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4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
5alpha-cholesta-7,14-dien-3beta-ol + NADPH
5alpha-cholesta-7-en-3beta-ol + NADP+
-
43% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADP+
5alpha-cholesta-8-en-3beta-ol + NADP+
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
cholesta-8,14-dien-3beta-ol + NADPH
cholesta-8-en-3beta-ol + NADP+
ergosta-8,14-dien-3beta-ol + NADPH
ergosta-8-en-3beta-ol + NADP+
-
DELTA8,14-sterol, ignosterol
-
-
?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
-
-
-
-
?
isofucosterol + NADPH
sitosterol + NADP+
additional information
?
-
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH

4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-7,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-7-en-3beta-ol + NADP+
-
64% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
C29DELTA8,14,24
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH

4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
best substrate, probably natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
presumably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+

4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+

4alpha-methylfecosterol + NADP+
-
-
-
-
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK
-
-
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
-
-
-
-
-
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH

4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADP+

5alpha-cholesta-8-en-3beta-ol + NADP+
-
LBR
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADP+
5alpha-cholesta-8-en-3beta-ol + NADP+
-
TM7SF2
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH

5alpha-cholesta-8-en-3beta-ol + NADP+
-
DELTA8,14-cholestadien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
C27DELTA8,14
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
DELTA8,14-cholestadien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
the substrate accumulates in patients suffering autosomal recessive HEM/Greenberg skeletal dysplasia
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
DELTA8,14-cholestadien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
53% activity compared with 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
-
DELTA8,14-cholestadien-3beta-ol
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+

5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
5alpha-cholesta-8,14-dien-3beta-ol + NADPH + H+
5alpha-cholesta-8-en-3beta-ol + NADP+
-
-
-
?
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH

5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
-
-
-
-
?
5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH
5alpha-ergosta-8,24(28)-dien-3beta-ol + NADP+
-
-
-
-
?
cholesta-8,14-dien-3beta-ol + NADPH

cholesta-8-en-3beta-ol + NADP+
-
-
-
-
?
cholesta-8,14-dien-3beta-ol + NADPH
cholesta-8-en-3beta-ol + NADP+
-
-
-
-
?
isofucosterol + NADPH

sitosterol + NADP+
-
-
-
-
-
isofucosterol + NADPH
sitosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1
-
-
-
additional information

?
-
-
brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
-
additional information
?
-
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
-
additional information
?
-
-
C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis
-
-
-
additional information
?
-
-
role of LBR in the cholesterol biosynthesis pathway is unclear
-
-
-
additional information
?
-
enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
-
-
-
additional information
?
-
-
enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
-
-
-
additional information
?
-
enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
-
-
-
additional information
?
-
-
enzyme MaSR1 can reduce the double bond of a cholesterol biosynthetic intermediate analogously to the human enzyme
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
-
the charge and geometry given via residues E233, R235, D289, K351, R458, and R461 is important for enzyme activity
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
reduction of 14-double bond of conjugated DELTA8,14-diene sterols and DELTA7,14-diene sterols
-
-
-
additional information
?
-
-
sterol substrate specificity study
-
-
-
additional information
?
-
-
anaerobic conditions yield maximal rates of reduction
-
-
-
additional information
?
-
-
4-nor-methyldiene sterols, 5alpha-cholesta-8,14-dien-3beta-ol, and 5alpha-cholesta-7,14-dien-3beta-ol are reduced at about 50% of the rate of the corresponding 4-gem-dimethyldiene sterols, for both the C27-sterol and C29-sterol, the higher reaction rate of the 8,14-diene system is consistently observed over the isomeric 7,14-diene
-
-
-
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
-
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
-
additional information
?
-
-
reduction of 14-double bond of sterol-conjugated dienes
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
microsomal enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
-
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
-
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme is involved in de novo synthesis of progesterone from lanosterol via cholesterol, pathway overview
-
-
-
additional information
?
-
-
substrate specificity
-
-
-
additional information
?
-
-
enzyme acts on a range of steroids with a 14(15)-double bond
-
-
-
additional information
?
-
-
DELTA8,14 derivatives are the only substrates to be transformed under normal biosynthetic conditions
-
-
-
additional information
?
-
-
no activity with 5alpha-cholesta-7,14-dien-3beta-ol, 7,14-cholestadien-3beta-ol or 5alpha-cholest-14-en-3beta-ol, 14-cholesten-3beta-ol
-
-
-
additional information
?
-
-
important roles of 4alpha-methyl group and side-chain substitution for recognition but not for catalysis, presence of DELTA8(9) unsaturation is compulsory for catalysis
-
-
-
additional information
?
-
-
enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
presumably the natural substrate
-
-
?
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + NADPH + H+
4alpha-methylfecosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by enzyme FK
-
-
-
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
5alpha-cholesta-8,14-dien-3beta-ol + NADPH
5alpha-cholesta-8-en-3beta-ol + NADP+
O76062, Q14739
the substrate accumulates in patients suffering autosomal recessive HEM/Greenberg skeletal dysplasia
-
-
?
follicular fluid meiosis-activating sterol + NADPH
testicular meiosis-activating sterol + NADP+
-
-
-
-
?
isofucosterol + NADPH
sitosterol + NADP+
-
step in the biosynthesis of the brassicasterol phytohormones, catalyzed by bifunctinal enzyme DIM1/CBB1/DWF1
-
-
-
additional information
?
-
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
-
probably the natural substrate
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
G4SW86
-
-
-
?
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+
G4SW86
-
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH

