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Information on EC 1.3.1.21 - 7-dehydrocholesterol reductase and Organism(s) Bombyx mori and UniProt Accession Q1JUZ2

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IUBMB Comments
The enzyme is part of the cholesterol biosynthesis pathway.
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This record set is specific for:
Bombyx mori
UNIPROT: Q1JUZ2
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The taxonomic range for the selected organisms is: Bombyx mori
The enzyme appears in selected viruses and cellular organisms
Synonyms
dhcr7, 7-dehydrocholesterol reductase, neverland, daf-36, sterol delta7-reductase, 7-dhc reductase, 3beta-hydroxysterol delta7-reductase, 7-dhcr, 3beta-hydroxysterol-delta7-reductase, 7-dehydrocholesterol delta7-reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Neverland
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7-DHC reductase
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Dwarf5 protein
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reductase, 7-dehydrocholesterol
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-
-
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Sterol delta-7-reductase
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
redox reaction
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-
-
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oxidation
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-
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reduction
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PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
cholesterol:NADP+ DELTA7-oxidoreductase
The enzyme is part of the cholesterol biosynthesis pathway.
CAS REGISTRY NUMBER
COMMENTARY hide
9080-21-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
cholesterol + O2 + NAD(P)H + H+
cholesta-5,7-dien-3beta-ol + NAD(P)+ + 2 H2O
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
wild-type Bombyx mori enzyme rescues the lethality of Drosophila melanogaster animals treated with RNAi against the nvd gene, whereas Bombyx mori mutants H190A and H282A do not
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
NVD_BOMMO
453
1
50950
Swiss-Prot
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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H190A
mutation within Rieske [2Fe-2S]-motif, complete loss of activity
H282A
mutation within non-heme Fe(II) binding motif, complete loss of activity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression in S2 cell
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Yoshiyama-Yanagawa, T.; Enya, S.; Shimada-Niwa, Y.; Yaguchi, S.; Haramoto, Y.; Matsuya, T.; Shiomi, K.; Sasakura, Y.; Takahashi, S.; Asashima, M.; Kataoka, H.; Niwa, R.
The conserved Rieske oxygenase DAF-36/Neverland is a novel cholesterol-metabolizing enzyme
J. Biol. Chem.
286
25756-25762
2011
Bombyx mori (Q1JUZ2), Caenorhabditis elegans (Q17938)
Manually annotated by BRENDA team