Disease on EC 1.3.98.3 - coproporphyrinogen dehydrogenase
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Anemia
Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.
Asthma
Raised interferon ?, type 3 interferon and interferon stimulated genes - evidence of innate immune activation in neutrophilic asthma.
Atherosclerosis
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.
Bacterial Infections
Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens.
Bacterial Infections
The interferon stimulated gene viperin, restricts Shigella. flexneri in vitro.
Carcinoma
Functional characterization of interferon regulatory factor 5 and its role in the innate antiviral immune response.
Central Nervous System Diseases
The interferon-inducible gene viperin restricts West Nile virus pathogenesis.
Central Nervous System Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Classical Swine Fever
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Classical Swine Fever
Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein.
Coinfection
Impact of Aeromonas hydrophila and infectious spleen and kidney necrosis virus infections on susceptibility and host immune response in Chinese perch (Siniperca chuatsi).
coproporphyrinogen dehydrogenase deficiency
Viperin Deficiency Promotes Polarization of Macrophages and Secretion of M1 and M2 Cytokines.
Cytomegalovirus Infections
The antiviral cytomegalovirus inducible gene 5/viperin is expressed in atherosclerosis and regulated by proinflammatory agents.
Cytomegalovirus Infections
Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.
Dehydration
1,2-Diol Dehydration by the Radical SAM Enzyme AprD4: A Matter of Proton Circulation and Substrate Flexibility.
Dehydration
Mechanism of Diol Dehydration by a Promiscuous Radical-SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2).
Dehydration
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Dengue
Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus).
Dengue
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Dwarfism
The anti-viral protein viperin regulates chondrogenic differentiation via CXCL10 protein secretion.
Encephalitis, Japanese
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells.
Encephalitis, Japanese
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Encephalitis, Tick-Borne
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity.
Encephalitis, Tick-Borne
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Equine Infectious Anemia
Equine viperin restricts equine infectious anemia virus replication by inhibiting the production and/or release of viral Gag, Env, and receptor via distortion of the endoplasmic reticulum.
Flavivirus Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Glucose Intolerance
Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation.
Hepatitis B
Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus.
Hepatitis C
Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation.
Hepatitis C
The antiviral protein viperin inhibits hepatitis C virus replication via interaction with nonstructural protein 5A.
Hepatitis C
The antiviral protein, viperin, localizes to lipid droplets via its N-terminal amphipathic alpha-helix.
Hepatitis C
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein hVAP-33.
Hepatitis C, Chronic
Analysis of ISG expression in chronic hepatitis C identifies viperin as a potential antiviral effector.
Herpes Simplex
Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41.
Herpes Simplex
The Interaction Mechanism Between Herpes Simplex Virus 1 Glycoprotein D and Host Antiviral Protein Viperin.
Herpes Simplex
Viperin has species-specific roles in response to herpes simplex virus infection.
Herpes Zoster
Host-Pathogen Responses to Pandemic Influenza H1N1pdm09 in a Human Respiratory Airway Model.
Infections
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin.
Infections
Chichen type III interferon produced by silkworm bioreactor induces ISG expression and restricts ALV-J infection in vitro.
Infections
Dengue virus infects the mouse eye following systemic or intracranial infection and induces inflammatory responses.
Infections
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
Infections
Differential immunomodulatory effect of vitamin D (1,25 (OH)2 D3) on the innate immune response in different types of cells infected in vitro with infectious bursal disease virus.
Infections
Differential regulation of Sciaenops ocellatus viperin expression by intracellular and extracellular bacterial pathogens.
Infections
Dynamic Changes in the Expression of Interferon-Stimulated Genes in Joints of SPF Chickens Infected With Avian Reovirus.
Infections
Fish viperin exerts a conserved antiviral function through RLR-triggered IFN signaling pathway.
Infections
Gene expression profiles during in vivo human rhinovirus infection: insights into the host response.
Infections
Herpes simplex virus 1 counteracts viperin via its virion host shutoff protein UL41.
Infections
Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules.
Infections
HIV-1 infection of human macrophages directly induces viperin which inhibits viral production.
Infections
Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.
Infections
Human Viperin Causes Radical SAM-Dependent Elongation of Escherichia coli, Hinting at Its Physiological Role.
Infections
Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.
Infections
Identification of three interferon-inducible cellular enzymes that inhibit the replication of hepatitis C virus.
Infections
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Infections
In vitro and in vivo roles of sphingosine kinase 2 during dengue virus infection.
Infections
Intracranial Injection of Dengue Virus Induces Interferon Stimulated Genes and CD8+ T Cell Infiltration by Sphingosine Kinase 1 Independent Pathways.
Infections
Involvement of viperin in prevention of intrauterine transmission of hepatitis B virus.
Infections
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Infections
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Infections
Rhinovirus replication and innate immunity in highly differentiated human airway epithelial cells.
Infections
Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection.
Infections
The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.
Infections
The infection of red seabream iridovirus in mandarin fish (Siniperca chuatsi) and the host immune related gene expression profiles.
Infections
The neuropathogenic T953 strain of equine herpesvirus-1 inhibits type-I IFN mediated antiviral activity in equine endothelial cells.
Infections
TLR3 Ligation Activates an Antiviral Response in Human Fetal Astrocytes: A Role for Viperin/cig5.
Infections
Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin.
Infections
Transcriptional activation of interferon-stimulated genes but not of cytokine genes after primary infection of rhesus macaques with dengue virus type 1.
Infections
Transcriptomic Analysis and Functional Characterization Reveal the Duck Interferon Regulatory Factor 1 as an Important Restriction Factor in the Replication of Tembusu Virus.