4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
4alpha-methyl-8,14,24(28)-ergostatrien-3beta-ol + NADPH
4alpha-methyl-8,24(28)-ergostadien-3beta-ol + NADP+
-
4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol
-
-
?
additional information

?
-
-
brassicasterols have regulatory function in the plants concerning growth and development, the enzyme is up-regulated by several growth-promoting hormones including brassinolide and auxin, overview
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
-
enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
O76062
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
-
additional information
?
-
Q14739
enzyme-deficiency causes the lethal autosomal recessive HEM/Greenberg skeletal dysplasia, characterized by short limbs, fetal hydrops, abnormal chondro-osseous calcification
-
-
-
additional information
?
-
-
C14SR is encoded by the TM7SF2 gene. TM7SF2 but not LBR, gene expression is regulated by cell sterol levels in HepG2 (human) and H-35 (rat) hepatoma cells. Primary role of C14SR in human cholesterol biosynthesis
-
-
-
additional information
?
-
-
role of LBR in the cholesterol biosynthesis pathway is unclear
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis
-
-
-
additional information
?
-
-
enzyme plays a key role in sterol biosynthesis, sterol content in vivo
-
-
-
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
-
additional information
?
-
-
catalyzes anaerobically NADPH-dependent reduction of 14-double bond of 8,14-diene or 7,14-diene sterols that are sterol intermediates formed during C-32 demethylation in cholesterol biosynthesis from lanosterol in mammals
-
-
-
additional information
?
-
-
reduction of 14-double bond of sterol-conjugated dienes
-
-
-
additional information
?
-
-
14-reductase has a important regulatory role in the overall cholesterol synthetic pathway
-
-
-
additional information
?
-
-
microsomal enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
important essential enzyme of cholesterol biosynthesis from lanosterol
-
-
-
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
-
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
reduction of DELTA8,14-intermediate in ergosterol biosynthetic pathway to DELTA8-intermediate occurs by the trans addition of two hydrogens to the 14alpha- and 15beta-positions
-
-
-
additional information
?
-
-
enzyme of biosynthetic pathways of ergosterol, major sterol in yeast, and cholesterol including a DELTA8,14-sterol intermediate as result of demethylation of lanosterol at C-14
-
-
-
additional information
?
-
-
essential enzyme of ergosterol, yeast sterol, biosynthesis from lanosterol
-
-
-
additional information
?
-
-
enzyme is involved in de novo synthesis of progesterone from lanosterol via cholesterol, pathway overview
-
-
-
additional information
?
-
-
DELTA8,14 derivatives are the only substrates to be transformed under normal biosynthetic conditions
-
-
-
additional information
?
-
-
enzyme involved in sterol, phytosterol, biosynthesis, DELTA8,14-sterols are intermediates in the biosynthesis of higher plant sterols, phytosterols
-
-
-
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15-aza-24-methylene-D-homocholestadiene-3beta-ol
2-amino-nonyl-6-methoxyl-tetralin muriate
-
-
25-hydroxy-cholesterol
-
IC50: 0.45 mM
3beta-(2-(diethylamino)ethoxy)androst-5-en-17-one
-
U18666A, IC50: 0.004 mM
4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
-
using a genetic aproach in Saccharomyces cerevisiae it is shown that ERG24 is the target enzyme of compound 4-(3-[[1-(4-bromophenyl)piperidin-4-yl](methyl)amino]-1-methoxypropyl)benzonitrile
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
A25822B
-
competitive inhibitor
AY9944-A-7
-
enzyme-specific inhibitor, leads to apoptosis in vivo at high concentrations in cumulus cells of oocytes
brefeldin
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cerulenin
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cholesterol
-
enzyme suppressed by feeding 5% cholesterol, 70% decrease in enzyme activity
clotrimazole
-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
Detergents
-
enzyme solubilization by detergents: inactivation
fluconazole
-
inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
fluphenazine
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
HgCl2
-
3 mM: more than 99% inhibition, inhibition negligible in the presence of 10 mM glutathione
itraconazole
-
inhibition of growth of wild-type and mutant strain NJ25, only slightly of mutant strains NJ50, NJ51, and NJ55, overview
ketoconazole
-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
miconazole
-
IC50: 0.15 mM
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
N-alkyl morpholine derivatives
-
fungicides
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
N-ethylmaleimide
-
5 mM: 53% inhibition, inhibition negligible in the presence of 10 mM glutathione
N-substituted 8-azadecalins
-
potent inhibitors
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
NADP+
-
in the absence of NADPH-regenerating system, Ki: 0.45 mM; no inhibition by NAD+
Nystatin
-
inhibition of growth of wild-type and mutant strain NJ25, not of mutants strains NJ50, NJ51, and NJ55, overview
Phospholipase A2
-
very high inhibition by very small concentrations, activity not restored by addition of phospholipids or any components presumed to be released from treated microsomes. Various concentration ranges of potential cofactors including FMN, FAD, AMP, ADP, ATP, coenzyme Q, Coenzyme A, and hemin, plus heat-treated microsomes, and lipid extracts of microsomes does not restore microsomal 14-reductase of phospholipase A2-treated microsomes
-
sulfhydryl-binding agents
-
-
-
terbinafine
-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
Triparanol
-
4-chloro-alpha-[4-[2-diethylaminoethoxy]phenyl]-alpha-(4-methylphenyl)benze-methanol, slight inhibition
Tris-HCl
-
Tris-HCl buffer, 28% inhibition, not restored by addition of KCl at various concentrations
Tween 80
-
concentrations of Tween 80 higher than 1.5 g/l: inhibitory effect
15-aza-24-methylene-D-homocholestadiene-3beta-ol

