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Information on EC 1.3.8.9 - very-long-chain acyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.9

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IUBMB Comments

Contains FAD as prosthetic group. One of several enzymes that catalyse the first step in fatty acids β-oxidation. The enzyme is most active toward long-chain acyl-CoAs such as C14, C16 and C18, but is also active with very-long-chain acyl-CoAs up to 24 carbons. It shows no activity for substrates of less than 12 carbons. Its specific activity towards palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase . cf. EC 1.3.8.1, short-chain acyl-CoA dehydrogenase, EC 1.3.8.7, medium-chain acyl-CoA dehydrogenase, and EC 1.3.8.8, long-chain acyl-CoA dehydrogenase.

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
vlcadd, acadvl, very-long-chain acyl-coa dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain acyl-CoA + electron-transfer flavoprotein = a very-long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(8E,10E)-dodeca-8,10-dienol biosynthesis, Spodoptera littoralis pheromone biosynthesis
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