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Information on EC 1.3.1.3 - DELTA4-3-oxosteroid 5beta-reductase

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IUBMB Comments
The enzyme from human efficiently catalyses the reduction of progesterone, androstenedione, 17alpha-hydroxyprogesterone and testosterone to 5beta-reduced metabolites; it can also act on aldosterone, corticosterone and cortisol, but to a lesser extent . The bile acid intermediates 7alpha,12alpha-dihydroxy-4-cholesten-3-one and 7alpha-hydroxy-4-cholesten-3-one can also act as substrates .
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The enzyme appears in viruses and cellular organisms
Synonyms
akr1d1, 5beta-por, h5beta-red, progesterone 5beta-reductase, p5betar, steroid 5beta-reductase, aldo-keto reductase 1d1, 3-oxo-delta4-steroid 5beta-reductase, 5-beta-reductase, delta4-hydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
17,21-dihydroxy-5beta-pregnane-3,11,20-trione + NADP+ = cortisone + NADPH + H+
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5beta-cholestan-3-one + NADP+ = cholest-4-en-3-one + NADPH + H+
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