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Information on EC 1.3.8.4 - isovaleryl-CoA dehydrogenase
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EC Tree
1.3.8.4 isovaleryl-CoA dehydrogenaseIUBMB Comments
Contains FAD as prosthetic group. Pentanoate can act as donor.
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Word Map
- 1.3.8.4
-
acidemia
- acyl-coa
-
inborn
- 3-methylcrotonyl-coa
-
isovalerylglycine
-
medium-chain
-
lethargy
-
flavoenzyme
- isobutyryl-coa
- acylcarnitine
- isovalerylcarnitine
-
flavoprotein:ubiquinone
- glutaryl-coa
- 2-methylbutyryl-coa
-
3-hydroxyisovaleric
- octanoyl-coa
-
sweaty
- diagnostics
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
isovaleryl-coa dehydrogenase, isovaleryl-coenzyme a dehydrogenase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
EC 1.3.99.10
-
-
formerly
-
isovaleroyl-coenzyme A dehydrogenase
-
-
-
-
isovaleryl-coenzyme A dehydrogenase
-
-
-
-
IVD
IVDH
Pden_3633
IVD
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
3-methylbutanoyl-CoA + electron-transfer flavoprotein = 3-methylbut-2-enoyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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-
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SYSTEMATIC NAME
IUBMB Comments
3-methylbutanoyl-CoA:electron-transfer flavoprotein oxidoreductase
Contains FAD as prosthetic group. Pentanoate can act as donor.
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CAS REGISTRY NUMBER
COMMENTARY
37274-61-6
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(S)-2-methylbutyryl-CoA + electron-transfer flavoprotein
2-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
2-methyl-hexanoyl-CoA + acceptor
2-methylhex-2-enoyl-CoA + reduced acceptor
-
4% relative activity to isovaleryl-CoA
-
?
2-methylbutanoyl-CoA + acceptor
2-methylbut-2-enoyl-CoA + reduced acceptor
-
low activity with the wild-type and mutant L95V/A99V/L103V/L370M/G374A
-
-
?
butyryl-CoA + 2,6-dichlorophenolindophenol
?
-
high substrate specificity
-
-
?
butyryl-CoA + electron-transfer flavoprotein
crotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
hexanoyl-CoA + electron-transfer flavoprotein
hex-2-enoyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + 2,6-dichlorophenolindophenol
?
-
high substrate specificity
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonoyl-CoA + reduced electron transfer protein
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
isovaleryl-CoA + phenazine methosulfate
3-methylcrotonyl-CoA + reduced phenazine methosulfate
2-methylpalmitoyl-CoA + acceptor
2-methylhexadec-2-enoyl-CoA + reduced acceptor
-
7% relative activity to isovaleryl-CoA
-
?
2-methylpalmitoyl-CoA + acceptor
2-methylhexadec-2-enoyl-CoA + reduced acceptor
-
minor activity
-
?
2-methylpalmitoyl-CoA + acceptor
2-methylhexadec-2-enoyl-CoA + reduced acceptor
-
minor activity
-
?
2-methylpalmitoyl-CoA + acceptor
2-methylhexadec-2-enoyl-CoA + reduced acceptor
-
minor activity
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
-
electron acceptor: electron-transferring flavoprotein
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
-
acceptor: phenazine methosulfate
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
-
21% relative specific activity to isovaleryl-CoA
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
-
3.3% relative activity to isovaleryl-CoA
-
?
butyryl-CoA + acceptor
but-2-enoyl-CoA + reduced acceptor
low activity
-
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
-
weak activity
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
-
electron acceptor: electron-transferring flavoprotein
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
-
acceptor: phenazine methosulfate
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
-
15% relative specific activity to isovaleryl-CoA
-
?
hexanoyl-CoA + acceptor
hex-2-enoyl-CoA + reduced acceptor
low activity
-
-
?
isobutyryl-CoA + acceptor
2-methylpropanoyl-CoA + reduced acceptor
-
20% relative activity to isovaleryl-CoA
-
?
isobutyryl-CoA + acceptor
2-methylpropanoyl-CoA + reduced acceptor
-
the activity with isobutyryl-CoA implies an additional role of the enzyme in the catabolism of valine
-
?
isobutyryl-CoA + acceptor
2-methylpropanoyl-CoA + reduced acceptor
-
the activity with isobutyryl-CoA implies an additional role of the enzyme in the catabolism of valine
-
?
isobutyryl-CoA + acceptor
2-methylpropanoyl-CoA + reduced acceptor
-
the activity with isobutyryl-CoA implies an additional role of the enzyme in the catabolism of valine
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: ferricenium hexafluorophosphate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: electron-transferring flavoprotein
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
enzyme activity observed in the absence of electron transfer agents suggests that rapid tritium exchange occurs between the enzyme-bound substrate and the incubation medium
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
the catalytic activity of the recombinant wild-type enzyme is the highest in the presence of isovaleryl-CoA
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
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electron acceptor: electron-transferring flavoprotein
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
electron acceptor: electron-transferring flavoprotein, dichlorophenol indophenol or dichlorophenol indophenol + FAD
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
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?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
acceptors: electron-transfer flavoprotein, phenazine methosulfate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
isovaleryl-CoA is the preferred substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: 2,6-dichloroindophenol, intermediate electron carrier: phenazine methosulfate
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonoyl-CoA + reduced electron transfer protein
-
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonoyl-CoA + reduced electron transfer protein
acceptor porcine electron transfer protein
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
-
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
best substrate
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
reaction via an alpha,beta-dehydrogenation step
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
r
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + FAD
3-methylcrotonyl-CoA + FADH2
with ferrocenium hexafluorophosphate as second electron acceptor
-
-
?
isovaleryl-CoA + phenazine methosulfate
3-methylcrotonyl-CoA + reduced phenazine methosulfate
-
-
-
-
?
isovaleryl-CoA + phenazine methosulfate
3-methylcrotonyl-CoA + reduced phenazine methosulfate
-
-
-
-
?
