Information on EC 1.3.1.87 - 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase

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The expected taxonomic range for this enzyme is: Escherichia coli

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EC NUMBER
COMMENTARY hide
1.3.1.87
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RECOMMENDED NAME
GeneOntology No.
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate dehydrogenase
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REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+
show the reaction diagram
(2)
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3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+
show the reaction diagram
(1)
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation to 2-oxopent-4-enoate
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cinnamate and 3-hydroxycinnamate degradation to 2-oxopent-4-enoate
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3-phenylpropionate degradation
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Phenylalanine metabolism
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Microbial metabolism in diverse environments
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SYSTEMATIC NAME
IUBMB Comments
3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
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LITERATURE
(Substrate)
COMMENTARY
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LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-phenylpropionate + NAD+
3-(2,3-dihydroxyphenyl) propionate + NADH + H+
show the reaction diagram
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?
cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol + NAD+
? + NADH + H+
show the reaction diagram
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ir
cis-3-(2-carboxyethyl)-3,5-cyclohexadien-1,2-diol + NAD+
3-(2,3-dihydroxyphenyl)propionate + NADH + H+
show the reaction diagram
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ir
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
28500
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calculated from amino acid sequence
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography and Sephadex G-25M gel filtration
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3) cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
when bacteria are grown in the absence of oxygen, the expression of hcaR is decreased threefold compared to growth in aerobic conditions
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Show AA Sequence (227 entries)
Please use the Sequence Search for a specific query.
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LINKS TO OTHER DATABASES (specific for EC-Number 1.3.1.87)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)