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Information on EC 1.3.8.10 - cyclohex-1-ene-1-carbonyl-CoA dehydrogenase

for references in articles please use BRENDA:EC1.3.8.10

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EC Tree

1 Oxidoreductases

1.3 Acting on the CH-CH group of donors

1.3.8 With a flavin as acceptor

1.3.8.10 cyclohex-1-ene-1-carbonyl-CoA dehydrogenase

IUBMB Comments

Contains FAD. The enzyme, characterized from the strict anaerobic bacterium Syntrophus aciditrophicus, is involved in production of cyclohexane-1-carboxylate, a byproduct produced by that organism during fermentation of benzoate and crotonate to acetate.

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The enzyme appears in viruses and cellular organisms

Reaction Schemes

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cyclohex-1-ene-1-carbonyl-CoA

electron-transfer flavoprotein

cyclohex-1,5-diene-1-carbonyl-CoA

reduced electron-transfer flavoprotein

Synonyms

Ch1CoA dehydrogenase, cyclohex-1-ene-1-carboxyl-CoA dehydrogenase, cyclohexanecarboxyl-CoA dehydrogenase, Gmet_3306, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Ch1CoA dehydrogenase

2 entries

cyclohex-1-ene-1-carboxyl-CoA dehydrogenase

2 entries

cyclohexanecarboxyl-CoA dehydrogenase

2 entries

Gmet_3306

2 entries

Ch1CoA dehydrogenase

Syntrophus aciditrophicus

725285

Ch1CoA dehydrogenase

Syntrophus aciditrophicus SB

cyclohex-1-ene-1-carboxyl-CoA dehydrogenase

Syntrophus aciditrophicus

725285

cyclohex-1-ene-1-carboxyl-CoA dehydrogenase

Syntrophus aciditrophicus SB

cyclohexanecarboxyl-CoA dehydrogenase

Syntrophus aciditrophicus

725285

cyclohexanecarboxyl-CoA dehydrogenase

Syntrophus aciditrophicus SB

Gmet_3306

Geobacter metallireducens

Q39QF5

742783

Gmet_3306

Geobacter metallireducens DSM 7210

Q39QF5

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

cyclohex-1-ene-1-carbonyl-CoA + electron-transfer flavoprotein = cyclohex-1,5-diene-1-carbonyl-CoA + reduced electron-transfer flavoprotein

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PATHWAY SOURCE

PATHWAYS

BRENDA

benzoyl-CoA degradation

KEGG

Benzoate degradation, Microbial metabolism in diverse environments

MetaCyc

benzoate fermentation (to acetate and cyclohexane carboxylate), benzoyl-CoA degradation III (anaerobic), crotonate fermentation (to acetate and cyclohexane carboxylate)

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SYSTEMATIC NAME

IUBMB Comments

cyclohex-1-ene-1-carbonyl-CoA:electron transfer flavoprotein oxidoreductase

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate+

benzoyl-CoA + ferrocenium hexafluorophosphate

2 entries

cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate

cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate

2 entries

cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate

cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate

4 entries

cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate

benzoyl-CoA + ferrocenium hexafluorophosphate

2 entries

additional information

4 entries

cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate+

benzoyl-CoA + ferrocenium hexafluorophosphate

Geobacter metallireducens

Q39QF5

742783

cyclohex-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate+

benzoyl-CoA + ferrocenium hexafluorophosphate

Geobacter metallireducens DSM 7210

Q39QF5

742783

cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate

cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate

Syntrophus aciditrophicus

Ti(III) citrate (5mM) in the presence of methyl viologen (1 mM) serves as the electron donor

725285

cyclohex-1,5-diene-1-carbonyl-CoA + Ti(III) citrate

cyclohex-1-ene-1-carbonyl-CoA + oxidized Ti(III) citrate

Syntrophus aciditrophicus SB

Ti(III) citrate (5mM) in the presence of methyl viologen (1 mM) serves as the electron donor

