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Alkalosis
The effects of acidosis and alkalosis on long bone vascular resistance.
Alzheimer Disease
Biliverdin reductase as a target in drug research and development: Facts and hypotheses.
Alzheimer Disease
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment.
Alzheimer Disease
Biliverdin Reductase-A correlates with inducible nitric oxide synthasein in atorvastatin treated aged canine brain.
Alzheimer Disease
Biliverdin reductase-A impairment links brain insulin resistance with increased A? production in an animal model of aging: Implications for Alzheimer disease.
Alzheimer Disease
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.
Alzheimer Disease
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease.
Alzheimer Disease
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
Alzheimer Disease
Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease.
Alzheimer Disease
Oxidative and nitrosative modifications of biliverdin reductase-a in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
Anemia
Bone marrow: its contribution to heme catabolism.
Anemia, Hemolytic
Bone marrow: its contribution to heme catabolism.
Anemia, Iron-Deficiency
Bone marrow: its contribution to heme catabolism.
Anemia, Sickle Cell
Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.
Anemia, Sickle Cell
Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease.
Anemia, Sideroblastic
Bone marrow: its contribution to heme catabolism.
Aneurysm
Recurring Thalamic Symptoms Due to Intracranial Dural Arteriovenous Fistula: Report of Unusual Case and Treatment Outcome.
Aortic Aneurysm, Abdominal
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
Atherosclerosis
Biliverdin reductase as a target in drug research and development: Facts and hypotheses.
Atherosclerosis
Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease.
Atherosclerosis
Plaque fissure: the link between atherosclerosis and thrombosis.
Atrial Fibrillation
Direct oral anticoagulants in patients with atrial fibrillation and bioprosthetic valve replacement: A meta-analysis.
Atrioventricular Block
Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs.
biliverdin reductase deficiency
Biliverdin reductase deficiency triggers an endothelial-to-mesenchymal transition in human endothelial cells.
biliverdin reductase deficiency
Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins.
biliverdin reductase deficiency
BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration.
Bradycardia
Proarrhythmic electrical remodelling is associated with increased beat-to-beat variability of repolarisation.
Brain Injuries
Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.
Brain Neoplasms
Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase.
Breast Neoplasms
Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer.
Breast Neoplasms
Human biliverdin reductase regulates the molecular mechanism underlying cancer development.
Carcinoma
The heme oxygenase/biliverdin reductase system in skin cancers.
Carcinoma
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity.
Carcinoma, Basal Cell
The heme oxygenase/biliverdin reductase system in skin cancers.
Carcinoma, Hepatocellular
MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-?B pathway to suppress cell growth in hepatocellular carcinoma cells.
Carcinoma, Renal Cell
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity.
Cardiotoxicity
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters {beta}-adrenergic receptor ligand-mediated cardiac dysfunction.
Cerebral Hemorrhage
[Dural arteriovenous fistula involving the cavernous sinus as the cause of intracerebral venous hemorrhage: a case report]
Chickenpox
Varicella breakthrough infection and effectiveness of 2-dose varicella vaccine in China.
Cholestasis
A homozygous nonsense mutation (c.214C->A) in the biliverdin reductase alpha gene (BLVRA) results in accumulation of biliverdin during episodes of cholestasis.
Cholestasis
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy.
Colorectal Neoplasms
Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/?-Catenin Signaling Pathway.
Coma
Cerebrovascular carbon dioxide reactivity assessed by intracranial pressure dynamics in severely head injured patients.
Death, Sudden, Cardiac
Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs.
Diabetes Mellitus, Type 2
Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control.
Drug-Related Side Effects and Adverse Reactions
Torsadogenic Drug-induced Increased Short-term Variability of JT-area.
Encephalomyelitis
Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis.
Endocardial Fibroelastosis
Fetal Echocardiography in Predicting Postnatal Outcome in Borderline Left Ventricle.
Essential Hypertension
Association of a BLVRA Common Polymorphism with Essential Hypertension and Blood Pressure in Kazaks.
Fatty Liver
Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity.
Fatty Liver
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Glioblastoma
Biliverdin reductase plays a crucial role in hypoxia-induced chemoresistance in human glioblastoma.
Heart Diseases
Biliverdin reductase as a target in drug research and development: Facts and hypotheses.
