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Enzyme Nomenclature
Information on EC 1.3.1.94 - polyprenol reductase
Word Map on EC 1.3.1.94
- 1.3.1.94
- polyprenols
- dolichols
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congenital
-
androgen
-
n-linked
- srd5a1
- testosterone
-
n-glycan
-
steroidogenic
-
psychomotor
-
alpha-dihydrotestosterone
-
coloboma
-
nystagmus
-
3hmevalonate
-
alpha-reductases
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alpha-isoprene
-
fathead
-
vitellogenin
-
anti-androgens
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double-bond
- isoprene
- akr1c3
-
hormone-refractory
-
ophthalmologic
- cyp3a7
-
polyisoprenyl
-
non-mammals
- medicine
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
1.3.1.94
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RECOMMENDED NAME
GeneOntology No.
polyprenol reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ditrans,polycis-dolichol + NADP+ = ditrans,polycis-polyprenol + NADPH + H+
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
dolichol and dolichyl phosphate biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase
The reaction occurs in the reverse direction with reduction of the terminal double bond next to the alcohol group. Isolated from human fetal brain tissue but present in all eukaryotes. In mammalian cells dolichols are predominantly 18-21 isoprene units in length.
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CAS REGISTRY NUMBER
COMMENTARY
116412-44-3
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
physiological function
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the activities of yeast cis-prenyltransferases Rer2p and Srt1p and polyprenol reductase are not co-regulated and the reductase may be the rate-limiting enzyme in dolichol synthesis if the amount of polyisoprenoids synthesized exceeds a certain level
physiological function
enzyme is necessary for the reduction of the alpha-isoprene unit of polyprenols to form dolichols, required for synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation
physiological function
Srd5a3 mutation is lethal in mouse and results in an activation of the unfolded protein response pathway
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ditrans,polycis-polyprenol + NADPH + H+
ditrans,polycis-dolichol + NADP+
-
-
-
?
ditrans,polycis-polyprenol + NADPH + H+
ditrans,polycis-dolichol + NADP+
-
-
-
?
ditrans,polycis-polyprenol + NADPH + H+
ditrans,polycis-dolichol + NADP+
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polyisoprenoids with 13-18 isoprene residues are preferentially reduced
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-
?
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expression in Saccharomyces cerevisiae and HEK-293T cells
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APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
medicine
loss of function mutations of the SRD5A3 gene cause a multisystemic syndrome with eye malformations, cerebellar vermis hypoplasia, and psychomotor delay. Plasma from patients shows increased level of polyprenoids
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LINKS TO OTHER DATABASES (specific for EC-Number 1.3.1.94)
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