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Information on EC 1.3.1.93 - very-long-chain enoyl-CoA reductase

for references in articles please use BRENDA:EC1.3.1.93

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IUBMB Comments

This is the fourth component of the elongase, a microsomal protein complex responsible for extending palmitoyl-CoA and stearoyl-CoA (and modified forms thereof) to very-long-chain acyl CoAs. cf. EC 2.3.1.199, very-long-chain 3-oxoacyl-CoA synthase, EC 1.1.1.330, very-long-chain 3-oxoacyl-CoA reductase, and EC 4.2.1.134, very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase.

The enzyme appears in viruses and cellular organisms

Synonyms
tsc13, cer10, at3g55360, very-long-chain enoyl-coa reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase), (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase), (9Z)-tricosene biosynthesis, arachidonate biosynthesis I (6-desaturase, lower eukaryotes), arachidonate biosynthesis III (6-desaturase, mammals), arachidonate biosynthesis IV (8-detaturase, lower eukaryotes), arachidonate biosynthesis V (8-detaturase, mammals), docosahexaenoate biosynthesis I (lower eukaryotes), docosahexaenoate biosynthesis III (6-desaturase, mammals), docosahexaenoate biosynthesis IV (4-desaturase, mammals), hydroxylated fatty acid biosynthesis (plants), icosapentaenoate biosynthesis I (lower eukaryotes), icosapentaenoate biosynthesis II (6-desaturase, mammals), icosapentaenoate biosynthesis III (8-desaturase, mammals), icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes), juniperonate biosynthesis, sciadonate biosynthesis, ultra-long-chain fatty acid biosynthesis, very long chain fatty acid biosynthesis I, very long chain fatty acid biosynthesis II
Highest Expressing Human Cell Lines
Cell Line Links Gene Links