Reference on EC 1.3.1.72 - DELTA24-sterol reductase and Organism(s) Homo sapiens and UniProt Accession Q15392
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Filipovic, I.; Buddecke, E.
Calmodulin antagonists suppress cholesterol synthesis by inhibiting sterol DELTA24 reductase
Lipids
22
261-265
1987
Homo sapiens, Rattus norvegicus
Waterham, H.R.; Koster, J.; Romeijn, G.J.; Hennekam, R.C.M.; Vreken, P.; Andersson, H.C.; FitzPatrick, D.R.; Kelley, R.I.; Wanders, R.J.A.
Mutations in the 3beta-hydroxysterol DELTA24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis
Am. J. Hum. Genet.
69
685-694
2001
Homo sapiens
Fernandez, C.; Suarez, Y.; Ferruelo, A.J.; Gomez-Coronado, D.; Lasuncion, M.A.
Inhibition of cholesterol biosynthesis by DELTA22-unsaturated phytosterols via competitive inhibition of sterol DELTA24-reductase in mammalian cells
Biochem. J.
366
109-119
2002
Homo sapiens, Rattus norvegicus
Giera, M.; Renard, D.; Ploessl, F.; Bracher, F.
Lathosterol side chain amidesa new class of human lathosterol oxidase inhibitors
Steroids
73
299-308
2008
Homo sapiens
Kuehnle, K.; Crameri, A.; Kaelin, R.E.; Luciani, P.; Benvenuti, S.; Peri, A.; Ratti, F.; Rodolfo, M.; Kulic, L.; Heppner, F.L.; Nitsch, R.M.; Mohajeri, M.H.
Prosurvival effect of DHCR24/seladin-1 in acute and chronic responses to oxidative stress
Mol. Cell. Biol.
28
539-550
2008
Homo sapiens
Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.
Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations
Steroids
73
708-719
2008
Homo sapiens (Q15392), Homo sapiens
Nishimura, T.; Kohara, M.; Izumi, K.; Kasama, Y.; Hirata, Y.; Huang, Y.; Shuda, M.; Mukaidani, C.; Takano, T.; Tokunaga, Y.; Nuriya, H.; Satoh, M.; Saito, M.; Kai, C.; Tsukiyama-Kohara, K.
Hepatitis C virus impairs p53 via persistent overexpression of 3beta-hydroxysterol DELTA24-reductase
J. Biol. Chem.
284
36442-36452
2009
Homo sapiens
Zerenturk, E.J.; Kristiana, I.; Gill, S.; Brown, A.J.
The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)
Biochim. Biophys. Acta
1821
1269-1277
2012
Cricetulus griseus, Homo sapiens
Zerenturk, E.J.; Sharpe, L.J.; Brown, A.J.
Sterols regulate 3beta-hydroxysterol DELTA24-reductase (DHCR24) via dual sterol regulatory elements: cooperative induction of key enzymes in lipid synthesis by Sterol Regulatory Element Binding Proteins
Biochim. Biophys. Acta
1821
1350-1360
2012
Homo sapiens
Lu, X.; Li, Y.; Liu, J.; Cao, X.; Wang, X.; Wang, D.; Seo, H.; Gao, B.
The membrane topological analysis of 3beta-hydroxysteroid-DELTA24 reductase (DHCR24) on endoplasmic reticulum
J. Mol. Endocrinol.
48
1-9
2012
Homo sapiens
Yoshinari, K.; Ohno, H.; Benoki, S.; Yamazoe, Y.
Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase
Toxicol. Lett.
208
185-191
2012
Homo sapiens, Mus musculus
Zerenturk, E.J.; Sharpe, L.J.; Brown, A.J.
DHCR24 associates strongly with the endoplasmic reticulum beyond predicted membrane domains implications for the activities of this multi-functional enzyme
Biosci. Rep.
34
e00098
2014
Homo sapiens (Q15392)
Wu, B.; Chen, K.; Shrestha, S.; Ong, K.; Barter, P.; Rye, K.
High-density lipoproteins inhibit vascular endothelial inflammation by increasing 3beta-hydroxysteroid-DELTA24 reductase expression and inducing heme oxygenase-1
Circ. Res.
112
278-288
2013
Homo sapiens (Q15392)
Luu, W.; Zerenturk, E.J.; Kristiana, I.; Bucknall, M.P.; Sharpe, L.J.; Brown, A.J.
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis
J. Lipid Res.
55
410-420
2014
Homo sapiens (Q15392), Homo sapiens
Luu, W.; Hart-Smith, G.; Sharpe, L.J.; Brown, A.J.
The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally
J. Lipid Res.
56
888-897
2015
Homo sapiens (Q15392), Homo sapiens
Lu, X.; Jia, D.; Zhao, C.; Wang, W.; Liu, T.; Chen, S.; Quan, X.; Sun, D.; Gao, B.
Recombinant adenovirus-mediated overexpression of 3beta-hydroxysteroid-DELTA24 reductase
Neural Regen. Res.
9
504-512
2014
Homo sapiens (Q15392), Homo sapiens, Rattus norvegicus (Q5BQE6)
Saito, M.; Takano, T.; Nishimura, T.; Kohara, M.; Tsukiyama-Kohara, K.
3beta-hydroxysterol DELTA24-reductase on the surface of hepatitis C virus-related hepatocellular carcinoma cells can be a target for molecular targeting therapy
PLoS ONE
10
e0124197
2015
Homo sapiens (Q15392)
Lu, X.; Li, Y.; Wang, W.; Chen, S.; Liu, T.; Jia, D.; Quan, X.; Sun, D.; Chang, A.K.; Gao, B.
3 beta-hydroxysteroid-DELTA 24 reductase (DHCR24) protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum (ER) stress
PLoS ONE
9
e86753
2014
Homo sapiens (Q15392)
Zerenturk, E.J.; Sharpe, L.J.; Ikonen, E.; Brown, A.J.
Desmosterol and DHCR24 unexpected new directions for a terminal step in cholesterol synthesis
Prog. Lipid Res.
52
666-680
2013
Arabidopsis thaliana, Bombyx mori, Homo sapiens (Q15392), Homo sapiens
Kohlhaas, J.; Jaeger, M.; Lust, L.; De La Torre, C.; Hecker, M.; Korff, T.
Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression
Exp. Cell Res.
399
112446
2021
Homo sapiens
