heme
Proc. Natl. Acad. Sci. USA
108
18260-18265
2011
Desulfovibrio desulfuricans
brenda
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1.3.98.6 AdoMet-dependent heme synthase
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