Disease on EC 1.3.98.3 - coproporphyrinogen dehydrogenase

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DISEASE
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Anemia
Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.
Asthma
Raised interferon ?, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma.
Atherosclerosis
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.
Bacterial Infections
Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens.
Viperin: a radical response to viral infection.
Carcinoma
Functional characterization of interferon regulatory factor 5 and its role in the innate antiviral immune response.
Central Nervous System Diseases
The interferon-inducible gene viperin restricts West Nile virus pathogenesis.
Central Nervous System Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Classical Swine Fever
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein.
coproporphyrinogen dehydrogenase deficiency
Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines.
Cytomegalovirus Infections
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.
Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.
Viperin turns coat in cytomegalovirus infection.
Dehydration
1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility.
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Dengue
A naturally occurring antiviral ribonucleotide encoded by the human genome.
Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus).
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Dwarfism
The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.
Encephalitis, Japanese
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells.
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Encephalitis, Tick-Borne
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Equine Infectious Anemia
Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.
Flavivirus Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Glucose Intolerance
Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation.
Hepatitis B
Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus.
Hepatitis C
A naturally occurring antiviral ribonucleotide encoded by the human genome.
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix.
The interferon inducible gene: Viperin.
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.
Viperin: a radical response to viral infection.
Hepatitis C, Chronic
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.
Herpes Simplex
Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41.
Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Chichen type III interferon produced by silkworm bioreactor induces ISG expression and restricts ALV-J infection in vitro.
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens.
Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway.
Gene expression profiles during in vivo human rhinovirus infection: insights into the host response.
Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41.
Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules.
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.
Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role.
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus.
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus.
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells.
Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection.
The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.
The infection of red seabream iridovirus in mandarin fish (Siniperca chuatsi) and the host immune related gene expression profiles.
The interferon inducible gene: Viperin.
The interferon-inducible gene viperin restricts West Nile virus pathogenesis.
The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells.
TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig5.
Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin.
Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1.
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.
Viperin controls chikungunya virus-specific pathogenic T cell IFN? Th1 stimulation in mice.
Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein.
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein.
Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells.
Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis.
Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.
Viperin restricts chikungunya virus replication and pathology.
Viperin turns coat in cytomegalovirus infection.
Influenza, Human
A naturally occurring antiviral ribonucleotide encoded by the human genome.
A novel anti-viral role for STAT3 in IFN-? signalling responses.
Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules.
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Influenza virus not cRAFTy enough to dodge viperin.
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo.
The interferon inducible gene: Viperin.
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.
[Advances in Avian Antiviral Innate Immune Effectors].
Lymphocytic Choriomeningitis
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Metabolic Diseases
Intrinsic expression of viperin regulates thermogenesis in adipose tissues.
Neoplasms
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Newcastle Disease
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Molecular characterization and expression analysis of the duck viperin gene.
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Porcine Reproductive and Respiratory Syndrome
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Pulmonary Disease, Chronic Obstructive
Reduced sputum expression of interferon-stimulated genes in severe COPD.
Rabies
A naturally occurring antiviral ribonucleotide encoded by the human genome.
Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Respiratory Tract Infections
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
ST Elevation Myocardial Infarction
Identification of a circulating microvesicle protein network involved in ST-elevation myocardial infarction.
Vesicular Stomatitis
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Viremia
The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.
Virus Diseases
Characterisation of chicken viperin.
Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle.
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?
Dynamic Changes in Host Gene Expression following
Equine herpesvirus-1 suppresses type-I interferon induction in equine endothelial cells.
Grouper viperin acts as a crucial antiviral molecule against iridovirus.
Identification and functional characterization of viperin of amphioxus Branchiostoma japonicum: Implications for ancient origin of viperin-mediated antiviral response.
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo.
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection.
Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus).
Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation.
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells.
The interferon-inducible gene viperin restricts West Nile virus pathogenesis.
The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication.
The Role of Viperin in Antiflavivirus Responses.
The role of viperin in the innate antiviral response.
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis.
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Viperin: a radical response to viral infection.
Yellow Fever
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Zika Virus Infection
Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin.
Viperin is an important host restriction factor in control of Zika virus infection.