-
A25822B, extremely potent inhibitor
15-aza-24-methylene-D-homocholestadiene-3beta-ol
-
A25822B, extremely potent inhibitor
15-azasterol

-
antimycotic agent, IC50: 0.00003 mM
15-azasterol
-
15-aza-24-methylene-D-homocholestadiene; potent antimycotic agent, designated A258223, non-competitively inhibition at very low concentrations, Ki: 0.000002 mM
15-azasterol
-
antimycotic agent, IC50: 0.00003 mM
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol

-
extremely potent inhibitor
8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
extremely potent inhibitor
Ca2+

-
slight inhibition of growth of the wild-type strain, increased inhibition of growth of erg24 mutant strains
Ca2+
-
4 mM: very slight, 3.5% inhibition
cyanide

-
no inhibition
cyanide
-
cyanide ion, membrane-bound enzyme, modest inhibition at high concentrations, greater than 1 mM, partial purified enzyme, sodium cyanide, no or very poor inhibition, 10 mM: 3.5% inhibition
cycloheximide

-
inhibition of growth of mutant strains NJ25, NJ50, NJ51, and NJ55, not of wild-type strain and mutant NJ25, overview
cycloheximide
-
the 2.5fold increase in enzymic activity due to the diurnal rhythm is completely abolished by cycloheximide
fenpropidin

-
-
fenpropidin
-
fungicide, very potent inhibitor; IC50: 0.0018 mM; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-piperidine
fenpropidin
-
fungicide, very potent inhibitor; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-piperidine
fenpropidin
-
good inhibitor, IC50: 0.003 mM
fenpropimorph

