Information on EC 1.3.1.15 - dihydroorotate dehydrogenase (NADP+)

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IUBMB Comments
Binds FMN and FAD . Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NAD+ (EC 1.3.1.14) as electron acceptor. The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor .
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The enzyme appears in viruses and cellular organisms
Synonyms
reductase, orotate (reduced nicotinamide adenine dinucleotide phosphate), triphosphopyridine-linked dihydroorotic dehydrogenase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-dihydroorotate + NADP+ = orotate + NADPH + H+
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