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Information on EC 1.3.98.5 - hydrogen peroxide-dependent heme synthase

for references in articles please use BRENDA:EC1.3.98.5

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IUBMB Comments

The enzyme participates in a heme biosynthesis pathway found in Gram-positive bacteria. The initial decarboxylation step is fast and yields the three-propanoate harderoheme isomer III. The second decarboxylation is much slower. cf. EC 1.3.98.6, SAM-dependent heme synthase.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
Fe-coproporphyrin III
+
2
H2O2
=
protoheme
+
2
CO2
+
4
H2O
+
2
=
+
2
+
4

Synonyms
coproheme decarboxylase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Fe-coproporphyrin III + 2 H2O2 = protoheme + 2 CO2 + 4 H2O
show the reaction diagram
overall reaction
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-
-
Fe-coproporphyrin III + H2O2 = harderoheme III + CO2 + 2 H2O
show the reaction diagram
(1a)
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-
-
harderoheme III + H2O2 = protoheme + CO2 + 2 H2O
show the reaction diagram
(1b)
-
-
-
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