-
impairs cell expansion and affects gene expression in vivo, the effects cannot be reversed by addition of exogenous brassicasterols, changes sterol composition, phenotype is similar to fk-mutant plants, molecular mechanism
fenpropimorph
-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
fenpropimorph
-
fungicide, very potent inhibitor; IC50: 0.0023 mM; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine
fenpropimorph
-
fungicide, very potent inhibitor; N-[3-(p-tert-butylphenyl)-2-methylpropyl]-cis-2,6-dimethylmorpholine
fenpropimorph
-
very good inhibitor, IC50: 0.0008 mM
Mg2+

-
4 mM: slight, 6% inhibition
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol

-
extremely potent inhibitor
N(1,5,9-trimethyldecyl)-4alpha,10-dimethyl-8-aza-trans-decal-3beta-ol
-
extremely potent inhibitor
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol

-
strong inhibition
-
N-alkyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
strong inhibition
-
N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol

-
extremely potent inhibitor
N-Benzyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
extremely potent inhibitor
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol

-
extremely potent inhibitor
-
N-dodecyl-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
extremely potent inhibitor
-
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol

-
extremely potent inhibitor
-
N-[(3)-4-tert-butylphenyl-(2-methyl)propyl]-8-aza-4alpha,10-dimethyl-trans-decal-3beta-ol
-
extremely potent inhibitor
-
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride

-
AY-9944, strong inhibition, 0.0003 mM: 50% inhibition, 0.0005 mM: 65% inhibition
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
-
0.01% AY-9944: suppression and inhibition; AY-9944, competitive inhibitor, strong inhibition, Ki: 0.00026; AY-9944, direct inhibitory effects of sterol 14-reductase; hepatocyte, IC50: 0.00025 mM, microsomes, IC50: 0.0003 mM
trans-1,4-bis(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride
-
AY 9944, very slight inhibition, IC50: 0.04 mM
tridemorph

-
inhibition of growth of wild-type and mutant strains NJ25, NJ50, NJ51, and NJ55, overview
tridemorph
-
2,6-dimethyl-N-tridecylmorpholine; fungicide; slight inhibitor, IC50: 0.098 mM
tridemorph
-
2,6-dimethyl-N-tridecylmorpholine; fungicide
tridemorph
-
slight inhibition, IC50: 0.025
additional information

-
inhibition by a series of ammonium-ion-containing fungicides
-
additional information
-
no direct inhibition by 3beta-hydroxy-4,4-dimethyl-5alpha-cholest-8(14)-en-15-one, even when concentration is increased to level of Km for substrate; no inhibition by trypsin
-
additional information
-
kinetic pattern of inhibition; no inhibition by lovastatin, mevalonolactone, Squalestatin 1, (E)-N-ethyl-N-(6,6-dimethyl-2-hepten-4-ynyl)-3-((3,3'-bithiophen-5-yl)methoxy)benzenemethanamine, NB-598
-
additional information
-
no inhibition by ergosterol, up to 0.2 mM
-
additional information
-
inhibition by a series of ammonium-ion-containing fungicides; no inhibition by 4alpha,10-dimethyl-trans-decal-3beta-ol; no inhibition by menadione or 10 mM NAD+
-
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D363A
site-directed mutagenesis, inactive mutant
I151M
site-directed mutagenesis, inactive mutant
K406A
site-directed mutagenesis, inactive mutant
L304M
site-directed mutagenesis, inactive mutant
N359A
site-directed mutagenesis, inactive mutant
R395A
site-directed mutagenesis, inactive mutant
W352A
site-directed mutagenesis, inactive mutant
Y241F
site-directed mutagenesis, inactive mutant
Y360A
site-directed mutagenesis, inactive mutant
Y407A
site-directed mutagenesis, inactive mutant
Y414A
site-directed mutagenesis, inactive mutant
D363A
-
site-directed mutagenesis, inactive mutant
-
N359A
-
site-directed mutagenesis, inactive mutant
-
W352A
-
site-directed mutagenesis, inactive mutant
-
Y407A
-
site-directed mutagenesis, inactive mutant
-
Y414A
-
site-directed mutagenesis, inactive mutant
-
D207N
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
D227N
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
D276N
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
D289E
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
D289N
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
D293N
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
D394N
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
D462N
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
D463N
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
E22Q
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
E233D
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
E233Q
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
E475Q
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
G225C
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
H388A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
H457A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
K229A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
K351A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
K351R
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
K469A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
R212A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
R217A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
R235A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
R235K
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
R345A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
R355A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
R458A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
R458K
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
R461A
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
R461K
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
T371A
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y124F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y273F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y317F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y391F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y445F
-
site-directed mutagenesis, mutant cannot complement enzyme-deficient erg-3 mutant strain mat a
Y447F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y470F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y477F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
Y490F
-
site-directed mutagenesis, mutant can complement enzyme-deficient erg-3 mutant strain mat a
additional information

