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Information on EC 1.3.1.34 - 2,4-dienoyl-CoA reductase [(2E)-enoyl-CoA-producing]

for references in articles please use BRENDA:EC1.3.1.34

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IUBMB Comments

This bacterial enzyme catalyses the reduction of either (2E,4E)-2,4-dienoyl-CoA or (2E,4Z)-2,4-dienoyl-CoA to (2E)-2-enoyl-CoA. The enzyme from Escherichia coli contains FAD, FMN, and an [4Fe-4S] iron sulfur cluster. cf. EC 1.3.1.124, 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing].

The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
  • 1.3.1.34
  • beta-oxidation
  • unsaturated
  • polyunsaturated
  • odd-numbered
  • even-numbered
  • 3-hydroxyacyl-coa
  • 5.3.3.8
  • chain-shortened
  • trans-2
  • tetradecylthioacetic
  • reductase-dependent
  • petroselinic
  • delta3-delta2-enoyl-coa
  • omega-oxidation
  • 3,delta

Synonyms
2,4-dienoyl-coa reductase, 2,4-dienoyl coenzyme a reductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2E)-2-enoyl-CoA + NADP+ = a (2E,4E)-2,4-dienoyl-CoA + NADPH + H+
show the reaction diagram
a (2E)-2-enoyl-CoA + NADP+ = a (2E,4Z)-2,4-dienoyl-CoA + NADPH + H+
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links