Heart Septal Defects, Ventricular
Biventricular repair after Norwood palliation.
Heart Septal Defects, Ventricular
Staged Biventricular Repair-Oriented Strategy in Borderline Biventricular Repair Candidates with Ventricular Septal Defect.
Hepatitis
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt.
Hyperemia
Different effects of beta-1-adrenergic blocking agents with ISA or without ISA on peripheral blood flow.
Hyperemia
Extensive basal ganglia edema caused by a traumatic carotid-cavernous fistula: a rare presentation related to a basal vein of Rosenthal anatomical variation.
Hyperglycemia
A critical and comprehensive insight on heme oxygenase and related products including carbon monoxide, bilirubin, biliverdin and ferritin in type-1 and type-2 diabetes.
Hypertension
Extensive basal ganglia edema caused by a traumatic carotid-cavernous fistula: a rare presentation related to a basal vein of Rosenthal anatomical variation.
Infarction, Middle Cerebral Artery
Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion.
Infarction, Middle Cerebral Artery
Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.
Infections
Serial ultrasound assessment of the basal vein of Rosenthal in HSV encephalitis.
Infections
Studies on heme and heme oxygenase during Plasmodium berghei infection in golden hamsters.
Insulin Resistance
Biliverdin reductase-A impairment links brain insulin resistance with increased A? production in an animal model of aging: Implications for Alzheimer disease.
Insulin Resistance
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.
Insulin Resistance
Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
Insulin Resistance
Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target.
Insulin Resistance
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Jaundice, Neonatal
Computational and experimental studies on the catalytic mechanism of biliverdin-IXbeta reductase.
Jaundice, Neonatal
The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXalpha reductase and human biliverdin-IXbeta reductase.
Leukemia
Targeting biliverdin reductase overcomes multidrug resistance in leukemia HL60 cells.
Liver Cirrhosis
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice).
Liver Diseases
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice).
Liver Diseases
Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity.
Liver Diseases
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Liver Neoplasms
Predictive role BLVRA mRNA expression in hepatocellular cancer.
Melanoma
The heme oxygenase/biliverdin reductase system in skin cancers.
Meningioma
Encountering a basal vein of Rosenthal variant during the anterior transpetrosal approach.
Metabolic Syndrome
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Multiple Sclerosis
Biliverdin reductase, a major physiologic cytoprotectant, suppresses experimental autoimmune encephalomyelitis.
Myocardial Infarction
Microvolt t-wave alternans and beat-to-beat variability of repolarization during early post-ischemic remodeling in a pig heart.
Neoplasms
Biliverdin Reductase A (BLVRA) Promotes Colorectal Cancer Cell Progression by Activating the Wnt/?-Catenin Signaling Pathway.
Neoplasms
Biliverdin reductase as a target in drug research and development: Facts and hypotheses.
Neoplasms
Biliverdin reductase-A protein levels are reduced in type 2 diabetes and are associated with poor glycometabolic control.
Neoplasms
Biliverdin reductase: a target for cancer therapy?
Neoplasms
Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer.
Neoplasms
Human biliverdin reductase regulates the molecular mechanism underlying cancer development.
Neoplasms
Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.
Neoplasms
Overexpression of biliverdin reductase enhances resistance to chemotherapeutics.
Neoplasms
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity.
Nephritis
Heme catabolism in human kidneys. Effect of various nephritides.
Neuroblastoma
Biliverdin reductase as a target in drug research and development: Facts and hypotheses.
Neurodegenerative Diseases
BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration.
Neurodegenerative Diseases
Oxidative and nitrosative modifications of biliverdin reductase-a in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment.
Neutropenia
A Three-Arm Randomized Phase II Study of Bendamustine/Rituximab with Bortezomib Induction or Lenalidomide Continuation in Untreated Follicular Lymphoma: ECOG-ACRIN E2408.
Nevus, Pigmented
The heme oxygenase/biliverdin reductase system in skin cancers.
Non-alcoholic Fatty Liver Disease
CRISPR Cas9-mediated deletion of biliverdin reductase A (BVRA) in mouse liver cells induces oxidative stress and lipid accumulation.
Non-alcoholic Fatty Liver Disease
Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity.
Obesity
Reduced Biliverdin Reductase-A Expression in Visceral Adipose Tissue is Associated with Adipocyte Dysfunction and NAFLD in Human Obesity.