-
mutational blockage of the enzyme leads to accumulation of atypical products from substrate 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol in vivo, i.e. 5alpha-cholesta-8,14-dien-3beta-ol, (24R)-5alpha-ergosta-8,14-dien-3beta-ol, and (24R)-5alpha-stigmasta-8,14-dien-3beta-ol
additional information
-
erg24 gene disruption mutant strains, i.e. strain NJ25, NJ50, NJ51, and NJ55, show growth, but altered phenotypes, e.g. increased sensitivity against an allylamine antifungal compound, overview
additional information
enzyme deficiency due to mutations in the lamin B receptor gene causes autosomal recessive HEM/Greenberg skeletal dysplasia
additional information
enzyme deficiency due to mutations in the lamin B receptor gene causes autosomal recessive HEM/Greenberg skeletal dysplasia
additional information
generation of gene Tm7sf2 knockout mice
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Acute Kidney Injury
The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
Adenoma
Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.
Alzheimer Disease
Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts.
Breast Neoplasms
The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer.
Candidiasis
ERG2 and ERG24 Are Required for Normal Vacuolar Physiology as Well as Candida albicans Pathogenicity in a Murine Model of Disseminated but Not Vaginal Candidiasis.
Carcinoma
Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.
Chondrodysplasia Punctata
Genetic disorders of cholesterol biosynthesis in mice and humans.
delta14-sterol reductase deficiency
Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3 beta-hydroxysterol delta 14-reductase deficiency due to mutations in the lamin B receptor gene.
delta14-sterol reductase deficiency
HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency.
delta14-sterol reductase deficiency
Impaired cell proliferation in regenerating liver of 3 ?-hydroxysterol ?14-reductase (TM7SF2) knock-out mice.
Herpes Simplex
A three-residue signal confers localization of a reporter protein in the inner nuclear membrane.
Herpes Simplex
Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection.
Ichthyosis
HEM dysplasia and ichthyosis are likely laminopathies and not due to 3beta-hydroxysterol Delta14-reductase deficiency.
Ichthyosis
Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly.
Infection
Fate of the inner nuclear membrane protein lamin B receptor and nuclear lamins in herpes simplex virus type 1 infection.
Leukemia
Antinuclear antibodies as ancillary markers in primary biliary cirrhosis.
Leukemia
Molecular diagnostics of primary biliary cirrhosis.
Liver Cirrhosis, Biliary
Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR.
Liver Cirrhosis, Biliary
Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis.
Metabolism, Inborn Errors
Genetic disorders of cholesterol biosynthesis in mice and humans.
Mevalonate Kinase Deficiency
Genetic disorders of cholesterol biosynthesis in mice and humans.
Neoplasms
Candidate diagnostic markers and tumor suppressor genes for adrenocortical carcinoma by expression profile of genes on chromosome 11q13.
Neoplasms
Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas.
Neoplasms
Loss of lamin B receptor is necessary to induce cellular senescence.
Papilloma
The loss of Tm7sf gene accelerates skin papilloma formation in mice.
Pelger-Huet Anomaly
Alterations in nuclear structure promote lupus autoimmunity in a mouse model.
Pelger-Huet Anomaly
Mouse neutrophils lacking lamin B-receptor expression exhibit aberrant development and lack critical functional responses.
Pelger-Huet Anomaly
