Information on EC 1.3.1.40 - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

for references in articles please use BRENDA:EC1.3.1.40
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:


The expected taxonomic range for this enzyme is: Pseudomonas cruciviae

top print hide
EC NUMBER
COMMENTARY hide
1.3.1.40
-
top print hide
RECOMMENDED NAME
GeneOntology No.
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,6-dioxo-6-phenylhexanoate + NADP+ = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+
show the reaction diagram
-
-
-
-
top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
top print hide
SYSTEMATIC NAME
IUBMB Comments
2,6-dioxo-6-phenylhexanoate:NADP+ DELTA2-oxidoreductase
Broad specificity; reduces a number of compounds produced by Pseudomonas from aromatic hydrocarbons by ring fission.
top
top print hide
CAS REGISTRY NUMBER
COMMENTARY hide
104645-83-2
-
top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate + NADPH
2,6-dioxo-6-phenylhexanoate + NADP+
show the reaction diagram
2-methoxy-6-oxo-6-phenylhexa-2,3-dienoic acid methyl ester + NADPH
2-methoxy-6-oxo-6-phenylhexa-2-enoic acid methyl ester + NADP+
show the reaction diagram
-
enzymes I and II
-
?
2-methoxy-6-oxo-6-phenylhexa-2,4-dienoic acid methyl ester + NADPH
2-methoxy-6-oxo-6-phenylhexa-2-enoic acid methyl ester + NADP+
show the reaction diagram
ring fission product of 3-methoxycatechol + NADPH
?
show the reaction diagram
-
enzymes I and II
-
-
?
ring fission products from 3-isopropylcatechol + NADPH
?
show the reaction diagram
-
enzymes I, II and III
-
-
?
ring fission products from 3-methylcatechol + NADPH
?
show the reaction diagram
-
enzymes I, II and III
-
-
?
ring fission products from biphenyl-2,3-diol + NADPH
?
show the reaction diagram
-
enzymes I, II and III
-
-
?
ring fission products of catechol + NADPH
?
show the reaction diagram
-
enzymes I and II
-
-
?
top print hide
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
top print hide
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
monoiodoacetate
-
-
p-chloromercuribenzoate
-
-
top print hide
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.013
-
activity of reducing enzyme III in cells grown on glucose
0.049
-
activity of reducing enzyme III in cells grown on biphenyl
2.5
-
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
top print hide
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6
-
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
top print hide
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
top print hide
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
170000
top print hide
pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5 - 7
-
-
390769
top print hide
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, dialyzate
-
top print hide
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-6-oxo-phenylhexa-2,4-dienoate reducing enzyme III
-
top
top
LINKS TO OTHER DATABASES (specific for EC-Number 1.3.1.40)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)