Obesity
Reduced biliverdin reductase-A levels are associated with early alterations of insulin signaling in obesity.
Persistent Infection
Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis.
Pneumothorax
Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha.
Pulmonary Atresia
Biventricular Repair of Pulmonary Atresia After Fontan Palliation.
Renal Insufficiency
Low serum bilirubin in chronic renal failure. Relation to haem metabolism.
Sagittal Sinus Thrombosis
Venous transcranial Doppler in acute dural sinus thrombosis.
Sepsis
SEP-8: UPREGULATION OF BVR ACTIVITIES IN WHITE BLOOD CELLS OF PATIENTS WITH SIRS AND SEPSIS.
Skin Neoplasms
The heme oxygenase/biliverdin reductase system in skin cancers.
Stroke
Argatroban Increased the Basal Vein Drainage and Improved Outcomes in Acute Paraventricular Ischemic Stroke Patients.
Stroke
Direct oral anticoagulants in patients with atrial fibrillation and bioprosthetic valve replacement: A meta-analysis.
Stroke
Preserved cognition and functional independence after a large right posterior cerebral artery infarct: longitudinal clinical and neuropathological findings.
Subarachnoid Hemorrhage
Subarachnoid Hemorrhage Increases Level of Heme Oxygenase-1 and Biliverdin Reductase in the Choroid Plexus.
Tachycardia, Ventricular
Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs.
Torsades de Pointes
Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs.
Tuberculosis
Rv2074 is a novel F420 H2 -dependent biliverdin reductase in Mycobacterium tuberculosis.
Tuberculosis
The molecular structure of Rv2074, a probable pyridoxine 5'-phosphate oxidase from Mycobacterium tuberculosis, at 1.6 angstroms resolution.
Varicose Veins
Dural Arteriovenous Fistula of the Sinus of the Lesser Sphenoid Wing Presenting with Pontine Hemorrhage.
Vascular Diseases
Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.
Ventricular Fibrillation
Motor Cortex and Hippocampus Display Decreased Heme Oxygenase Activity 2 Weeks After Ventricular Fibrillation Cardiac Arrest in Rats.
Ventricular Fibrillation
Selective chemical ablation of transient receptor potential vanilloid 1 expressing neurons in the left stellate ganglion protects against ischemia-induced ventricular arrhythmias in dogs.
Virus Diseases
Rapamycin inhibition of baculovirus recombinant (BVr) ribosomal protein S6 kinase 1 (S6K1) is mediated by an event other than phosphorylation.
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metabolism
-
BVR is part of the heme oxygenase protection system, overview
metabolism
-
HIF-1alpha regulates the expression of BVR and other enzymes involved in oxidative stress response in lung macrophages, overview
metabolism
-
the heme oxygenase/biliverdin reductase axis is the main metabolic pathway for heme degradation. Activation during stress results in increased heme degradation and acceleration of biliverdin transformation to bilirubin
metabolism
-
it is shown that the rates of sHO-1 (shortened form of heme oxygenase-1) metabolism in the presence and absence of BVR are equal
metabolism
isoform BVRA interacts with components in both the PI3-kinase/Akt and the IRK/IRS/PI3-kinase/MAPK pathyway
metabolism
the enzyme is a coactivator of Akt1 and a key mediator of the Akt1/glycogen synthase kinase 3 pathway
metabolism
the enzyme catalyzes the reduction of heme-derived biliverdin into bilirubin, which is a powerful endogenous free radical scavenger
physiological function
biliverdin reductase converts biliverdin to bilirubin. Additionally, acting as a transcription factor and possessing a capacity of a serine/threonine kinase, it may modulate signaling pathways. BVR exhibits cytoprotection, important role of PKCa/b kinase in BVR-mediated improvement in cell survival
physiological function
-
BV reductase regulates cell growth and apoptosis, its knockdown increases apoptosis. The BVR also phosphorylates the insulin receptor substrate 1, IRS-1, on serine residues preventing its phosphorylation by insulin receptor, which represent a physiological mechanism for increasing glucose uptake. And BVR is a nuclear transporter of ERK1/2 with metabolic regulatory role
physiological function
-
BVR is required for heme degradation. BVR plays a role in bile pigment metabolism, in cell protection, and in signal transduction, detailed overview. BVR reverses the inhibitory effect of biliverdin on PKC enzymes
physiological function
-
coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival, a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction
physiological function
-
primary spontaneous pneumothorax, PSP, in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin. Cigarette smoke is a risk factor of recurrence of the disease, overview
