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Information on EC 1.3.8.12 - (2S)-methylsuccinyl-CoA dehydrogenase

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EC Tree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.8 With a flavin as acceptor

1.3.8.12 (2S)-methylsuccinyl-CoA dehydrogenase

IUBMB Comments

The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.

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The expected taxonomic range for this enzyme is: Rhodobacter sphaeroides

Reaction Schemes

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(2S)-methylsuccinyl-CoA

electron-transfer flavoprotein

2-methylfumaryl-CoA

reduced electron-transfer flavoprotein

Synonyms

MCD,

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

MCD

Rhodobacter sphaeroides

D3JV03

730403

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein = 2-methylfumaryl-CoA + reduced electron-transfer flavoprotein

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PATHWAY SOURCE

PATHWAYS

BRENDA

ethylmalonyl-CoA pathway

KEGG

Glyoxylate and dicarboxylate metabolism, Microbial metabolism in diverse environments

MetaCyc

ethylmalonyl-CoA pathway

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SYSTEMATIC NAME

IUBMB Comments

(2S)-methylsuccinyl-CoA:electron-transfer flavoprotein oxidoreductase

The enzyme, characterized from the bacterium Rhodobacter sphaeroides, is involved in the ethylmalonyl-CoA pathway for acetyl-CoA assimilation. The enzyme contains FAD.

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein

2-methylfumaryl-CoA + reduced electron-transfer flavoprotein

2 entries

(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein

2-methylfumaryl-CoA + reduced electron-transfer flavoprotein

Rhodobacter sphaeroides

D3JV03

the enzyme is involved ion the ethylmalonyl-CoA pathway for acetyl-CoA assimilation

730403

(2S)-methylsuccinyl-CoA + electron-transfer flavoprotein

2-methylfumaryl-CoA + reduced electron-transfer flavoprotein

Rhodobacter sphaeroides

D3JV03

the enzyme is highly specific for (S)-methylsuccinyl-CoA. No activity with butyryl-CoA, isobutyryl-CoA or a diastereomeric mixture of (R)-methylsuccinyl-CoA

730403

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)