Infections
TRK-Fused Gene (TFG), a protein involved in protein secretion pathways, is an essential component of the antiviral innate immune response.
Infections
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus.
Infections
Viperin controls chikungunya virus-specific pathogenic T cell IFN? Th1 stimulation in mice.
Infections
Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types.
Infections
Viperin has species-specific roles in response to herpes simplex virus infection.
Infections
Viperin Inhibits Classical Swine Fever Virus Replication by Interacting with Viral Non-structural 5A Protein.
Infections
Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein.
Infections
Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Infections
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Infections
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Infections
Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells.
Infections
Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis.
Infections
Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein.
Infections
Viperin regulates cellular lipid metabolism during human cytomegalovirus infection.
Infections
Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis.
Infections
Viperin_sv1 promotes RIG-I expression and suppresses SVCV replication through its radical SAM domain.
Influenza, Human
A naturally occurring antiviral ribonucleotide encoded by the human genome.
Influenza, Human
Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules.
Influenza, Human
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Influenza, Human
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo.
Influenza, Human
The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts.
Lymphocytic Choriomeningitis
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Metabolic Diseases
Intrinsic expression of viperin regulates thermogenesis in adipose tissues.
Neoplasms
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Newcastle Disease
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.
Newcastle Disease
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Newcastle Disease
Molecular characterization and expression analysis of the duck viperin gene.
Newcastle Disease
Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro.
Paramyxoviridae Infections
Viperin protein inhibits the replication of caprine parainfluenza virus 3 (CPIV 3) by interaction with viral N protein.
Porcine Reproductive and Respiratory Syndrome
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Pulmonary Disease, Chronic Obstructive
Reduced sputum expression of interferon-stimulated genes in severe COPD.
Rabies
Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4.
Respiratory Tract Infections
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
ring-type e3 ubiquitin transferase deficiency
Targeting UBE4A Revives Viperin Protein in Epithelium to Enhance Host Antiviral Defense.
Rotavirus Infections
Viperin, an IFN-Stimulated Protein, Delays Rotavirus Release by Inhibiting Non-Structural Protein 4 (NSP4)-Induced Intrinsic Apoptosis.
Spasm
Electron Paramagnetic Resonance Spectroscopic Identification of the Fe-S Clusters in the SPASM Domain-Containing Radical SAM Enzyme PqqE.
ST Elevation Myocardial Infarction
Identification of a circulating microvesicle protein network involved in ST-elevation myocardial infarction.
Vesicular Stomatitis
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Viremia
The antiviral mechanism of viperin and its splice variant in spring viremia of carp virus infected fathead minnow cells.
Virus Diseases
Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle.
Virus Diseases
Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.
Virus Diseases
Detection of Host Response to Viral Respiratory Infection by Measurement of Messenger RNA for MxA, TRIM21, and Viperin in Nasal Swabs.
Virus Diseases
Does Viperin Function as a Radical S-Adenosyl-l-methionine-dependent Enzyme in Regulating Farnesylpyrophosphate Synthase Expression and Activity?
Virus Diseases
Equine herpesvirus-1 suppresses type-I interferon induction in equine endothelial cells.
Virus Diseases
Identification and functional characterization of viperin of amphioxus Branchiostoma japonicum: Implications for ancient origin of viperin-mediated antiviral response.
Virus Diseases
IFN regulatory factor-1 bypasses IFN-mediated antiviral effects through viperin gene induction.
Virus Diseases
In vivo and in vitro studies on the antiviral activities of viperin against influenza H1N1 virus infection.
Virus Diseases
Inhibition of African Swine Fever Virus Replication by Porcine Type I and Type II Interferons.
Virus Diseases
Investigating the efficacy of pamidronate, a chemical inhibitor of farnesyl pyrophosphate synthase, in the inhibition of influenza virus infection in vitro and in vivo.
Virus Diseases
Monkey Viperin Restricts Porcine Reproductive and Respiratory Syndrome Virus Replication.
Virus Diseases
Rock bream (Oplegnathus fasciatus) viperin is a virus-responsive protein that modulates innate immunity and promotes resistance against megalocytivirus infection.
Virus Diseases
Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus).
Virus Diseases
Targeting viperin improves diet-induced glucose intolerance but not adipose tissue inflammation.
Virus Diseases
The cellular antiviral protein viperin is attenuated by proteasome-mediated protein degradation in Japanese encephalitis virus-infected cells.
Virus Diseases
The interferon-inducible gene viperin restricts West Nile virus pathogenesis.
Virus Diseases
The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication.
Virus Diseases
Viperin has species-specific roles in response to herpes simplex virus infection.
Virus Diseases
Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response.
Virus Diseases
Viperin Is Highly Induced in Neutrophils and Macrophages during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection.
Virus Diseases
Viperin is induced following dengue virus type-2 (DENV-2) infection and has anti-viral actions requiring the C-terminal end of viperin.
Virus Diseases
Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis.
Virus Diseases
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Virus Diseases
Viperin, through its radical-SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication.
Virus Diseases
Viperin: An ancient radical SAM enzyme finds its place in modern cellular metabolism and innate immunity.
Yellow Fever
Viperin Restricts Zika Virus and Tick-Borne Encephalitis Virus Replication by Targeting NS3 for Proteasomal Degradation.
Zika Virus Infection
Toll-like receptor agonist R848 blocks Zika virus replication by inducing the antiviral protein viperin.
Zika Virus Infection
Viperin is an important host restriction factor in control of Zika virus infection.
Zika Virus Infection
Zika virus infection of first trimester trophoblast cells affects cell migration, metabolism and immune homeostasis control.
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