physiological function
-
the significant effect of biliverdin on decrease in extracellular oxidative stress in BVR-deficient cells may be related to direct scavenging of extracellular reactive oxygen and nitrogen species by biliverdin
physiological function
-
BLVRA may be among the most effective physiological reactive oxygen species scavenging systems and may play an important role in regulating cellular senescence
physiological function
-
H2O2 markedly induces BLVRA activity in young human diploid fibroblasts, but not in senescent human diploid fibroblasts(HDF). Depletion of BLVRA reduces the H2O2-dependent induction of heme oxygenase-1 (HO-1) in young human diploid fibroblasts, but not in senescent cells. Lentiviral RNAi transfected stable primary HDFs with reduced BLVRA expression show upregulation of the CDK inhibitor family members p16, p53, and p21, followed by cell cycle arrest in G0-G1 phase with high expression of senescence-associated beta-galactosidase
physiological function
-
hBVR suppresses Goodpasture antigen-binding protein autophosphorylation in a concentration-dependent manner. The inhibitory effect of hBVR on GPBP kinase activity extended to its ability to phosphorylate its substrate, GPA-derived peptide
physiological function
-
TNF-alpha alpha-NF-kappaB-dependent expression of Goodpasture antigen-binding protein is regulated by biliverdin reductase
physiological function
-
the cytoprotective role of the enzyme may be permissive for cancer/tumor growth. The enzyme plays a role in transporting kinases to the membrane and nucleus and can also transport heme within the cell. The enzyme suppresses the activity of Goodpasture antigen-binding protein and hence limits the exposure of the epitope of Goodpasture antigen, thus limiting autoimmunity
physiological function
the enzyme protects against glucose intolerance and diabetes by affecting the pancreatic islet. Isoform BVRA enhances protein kinase CbetaII localization at the cellular membrane and also modulates protein kinase Cdelta and protein kinase Czeta
physiological function
the enzyme is involved in the pathogenesis of neurodegenerative, metabolic, cardiovascular and immune-inflammatory diseases as well as in cancer
physiological function
the enzyme regulates the molecular mechanism underlying cancer development
additional information
-
bilirubin is a superior antioxidant in isolated mitochondria and neutrophils as compared to biliverdin, overview. XO-derived superoxide is decreased in a concentration-dependent fashion by bilirubin whereas biliverdin has no inhibitory effect and even significantly increases the signal pointing towards pro-oxidative effects
additional information
-
bilirubin is an important component of cellular defense mechanisms with cytoprotective features
additional information
-
isoproterenol, ISO, stimulation of BVR levels enhances the stability of heme oxygenase 2, HO-2. Interaction between HO-2 and BVR is a survival factor for cardiomyocytes during ISO stimulation
additional information
-
pharmacodynamics of the heme oxygenase/biliverdin reductase system, overview
additional information
the BVR activity and expression is not affected by MAP kinase inhibitors, overview
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Singleton, J.W.; Laster, L.
Biliverdin reductase of guinea pig liver
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1965
Cavia porcellus, Homo sapiens
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Salim, M.; Brown-Kipphut, B.A.; Maines, M.D.
Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation
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2001
Homo sapiens
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Cunningham, O.; Dunne, A.; Sabido, P.; Lightner, D.; Mantle, T.J.
Studies on the specificity of the tetrapyrrole substrate for human biliverdin-IXalpha reductase and biliverdin-IXbeta reductase. Structure-activity relationships define models for both active sites
J. Biol. Chem.
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2000
Homo sapiens
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Ahmad, Z.; Salim, M.; Maines, M.D.
Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress
J. Biol. Chem.
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9226-9232
2002
Homo sapiens
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Maines, M.D.; Trakshel, G.M.
Purification and characterization of human biliverdin reductase
Arch. Biochem. Biophys.
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1993
Homo sapiens, Rattus norvegicus
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Maines, M.D.; Mayer, R.D.; Erturk, E.; Huang, T.J.; Disantagnese, A.
