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EC Tree
IUBMB Comments This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase, 3-phenylpropionate-2',3'-dihydrodiol dehydrogenase, 3-phenylpropionate-dihydrodiol dehydrogenase, HcaB, HCAR,
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2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase
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3-phenylpropionate-2',3'-dihydrodiol dehydrogenase
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3-phenylpropionate-dihydrodiol dehydrogenase
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HCAR
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HcaR controls expression of the neighbouring genes, hcaA1, hcaA2, hcaC, hcaB and hcaD, coding for the 3-phenylpropionate dioxygenase complex and 3-phenylpropionate-2',3'-dihydrodiol dehydrogenase
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(2E)-3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)prop-2-enoate + NAD+ = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NADH + H+
(2)
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3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD+ = 3-(2,3-dihydroxyphenyl)propanoate + NADH + H+
(1)
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3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate:NAD+ oxidoreductase
This enzyme catalyses a step in the pathway of phenylpropanoid compounds degradation.
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3-phenylpropionate + NAD+
3-(2,3-dihydroxyphenyl) propionate + NADH + H+
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cis-3-(2-carboxyethenyl)-3,5-cyclohexadiene-1,2-diol + NAD+
? + NADH + H+
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ir
cis-3-(2-carboxyethyl)-3,5-cyclohexadien-1,2-diol + NAD+
3-(2,3-dihydroxyphenyl)propionate + NADH + H+
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ir
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brenda
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28500
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calculated from amino acid sequence
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Ni-NTA column chromatography and Sephadex G-25M gel filtration
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expressed in Escherichia coli BL21(DE3) cells
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when bacteria are grown in the absence of oxygen, the expression of hcaR is decreased threefold compared to growth in aerobic conditions
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Diaz, E.; Ferrandez, A.; Garcia, J.L.
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12
J. Bacteriol.
180
2915-2923
1998
Escherichia coli
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