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Information on EC 1.3.7.11 - 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipid reductase

for references in articles please use BRENDA:EC1.3.7.11
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IUBMB Comments
A flavoprotein (FAD). The enzyme is involved in the biosynthesis of archaeal membrane lipids. It catalyses the reduction of all 8 double bonds in 2,3-bis-O-geranylgeranyl-sn-glycero-phospholipids and all 4 double bonds in 3-O-geranylgeranyl-sn-glycerol phospholipids with comparable activity. Unlike EC 1.3.1.101, 2,3-bis-O-geranylgeranyl-sn-glycerol 1-phosphate reductase [NAD(P)H], this enzyme shows no activity with NADPH, and requires a dedicated ferredoxin .
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The expected taxonomic range for this enzyme is: Archaea, Eukaryota
Reaction Schemes
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid
+
16
oxidized ferredoxin [iron-sulfur] cluster
=
a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid
+
16
reduced ferredoxin [iron-sulfur] cluster
+
16
Synonyms
AF0464, CrtI homologue, digeranylgeranylglycerophospholipid reductase, geranylgeranyl reductase, GGR, MA1484, MA1492, MA_1484, MA_1492, phytoene dehydrogenase family protein, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 2,3-bis-(O-phytanyl)-sn-glycero-phospholipid + 16 oxidized ferredoxin [iron-sulfur] cluster = a 2,3-bis-(O-geranylgeranyl)-sn-glycero-phospholipid + 16 reduced ferredoxin [iron-sulfur] cluster + 16 H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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