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Information on EC 1.3.8.5 - short-chain 2-methylacyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.5

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IUBMB Comments

A flavoprotein (FAD). The mammalian enzyme catalyses an oxidative reaction as a step in the mitochondrial β-oxidation of short-chain 2-methyl fatty acids and participates in isoleucine degradation. The enzyme from the parasitic helminth Ascaris suum catalyses a reductive reaction as part of a fermentation pathway, shuttling reducing power from the electron-transport chain to 2-methyl branched-chain enoyl CoA.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

Synonyms
sbcad, sbcadd, short/branched chain acyl-coa dehydrogenase, 2-methylbutyryl-coa dehydrogenase, 2mbcd, 2-methyl branched-chain acyl-coa dehydrogenase, 2-methyl branched-chain enoyl-coa reductase, 2-methyl branched-chain enoyl coa reductase, 2-methyl branched chain acyl-coa dehydrogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-methylbutanoyl-CoA + electron-transfer flavoprotein = (E)-2-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein + H+
show the reaction diagram
Highest Expressing Human Cell Lines
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