The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma - pH and cofactor-specific increase in activity
J. Urol.
162
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1999
Homo sapiens
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Colpaert, E.E.; Timmermans, J.P.; Lefebvre, R.A.
Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 in human and pig gastric fundus
Free Radic. Biol. Med.
32
630-637
2002
Homo sapiens, Sus scrofa
brenda
Kravets, A.; Hu, Z.; Miralem, T.; Torno, M.D.; Maines, M.D.
Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
J. Biol. Chem.
279
19916-19923
2004
Homo sapiens
brenda
Miralem, T.; Hu, Z.; Torno, M.D.; Lelli, K.M.; Maines, M.D.
siRNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells
J. Biol. Chem.
280
17084-17092
2005
Homo sapiens
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Baranano, D.E.; Rao, M.; Ferris, C.D.; Snyder, S.H.
Biliverdin reductase: a major physiologic cytoprotectant
Proc. Natl. Acad. Sci. USA
99
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2002
Homo sapiens
brenda
Lerner-Marmarosh, N.; Shen, J.; Torno, M.D.; Kravets, A.; Hu, Z.; Maines, M.D.
Human biliverdin reductase: A member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity
Proc. Natl. Acad. Sci. USA
102
7109-7114
2005
Homo sapiens
brenda
Maines, M.D.; Miralem, T.; Lerner-Marmarosh, N.; Shen, J.; Gibbs, P.E.
Human biliverdin reductase - a previously unknown activator of protein kinase C beta II
J. Biol. Chem.
282
8110-8122
2007
Homo sapiens
brenda
Maines, M.D.
New insights into biliverdin reductase functions: linking heme metabolism to cell signaling
Physiology
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382-389
2005
Arabidopsis sp., Canis lupus familiaris, Cavia porcellus, Gallus gallus, Cyanidium caldarium, Homo sapiens, Mus musculus, Pan troglodytes, Rattus norvegicus, Sus scrofa, Takifugu rubripes, Xenopus sp.
brenda
Maines, M.D.
Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways
Antioxid. Redox Signal.
9
2187-2195
2007
Homo sapiens
brenda
Tudor, C.; Lerner-Marmarosh, N.; Engelborghs, Y.; Gibbs, P.E.; Maines, M.D.
Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin
Biochem. J.
413
405-416
2008
Homo sapiens
brenda
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase
FASEB J.
21
3949-3962
2007
Homo sapiens
brenda
Gibbs, P.E.; Maines, M.D.
Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase
Int. J. Cancer
121
2567-2574
2007
Homo sapiens
brenda
Wu, B.; Liu, X.; Shen, J.
Old biliverdin reductase: links to insulin resistance and may be a novel therapeutic target
Med. Hypotheses
71
73-76
2008
Homo sapiens
brenda
Florczyk, U.M.; Jozkowicz, A.; Dulak, J.
Biliverdin reductase: new features of an old enzyme and its potential therapeutic significance
Pharmacol. Rep.
60
38-48
2008
Rattus norvegicus, Rattus norvegicus (P46844), Homo sapiens (P30043), Homo sapiens (P53004)
brenda
Lerner-Marmarosh, N.; Miralem, T.; Gibbs, P.E.; Maines, M.D.
Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling
Proc. Natl. Acad. Sci. USA
105
6870-6875
2008
Homo sapiens
brenda
Wegiel, B.; Baty, C.J.; Gallo, D.; Csizmadia, E.; Scott, J.R.; Akhavan, A.; Chin, B.Y.; Kaczmarek, E.; Alam, J.; Bach, F.H.; Zuckerbraun, B.S.; Otterbein, L.E.
Cell surface biliverdin reductase mediates biliverdin-induced anti-inflammatory effects via phosphatidylinositol 3-kinase and Akt
J. Biol. Chem.
284
21369-21378
2009
Homo sapiens, Mus musculus
brenda
Maghzal, G.J.; Leck, M.C.; Collinson, E.; Li, C.; Stocker, R.
Limited role for the bilirubin-biliverdin redox amplification cycle in the cellular antioxidant protection by biliverdin reductase
J. Biol. Chem.
284
29251-29259
2009
Homo sapiens
brenda
Gafvels, M.; Holmstroem, P.; Somell, A.; Sjoevall, F.; Svensson, J.O.; Stahle, L.; Broome, U.; Stal, P.