725285

cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate

cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate

Geobacter metallireducens

Q39QF5

742783

cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate

cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate

Geobacter metallireducens DSM 7210

Q39QF5

742783

cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate

cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate

Syntrophus aciditrophicus

725285

cyclohex-1-ene-1-carbonyl-CoA + ferricenium hexafluorophosphate

cyclohex-1,5-diene-1-carbonyl-CoA + ferrocenium hexafluorophosphate

Syntrophus aciditrophicus SB

725285

cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate

benzoyl-CoA + ferrocenium hexafluorophosphate

Syntrophus aciditrophicus

725285

cyclohexa-1,5-diene-1-carbonyl-CoA + ferricenium hexafluorophosphate

benzoyl-CoA + ferrocenium hexafluorophosphate

Syntrophus aciditrophicus SB

725285

additional information

Geobacter metallireducens

Q39QF5

no substrates: cyclohexanoyl-CoA, cyclohex-2-ene-1-carboxyl-CoA, cyclohex-3-ene-1-carboxyl-CoA, butanoyl-CoA, nor crotonyl-CoA

742783

additional information

Geobacter metallireducens DSM 7210

Q39QF5

no substrates: cyclohexanoyl-CoA, cyclohex-2-ene-1-carboxyl-CoA, cyclohex-3-ene-1-carboxyl-CoA, butanoyl-CoA, nor crotonyl-CoA

742783

additional information

Syntrophus aciditrophicus

no activity with ChCoA, 6-hydroxycyclohex-1-en-1-carboxyl-CoA, butyryl-CoA, glutaryl-CoA, succinyl-CoA, or cyclohexane carboxylate

725285

additional information

Syntrophus aciditrophicus SB

no activity with ChCoA, 6-hydroxycyclohex-1-en-1-carboxyl-CoA, butyryl-CoA, glutaryl-CoA, succinyl-CoA, or cyclohexane carboxylate

725285

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

FAD

Syntrophus aciditrophicus

725285

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.019 - 0.085

cyclohex-1,5-diene-1-carbonyl-CoA

2 entries

0.005 - 0.031

cyclohex-1-ene-1-carbonyl-CoA

2 entries

0.019

cyclohex-1,5-diene-1-carbonyl-CoA

Syntrophus aciditrophicus

at pH 7.0 and 30°C

725285

0.085

cyclohex-1,5-diene-1-carbonyl-CoA

Geobacter metallireducens

Q39QF5

pH 6.8, 30°C

742783

0.005

cyclohex-1-ene-1-carbonyl-CoA

Syntrophus aciditrophicus

Km less than 0.005 mM, at pH 7.0 and 30°C

725285

0.031

cyclohex-1-ene-1-carbonyl-CoA

Geobacter metallireducens

Q39QF5

pH 6.8, 30°C

742783

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Geobacter metallireducens

Q39QF5

substrate cyclohex-1,5-diene-1-carbonyl-CoA, pH 6.8, 30°C

742783

2.1

Syntrophus aciditrophicus

using (E)-2-cyclohex-1,5-diene-1-carbonyl-CoA as substrate, at pH 7.0 and 30°C

725285

2.3

Geobacter metallireducens

Q39QF5

substrate cyclohex-1-ene-1-carbonyl-CoA, pH 6.8, 30°C

742783

9.5

Syntrophus aciditrophicus

using cyclohex-1-ene-1-carbonyl-CoA as substrate, at pH 7.0 and 30°C

725285

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Geobacter metallireducens

742783

Q39QF5

UniProt

brenda

Geobacter metallireducens DSM 7210

742783

Q39QF5

UniProt

brenda

Syntrophus aciditrophicus

725285

brenda

Syntrophus aciditrophicus SB

725285

brenda

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

2 entries

physiological function

Geobacter metallireducens

Q39QF5

Geobacter metallireducens grows exponentially with cyclohexane carboxylic acid as the sole carbon source and nitrate as a terminal electron acceptor. Cyclohexane carboxylic acid degradation involves its activation by a succinyl-CoA-dependent CoA transferase followed by the oxidation to cyclohexadienoyl-CoA by cyclohexanoyl-CoA- and cyclohex-1-ene-1-carboxyl-CoA dehydrogenase activities

742783

physiological function

Geobacter metallireducens DSM 7210

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]