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Information on EC 1.3.1.B13 - polyprenol reductase (NADPH) and Organism(s) Homo sapiens and UniProt Accession Q9H8P0

for references in articles please use BRENDA:EC1.3.1.B13
preliminary BRENDA-supplied EC number
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Homo sapiens
UNIPROT: Q9H8P0 not found.
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  • 1.3.1.B13
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The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
pprd1, pprd2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
polyprenol reductase
-
SYSTEMATIC NAME
IUBMB Comments
dolichol:NADP+ alpha-oxidoreductase
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
a dolichol + NADP+
a polyprenol + NADPH + H+
show the reaction diagram
reduction of the alpha-isoprene subunit of polyprenol
-
-
?
a polyprenol + NADPH + H+
a dolichol + NADP+
show the reaction diagram
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
a polyprenol + NADPH + H+
a dolichol + NADP+
show the reaction diagram
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PORED_HUMAN
318
6
36521
Swiss-Prot
-
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H296G
inactive mutant enzyme, shows no reduction of polyprenol
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in HEK293T cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Cantagrel, V.; Lefeber, D.J.; Ng, B.G.; Guan, Z.; Silhavy, J.L.; Bielas, S.L.; Lehle, L.; Hombauer, H.; Adamowicz, M.; Swiezewska, E.; De Brouwer, A.P.; Bluemel, P.; Sykut-Cegielska, J.; Houliston, S.; Swistun, D.; Ali, B.R.; Dobyns, W.B.; Babovic-Vuksanovic, D.; van Bokhoven, H.; Wevers, R.A.; Raetz, C.
SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder
Cell
142
203-217
2010
Homo sapiens (Q9H8P0)
Manually annotated by BRENDA team
Wheeler, P.G.; Ng, B.G.; Sanford, L.; Sutton, V.R.; Bartholomew, D.W.; Pastore, M.T.; Bamshad, M.J.; Kircher, M.; Buckingham, K.J.; Nickerson, D.A.; Shendure, J.; Freeze, H.H.
SRD5A3-CDG Expanding the phenotype of a congenital disorder of glycosylation with emphasis on adult onset features
Am. J. Med. Genet. A
170
3165-3171
2016
Homo sapiens (Q9H8P0)
Manually annotated by BRENDA team