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
-
electron acceptor: electron-transferring flavoprotein
-
?
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
-
46% relative specific activity to isovaleryl-CoA
-
?
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
-
-
-
?
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
-
-
-
?
n-valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
-
32% relative specific activity to isovaleryl-CoA
-
?
octanoyl-CoA + acceptor
oct-2-enoyl-CoA + reduced acceptor
-
7% relative activity to isovaleryl-CoA
-
?
octanoyl-CoA + acceptor
oct-2-enoyl-CoA + reduced acceptor
-
1% relative specific activity to isovaleryl-CoA
-
?
octanoyl-CoA + acceptor
oct-2-enoyl-CoA + reduced acceptor
very low activity
-
-
?
valeryl-CoA + acceptor
pent-2-enoyl-CoA + reduced acceptor
low activity
-
-
?
additional information
?
-
-
the presence of a putative enzyme supports functional leucine catabolism in plant mitochondria
-
-
?
additional information
?
-
activity measurement using an acyl-CoA substrate and 2,6-dichloroindophenol as an electron acceptor, with phenazinemethosulfate as an intermediate electron carrier
-
-
?
additional information
?
-
-
activity measurement using an acyl-CoA substrate and 2,6-dichloroindophenol as an electron acceptor, with phenazinemethosulfate as an intermediate electron carrier
-
-
?
additional information
?
-
activity measurement using an acyl-CoA substrate and 2,6-dichloroindophenol as an electron acceptor, with phenazinemethosulfate as an intermediate electron carrier
-
-
?
additional information
?
-
activity measurement using an acyl-CoA substrate and 2,6-dichloroindophenol as an electron acceptor, with phenazinemethosulfate as an intermediate electron carrier
-
-
?
additional information
?
-
-
substrate specificity of wild-type and mutant enzymes
-
-
?
additional information
?
-
-
deficiency of the enzyme in humans is responsible for isovaleric acidemia
-
-
?
additional information
?
-
deficiency of the enzyme in humans is responsible for isovaleric acidemia
-
-
?
additional information
?
-
-
deficiency of the enzyme in humans is responsible for isovaleric acidemia
-
-
?
additional information
?
-
-
E254 of the enzyme is in close proximity to the bound FAD, E254 is the active site catalytic residue
-
-
?
additional information
?
-
-
E254 of the enzyme is in close proximity to the bound FAD, E254 is the active site catalytic residue
-
-
?
additional information
?
-
-
the location of the catalytic residue together with a glycine at position 374 is important for conferring branched-chain substrate specificity to the enzyme
-
-
?
additional information
?
-
-
R387 has an important role in anchoring the substrate
-
-
?
additional information
?
-
-
the type III enzyme mutation responsible for isovaleric acidemia leads to a shift in reading frame and the subsequent incorporation of eight abnormally placed amino acids with premature termination of translation
-
-
?
additional information
?
-
-
a specific deficiency of enzyme activity is observed in cultured skin fibroblasts from patients with isovaleric acidemia
-
-
?
additional information
?
-
-
a specific deficiency of enzyme activity is observed in cultured skin fibroblasts from patients with isovaleric acidemia
-
-
?
additional information
?
-
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
-
physiological implications of enzyme mutations and deficiency
-
-
?
additional information
?
-
-
isovaleric acidemia is a rare recessive autosomal disorder, caused by isovaleryl-CoA dehydrogenase (IVD) deficiency
-
-
?
additional information
?
-
-
Glu-244 is the catalytic base responsible for abstracting the alpha-proton of substrate
-
-
?
additional information
?
-
-
the enzyme is required in the leucine/isovalerate utilization, Liu, pathway for growth of Pseudomonas aeruginosa on acyclic terpene alcohols (citronellol) and on other methyl-branched compounds such as leucine or isovalerate, Liu proteins in metabolism of methyl-branched compounds, overview
-
-
?
additional information
?
-
-
no activity of LiuA with isobutyryl-CoA, 3-hydroxybutyryl-CoA, octanoyl-CoA, citronellyl-CoA or 5-methyl-hex-4-enoyl-CoA
-
-
?
additional information
?
-
-
the enzyme catalyzes the third step of the leucine oxidative metabolism
-
-
?
additional information
?
-
the enzyme catalyzes the dehydrogenation of monomethyl branched-chain fatty acid thioester derivatives
-
-
?
additional information
?
-
broader substrate specificity, overview. The enzyme is also active with octanoyl-CoA, decanoyl-CoA, and dodecanoyl-CoA. No activity with isobutyryl-CoA and myristoyl-CoA, with DCIPIP and phenazine methosulfate as second electron acceptors
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
isovaleryl-CoA + 2,6-dichlorophenolindophenol
?
-
high substrate specificity
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonoyl-CoA + reduced electron transfer protein
-
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
electron acceptor: electron-transfer flavoprotein serves as a natural electron acceptor for the enzyme with isovaleryl-CoA as substrate
-
?
isovaleryl-CoA + acceptor
3-methylcrotonyl-CoA + reduced acceptor
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
-
-
-
-
?
isovaleryl-CoA + electron transfer protein
3-methylcrotonyl-CoA + reduced electron transfer protein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
isovaleryl-CoA + electron-transfer flavoprotein
3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
-
-
?
additional information
?
-
-
the presence of a putative enzyme supports functional leucine catabolism in plant mitochondria