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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA
-
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA
-
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
anti-elimination of pro-2R and pro-3R hydrogens of acyl-CoA
-
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
inducible by growth on di-(2-ethylhexyl)phthalate
-
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
structural analysis of enzyme complexed with 3-ketoacyl-CoA substrate analogues
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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
acts on CoA derivatives of fatty acids with chain length from 8 to 18
-
-
-
acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
stereochemistry of the reaction
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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
stereochemistry of the reaction
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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
genetic regulation
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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
mechanism, substrate binding site, and active site structure
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acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2
in the reductive half-reaction, the substrate acyl-CoA isalpha,beta-dehydrogenated into the corresponding 2-trans-enoyl-CoA, with electrons transferred to FAD, which becomes reduced, whereas in the oxidative half-reaction reduced FAD is reoxidized by molecular oxygen, generating hydrogen peroxide
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1,16-hexadecadioyl-CoA + O2
?
-
-
-
-
?
16-hydroxy-palmitoyl-CoA + O2
?
-
-
-
-
?
2-oxoheptadecyldethio-CoA + O2
?
-
-
-
-
?
4,8,12-trimethyl-tridecanoyl-CoA + O2
?
-
-
-
-
?
4-methyl-nonanoyl-CoA + O2
?
-
-
-
-
?
6-phenyl-6-phenyl-hexanoyl-CoA + O2
?
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
acyl-CoA + O2
trans-2-enoyl-CoA + H2O2
-
assay at 25°C
-
-
ir
arachidoyl-CoA + O2
2-trans-eicosenoyl-CoA + H2O2
-
-
-
-
?
behenoyl-CoA + O2
2-trans-docosenoyl-CoA + H2O2
butyryl-CoA + O2
trans-2-butenoyl-CoA + H2O2
cis-3-decenoyl-CoA + O2
?
-
-
-
-
?
cis-3-hexenoyl-CoA + O2
?
-
best substrate for the isomerase activity of the enzyme
-
-
?
cis-3-octenoyl-CoA + O2
?
-
-
-
-
?
dec-4-cis-enoyl-CoA + O2
2-trans-4-cis-decadienoyl-CoA + H2O2
dec-4-trans-enoyl-CoA + O2
2-trans-4-trans-decadienoyl-CoA + H2O2
-
-
-
?
decanoyl-CoA + O2
trans-2,3-dehydrodecanoyl-CoA + H2O2
-
-
-
?
decanoyl-CoA + O2
trans-2-decenoyl-CoA + H2O2
dicarboxylic acid-CoAs with 6-16 carbon atoms + O2
?
-
-
-
-
?
dodecanoyl-CoA + O2
(2E)-dodec-2-enoyl-CoA + H2O2
dodecanoyl-CoA + O2
trans-dodec-2-enoyl-CoA + H2O2
-
-
-
-
r
eicosapentaenoyl-CoA + O2
?
-
-
-
-
?
furylpropionyl-CoA + O2
furylacryloyl-CoA + H2O2
-
also oxidizes aromatic/heterocyclic ring-substituted chromogenic substrates
-
?
hexadecanedioyl-CoA + O2
?
hexadecanoyl-CoA + O2
trans-2,3-dehydrohexadecanoyl-CoA + H2O2
-
-
-
?
hexanoyl-CoA + O2
(2E)-hex-2-enoyl-CoA + H2O2
indole-3-butyric acid-CoA + O2
?
-
-
-
-
?
jasmonic acid-CoA + O2
?
preferred substrate of ACX1
-
-
?
lauroyl-CoA + O2
trans-2-dodecenoyl-CoA + H2O2
leukodiacetyl-2,7-dichlorofluorescein + O2
?
-
-
-
-
?
linoleoyl-CoA + O2
2-trans-9-trans-12-trans-octadecatrienoyl-CoA + H2O2
myristoyl-CoA + O2
trans-2-tetradecenoyl-CoA + H2O2
nonanoyl-CoA + O2
trans-2-nonenoyl-CoA + H2O2
-
-
-
-
?
octadecanoyl-CoA + O2
?
preferred substrate of ACX2
-
-
?
octanoyl-CoA + O2
trans-2,3-dehydrooctanoyl-CoA + H2O2
-
-
-
?
octanoyl-CoA + O2
trans-2-octenoyl-CoA + H2O2
oleoyl-CoA + O2
2-trans-9-trans-octadecendienoyl-CoA + H2O2
palmitoyl-CoA + O2
2-trans-hexadecenoyl-CoA + H2O2
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA
palmitoyl-CoA + O2
trans-2,3-dehydropalmitoyl-CoA + H2O2
pristanoyl-CoA + O2
trans-2,3-dehydropristanoyl-CoA + H2O2
-
-
-
?
stearoyl-CoA + O2
trans-2-octadecenoyl-CoA + H2O2
trans-3-decenoyl-CoA + O2
?
-
-
-
-
?
trans-3-hexenoyl-CoA + O2
?
-
-
-
-
?
trans-3-octenoyl-CoA + O2
?
-
-
-
-
?
trihydroxycholestanoyl-CoA + O2
trans-2,3-dehydrotrihydroxycholestanoyl-CoA + H2O2
-
-
-
?
trihydroxycoprostanoyl-CoA + O2
?
-
-
-
-
?
additional information
?
-
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX1 is medium-chain specific, AtACX2 is medium- to long-chain specific
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX3 is medium-chain-specific
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
AtACX3 is medium-chain-specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
AtACX1 is medium- to long-chain specific, AtSACXis strictly short-chain specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
AtACX1 is medium- to long-chain specific, AtSACXis strictly short-chain specific
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-2 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of short-chain omega-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-3 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of (omega-1)-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
ACOX-3 serves as specialized acyl-CoA oxidase that promotes the biosynthesis of (omega-1)-ascarosides
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
specificity: C4-C20 acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
significance in metabolism of alkanes of Candida tropicalis
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
the purified recombinant CrACX2 expressed in Escherichia coli catalyzes the oxidation of fatty acyl-CoAs into trans-2-enoyl-CoA and produces H2O2
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
enzyme acts selectively on fatty acyl-CoA with 16 or 18 carbon atoms, cis-9-unsaturated esters with a C16 or C18 acyl moiety being converted with higher rate than saturated or polyunsaturated fatty acyl-CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
Cucurbita sp.
-
preference for long-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
Cucurbita sp.
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
highly specific for short-chain fatty acids
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
both isoforms ACX1.1 and 1.2 show similar broad substrate specificities
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C8-C18 acyl CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
preference for C12-C18 acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
CoA derivatives of fatty acids with chain length from 8 to 18, first reaction of peroxisomal beta-oxidation, rate limiting for this process
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
key enzyme of beta-oxidation. A basal level of long chain ACX is always present along the barley life cycle, while a higher level of expression is typical of actively growing tissues such as germinating embryos, ovary before anthesis, developing embryos, shoots and root apexes. The enzyme plays a role not only during oil reserve mobilization, but also in plant growth and metabolism
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
preference for long-chain acyl-CoA substrates
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in beta-oxidation of fatty acids in peroxisomes and glyoxysomes, respectively
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
C8-C18 acyl CoA
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
involved in lignin degradative system
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
-
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
3'-phosphate on the ribose ring and the structure of the adenine moiety are essential for substrate recognition, specificity is relatively low with respect to the structure of the pantric acid moiety
-
?
acyl-CoA + O2
trans-2,3-dehydroacyl-CoA + H2O2
-
isoform ACO-I prefers short-chain acyl-CoA substrates, isoform ACO-II prefers long-chain acyl-CoA substrates
1.3.3.6 acyl-CoA oxidase
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