We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Information on EC 1.3.8.3 - (R)-benzylsuccinyl-CoA dehydrogenase for references in articles please use BRENDA:EC1.3.8.3
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.
The enzyme appears in viruses and cellular organisms
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
BbsG
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase
Requires FAD as prosthetic group. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
(R)-2-benzylsuccinyl-CoA + ferricenium hexafluorophosphate
(E)-2-benzylidenesuccinyl-CoA + ferrocenium hexafluorophosphate
-
low activity with a mixture of phenazine methosulfate/dichlorophenol indophenol, no activity with NAD+, NADP+, dichlorophenolindophenol, ferricyanide or tetrazolium as electron acceptors, very low activity with valeryl-CoA and octanoyl-CoA
-
?
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
-
-
-
-
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
highly specific for (R)-benzylsuccinyl-CoA
-
-
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
no activity with benzylsuccinate or succinyl-CoA
-
?
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
involved in anaerobic toluene oxidation to benzoyl-CoA
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
-
-
-
-
(R)-2-benzylsuccinyl-CoA + electron-transferring flavoprotein
(E)-2-benzylidenesuccinyl-CoA + reduced electron-transferring flavoprotein
-
involved in anaerobic toluene oxidation to benzoyl-CoA
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
FAD
-
no FMN or riboflavin detected
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(S)-benzylsuccinyl-CoA
-
complete inhibition
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.11
(R)-2-benzylsuccinyl-CoA
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
strains T and M3, grown on toluene or m-xylene
-
-
brenda
grown on toluene
-
-
brenda
grown on toluene
-
-
brenda
-
Q39VG7
UniProt
brenda
-
Q39VG7
UniProt
brenda
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
physiological function
Q39VG7
deletion of the BbsG gene has little impact on degradation of para-cresol. Geobacillus metallireducens uses a methylhydroxylase-initiated pathway for p-cresol degradation
physiological function
-
deletion of the BbsG gene has little impact on degradation of para-cresol. Geobacillus metallireducens uses a methylhydroxylase-initiated pathway for p-cresol degradation
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
45000
-
alpha4, 4 * 45000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
tetramer
-
alpha4, 4 * 45000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Q-Sepharose, hydroxyapatite, butyl-Fractogel, Superdex HR200, recombinant enzyme
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
expression in Escherichia coli
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Leuthner, B.; Heider, J.
Anaerobic toluene catabolism of Thauera aromatica: the bbs operon codes for enzymes of b oxidation of the intermediate benzylsuccinate
J. Bacteriol.
182
272-277
2000
Thauera aromatica
brenda
Leutwein, C.; Heider, J.
(R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway
Arch. Microbiol.
178
517-524
2002
Azoarcus sp., Azoarcus tolulyticus, Azoarcus tolulyticus B5, Thauera aromatica
brenda
Chaurasia, A.K.; Tremblay, P.L.; Holmes, D.E.; Zhang, T.
Genetic evidence that the degradation of para-cresol by Geobacter metallireducens is catalyzed by the periplasmic para-cresol methylhydroxylase
FEMS Microbiol. Lett.
362
pii: fnv145
2015
Geobacter metallireducens (Q39VG7), Geobacter metallireducens DSM 7210 (Q39VG7)
brenda
Select items on the left to see more content.
html completed
HOME
login
history
all enzymes
BRENDA home
History
1.3.8.3 (R)-benzylsuccinyl-CoA dehydrogenase
more
top
Information
