Saccharomyces cerevisiae
Q06053
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IUBMB Comments A flavoenzyme. The enzyme specifically modifies uracil47
Reaction Schemes
5,6-dihydrouracil47 in tRNA
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uracil47 in tRNA
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Synonyms
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tRNA-dihydrouridine synthase 3
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5,6-dihydrouracil47 in tRNA + NAD(P)+ = uracil47 in tRNA + NAD(P)H + H+
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tRNA-5,6-dihydrouracil47:NAD(P)+ oxidoreductase
A flavoenzyme. The enzyme specifically modifies uracil47 in tRNA.
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uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil20 in tRNA + NAD(P)+
Substrates: the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr
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uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil47 in tRNA + NAD(P)+
Substrates: e.g. tRNATyr
?
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uracil47 in tRNA + NAD(P)H + H+
5,6-dihydrouracil20 in tRNA + NAD(P)+
Substrates: the enzyme specifically modifies uracil47 in tRNA, e.g. tRNATyr
?
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SwissProt
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Highest Expressing Human Cell Lines
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physiological function
formation of dihydrouridine in yeast cytoplasmic tRNAs is carried out by a family of four dihydrouridine synthases (Dus1p, Dus2p, Dus3p, and Dus4p), each acting at specific positions in tRNAs. Dus1p modifies U16 and U17, Dus2p modifies U20, Dus3p modifies U47, and Dus4p modifies U20a and U20b. These four proteins are responsible for all dihydrouridine modification of cytoplasmic tRNAs in yeast
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Xing, F.; Hiley, S.L.; Hughes, T.R.; Phizicky, E.M.
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs
J. Biol. Chem.
279
17850-17860
2004
Saccharomyces cerevisiae (Q06053), Saccharomyces cerevisiae
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