Mutations at the mouse ichthyosis locus are within the lamin B receptor gene: a single gene model for human Pelger-Huët anomaly.
Renal Insufficiency
The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury.
Scleroderma, Systemic
LMNA, ZMPSTE24, and LBR are not mutated in scleroderma.
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Bottema, C.K.; Parks, L.W.
DELTA14-Sterol reductase in Saccharomyces cerevisiae
Biochim. Biophys. Acta
531
301-307
1978
Saccharomyces cerevisiae, Saccharomyces cerevisiae 3701B
brenda
Paik, Y.K.; Trzaskos, J.M.; Shafiee, A.; Gaylor, J.L.
Microsomal enzymes of cholesterol biosynthesis from lanosterol. Characterization, solubilization, and partial purification of NADPH-dependent DELTA8,14-steroid 14-reductase
J. Biol. Chem.
259
13413-13423
1984
Rattus norvegicus
brenda
Kim, C.K.; Jeon, K.I.; Lim, D.M.; Johng, T.N.; Trzaskos, J.M.; Gaylor, J.L.; Paik, Y.K.
Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase
Biochim. Biophys. Acta
1259
39-48
1995
Rattus norvegicus
brenda
Roberti, R.; Bennati, A.M.; Galli, G.; Caruso, D.; Maras, B.; Aisa, C.; Beccari, T.; Della Fazia, M.A.; Servillo, G.
Cloning and expression of sterol DELTA14-reductase from bovine liver
Eur. J. Biochem.
269
283-290
2002
Bos taurus, Homo sapiens
brenda
Taton, M.; Benveniste, P.; Rahier, A.
Microsomal DELTA8,14-sterol DELTA14-reductase in higher plants. Characterization and inhibition by analogues of a presumptive carbocationic intermediate of the reduction reaction
Eur. J. Biochem.
185
605-614
1989
Embryophyta, Zea mays
brenda
Lorenz, R.T.; Parks, L.W.
Cloning, sequencing, and disruption of the gene encoding sterol C-14 reductase in Saccharomyces cerevisiae
DNA Cell Biol.
11
685-692
1992
Saccharomyces cerevisiae
brenda
Baloch, R.I.; Mercer, E.I.
Inhibition of sterol DELTA8 -> DELTA7-isomerase and DELTA14-reductase by fenpropimorph, tridemorph and fenpropidin in cell-free enzyme systems from Saccharomyces cerevisiae
Phytochemistry
26
663-668
1987
Saccharomyces cerevisiae, Saccharomyces cerevisiae NCYC 739, Ustilago maydis
-
brenda
Waterham, H.R.; Koster, J.; Mooyer, P.; Noort Gv, G.; Kelley, R.I.; Wilcox, W.R.; Wanders, R.J.; Hennekam, R.C.; Oosterwijk, J.C.
Autosomal recessive HEM/Greenberg skeletal dysplasia is caused by 3beta-hydroxysterol DELTA14-reductase deficiency due to mutations in the lamin B receptor gene
Am. J. Hum. Genet.
72
1013-1017
2003
Homo sapiens, Homo sapiens (O76062), Homo sapiens (Q14739)
brenda
Jia, N.; Arthington-Skaggs, B.; Lee, W.; Pierson, C.A.; Lees, N.D.; Eckstein, J.; Barbuch, R.; Bard, M.
Candida albicans sterol C-14 reductase, encoded by the ERG24 gene, as a potential antifungal target site
Antimicrob. Agents Chemother.
46
947-957
2002
Candida albicans
brenda
Yamashita, Y.; Nishibori, M.; Terada, T.; Isobe, N.; Shimada, M.
Gonadotropin-induced DELTA14-reductase and DELTA7-reductase gene expression in cumulus cells during meiotic resumption of porcine oocytes
Endocrinology
146
186-194
2005
Sus scrofa
brenda
Prakash, A.; Kasbekar, D.P.
Genes encoding chimeras of Neurospora crassa erg-3 and human TM7SF2 proteins fail to complement Neurospora and yeast sterol C-14 reductase mutants
J. Biosci.
27
105-112
2002
Homo sapiens, Neurospora crassa
brenda
Prakash, A.; Kasbekar, D.P.
The sterol C-14 reductase encoded by the Neurospora crassa erg-3 gene: essential charged and polar residues identified by site-specific mutagenesis
Mol. Genet. Genomics
266
787-795
2002
Neurospora crassa
brenda
He, J.X.; Fujioka, S.; Li, T.C.; Kang, S.G.; Seto, H.; Takatsuto, S.; Yoshida, S.; Jang, J.C.
Sterols regulate development and gene expression in Arabidopsis
Plant Physiol.
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