A novel mutation in the biliverdin reductase-A gene combined with liver cirrhosis results in hyperbiliverdinaemia (green jaundice)
Liver Int.
29
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2009
Homo sapiens
brenda
Perez, M.J.; Castano, B.; Jimenez, S.; Serrano, M.A.; Gonzalez-Buitrago, J.M.; Marin, J.J.
Role of vitamin C transporters and biliverdin reductase in the dual pro-oxidant and anti-oxidant effect of biliary compounds on the placental-fetal unit in cholestasis during pregnancy
Toxicol. Appl. Pharmacol.
232
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2008
Rattus norvegicus, Homo sapiens (P53004), Homo sapiens
brenda
Kapitulnik, J.; Maines, M.D.
Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin
Trends Pharmacol. Sci.
30
129-137
2009
Homo sapiens
brenda
Florczyk, U.; Golda, S.; Zieba, A.; Cisowski, J.; Jozkowicz, A.; Dulak, J.
Overexpression of biliverdin reductase enhances resistance to chemotherapeutics
Cancer Lett.
300
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2010
Homo sapiens (P53004)
brenda
Mancuso, C.; Barone, E.
The heme oxygenase/biliverdin reductase pathway in drug research and development
Curr. Drug Metab.
10
579-594
2009
Homo sapiens, Rattus norvegicus
brenda
Maines, M.D.
Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings
Curr. Drug Targets
11
1586-1594
2010
Homo sapiens
brenda
Ding, B.; Gibbs, P.E.; Brookes, P.S.; Maines, M.D.
The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters beta-adrenergic receptor ligand-mediated cardiac dysfunction
FASEB J.
25
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2010
Homo sapiens, Rattus norvegicus
brenda
Jansen, T.; Hortmann, M.; Oelze, M.; Opitz, B.; Steven, S.; Schell, R.; Knorr, M.; Karbach, S.; Schuhmacher, S.; Wenzel, P.; Muenzel, T.; Daiber, A.
Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin
J. Mol. Cell. Cardiol.
49
186-195
2010
Homo sapiens
brenda
Goven, D.; Boutten, A.; Lecon-Malas, V.; Marchal-Somme, J.; Soler, P.; Boczkowski, J.; Bonay, M.
Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha
PLoS ONE
5
e10886
2010
Homo sapiens
brenda
Barone, E.; Di Domenico, F.; Cenini, G.; Sultana, R.; Cini, C.; Preziosi, P.; Perluigi, M.; Mancuso, C.; Butterfield, D.A.
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment
Biochim. Biophys. Acta
1812
480-487
2011
Homo sapiens
brenda
Reed, J.R.; Huber, W.J.; Backes, W.L.
Human heme oxygenase-1 efficiently catabolizes heme in the absence of biliverdin reductase
Drug Metab. Dispos.
38
2060-2066
2010
Homo sapiens
brenda
Kim, S.Y.; Kang, H.T.; Choi, H.R.; Park, S.C.
Biliverdin reductase A in the prevention of cellular senescence against oxidative stress
Exp. Mol. Med.
43
15-23
2011
Homo sapiens
brenda
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB
FASEB J.
24
3239-3254
2010
Homo sapiens
brenda
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Tudor, C.; Hagen, F.K.; Maines, M.D.
The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C
J. Biol. Chem.
287
24698-24712
2012
Homo sapiens
brenda
Fu, G.; Liu, H.; Doerksen, R.J.
Molecular modeling to provide insight into the substrate binding and catalytic mechanism of human biliverdin-IXalpha reductase
J. Phys. Chem. B
116
9580-9594
2012
Homo sapiens
brenda
Franklin, E.; Mantle, T.; Dunne, A.
Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway
Biochim. Biophys. Acta
1834
2573-2578
2013
Homo sapiens (P53004)
brenda
Huan, L.; Bao, C.; Chen, D.; Li, Y.; Lian, J.; Ding, J.; Huang, S.; Liang, L.; He, X.
MicroRNA-127-5p targets the biliverdin reductase B/nuclear factor-kappaB pathway to suppress cell growth in hepatocellular carcinoma cells
Cancer Sci.
107
258-266
2016
Homo sapiens
brenda
Lee, S.J.; Kang, H.K.; Eum, W.S.; Park, J.; Choi, S.Y.; Kwon, H.Y.
Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress
Cell Biol. Int.
41
514-524
2017
Homo sapiens (P53004), Homo sapiens
brenda
Chu, W.T.; Nesbitt, N.M.; Gnatenko, D.V.; Li, Z.; Zhang, B.; Seeliger, M.A.; Browne, S.; Mantle, T.J.; Bahou, W.F.; Wang, J.
Enzymatic activity and thermodynamic stability of biliverdin IXbeta reductase are maintained by an active site serine
Chemistry
23
1891-1900
2017
Homo sapiens (P30043), Homo sapiens
brenda
Zhang, M.; Song, S.; Yi, Z.; Zhao, X.; Fu, L.; Wang, L.; Ma, C.; Mao, M.; Xing, Y.; Zhu, D.
Human biliverdin reductase promotes EMT through the ERK1/2 signal pathway in breast cancer
Eur. J. Pharmacol.
788
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2016
Homo sapiens
brenda
Miralem, T.; Lerner-Marmarosh, N.; Gibbs, P.E.; Jenkins, J.L.; Heimiller, C.; Maines, M.D.
Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation
FASEB J.
30
2926-2944
2016
Homo sapiens (P53004), Homo sapiens
brenda
Gibbs, P.E.; Miralem, T.; Maines, M.D.
Biliverdin reductase: a target for cancer therapy?
Front. Pharmacol.
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119
2015
Homo sapiens
brenda
Spencer, A.L.; Bagai, I.; Becker, D.F.; Zuiderweg, E.R.; Ragsdale, S.W.
Protein/protein interactions in the mammalian heme degradation pathway: heme oxygenase-2, cytochrome P450 reductase, and biliverdin reductase
J. Biol. Chem.
289
29836-29858
2014
Homo sapiens
brenda
Pallua, J.D.; Schaefer, G.; Seifarth, C.; Becker, M.; Meding, S.; Rauser, S.; Walch, A.; Handler, M.; Netzer, M.; Popovscaia, M.; Osl, M.; Baumgartner, C.; Lindner, H.; Kremser, L.; Sarg, B.; Bartsch, G.; Huck, C.W.; Bonn, G.K.; Klocker, H.
MALDI-MS tissue imaging identification of biliverdin reductase B overexpression in prostate cancer
J. Proteomics
91
500-514
2013
Homo sapiens (P30043)
brenda
Takao, H.; Hirabayashi, K.; Nishigaya, Y.; Kouriki, H.; Nakaniwa, T.; Hagiwara, Y.; Harada, J.; Sato, H.; Yamazaki, T.; Sakakibara, Y.; Suiko, M.; Asada, Y.; Takahashi, Y.; Yamamoto, K.; Fukuyama, K.; Sugishima, M.; Wada, K.
A substrate-bound structure of cyanobacterial biliverdin reductase identifies stacked substrates as critical for activity
Nat. Commun.
8
14397
2017
Rattus norvegicus (P06762), Homo sapiens (P53004), Synechocystis sp. PCC 6803 (P72782)
brenda
Subhanova, I.; Muchova, L.; Lenicek, M.; Vreman, H.J.; Luksan, O.; Kubickova, K.; Kreidlova, M.; Zima, T.; Vitek, L.; Urbanek, P.
Expression of biliverdin reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients
PLoS ONE
8
e57555
2013
Homo sapiens (P53004), Homo sapiens
brenda
O'Brien, L.; Hosick, P.A.; John, K.; Stec, D.E.; Hinds, T.D.
Biliverdin reductase isozymes in metabolism
Trends Endocrinol. Metab.
26
212-220
2015
Homo sapiens (P30043), Homo sapiens (P53004)
brenda
Mancuso, C.
Biliverdin reductase as a target in drug research and development Facts and hypotheses
Free Radic. Biol. Med.
172
521-529
2021
Homo sapiens (P53004), Homo sapiens
brenda
Zhang, M.; Xin, W.; Yi, Z.; Li, Y.; Liu, Y.; Zhang, H.; Chen, H.; Chen, X.; Tan, S.; Zhu, D.
Human biliverdin reductase regulates the molecular mechanism underlying cancer development
J. Cell. Biochem.
119
1337-1345
2018
Homo sapiens (P53004), Homo sapiens
brenda