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Information on EC 1.3.1.126 - 2-epi-5-epi-valiolone dehydrogenase
for references in articles please use BRENDA:EC1.3.1.126
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EC Tree 1 Oxidoreductases
1.3 Acting on the CH-CH group of donors
1.3.1 With NAD+ or NADP+ as acceptor
1.3.1.126 2-epi-5-epi-valiolone dehydrogenase
IUBMB Comments
The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase.
The enzyme appears in viruses and cellular organisms
showSynonyms
gadusol synthase, MT-Ox, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
gadusol synthase
MT-Ox
gadusol synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-epi-5-epi-valiolone + NAD+ = demethylgadusol + NADH + H+
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SYSTEMATIC NAME
IUBMB Comments
2-epi-5-epi-valiolone:NAD+ 2,3-oxidoreductase
The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
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2-epi-5-epi-valiolone + NAD+
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2-epi-5-epi-valiolone + NAD+
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2-epi-5-epi-valiolone + NAD+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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2-epi-5-epi-valiolone + NAD+
demethylgadusol + NADH + H+
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). E7EXW6_DANRE
470
0
52764
TrEMBL
other Location (Reliability: 3)
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Osborn, A.R.; Almabruk, K.H.; Holzwarth, G.; Asamizu, S.; LaDu, J.; Kean, K.M.; Karplus, P.A.; Tanguay, R.L.; Bakalinsky, A.T.; Mahmud, T.
De novo synthesis of a sunscreen compound in vertebrates
eLife
4
e05919
2015
Alligator mississippiensis, Anas platyrhynchos, Anolis carolinensis, Astyanax mexicanus, Aureococcus anophagefferens, Chelonia mydas, Chrysemys picta bellii, Coccomyxa subellipsoidea, Columba livia, Danio rerio (E7EXW6), Falco cherrug, Ficedula albicollis, Gallus gallus, Geospiza fortis, Maylandia zebra, Meleagris gallopavo, Melopsittacus undulatus, Neolamprologus brichardi, no activity in Acropora digitifera, no activity in Balaenoptera acutorostrata scammoni, no activity in Bos taurus, no activity in Branchiostoma floridae, no activity in Callithrix jacchus, no activity in Capra hircus, no activity in Ceratotherium simum simum, no activity in Chinchilla lanigera, no activity in Chlorocebus sabaeus, no activity in Ciona intestinalis, no activity in Cricetulus griseus, no activity in Eptesicus fuscus, no activity in Equus caballus, no activity in Erinaceus europaeus, no activity in Felis catus, no activity in Gorilla gorilla, no activity in Heterocephalus glaber, no activity in Homo sapiens, no activity in Hydra vulgaris, no activity in Latimeria chalumnae, no activity in Lipotes vexillifer, no activity in Macaca fascicularis, no activity in Mesocricetus auratus, no activity in Monodelphis domestica, no activity in Mus musculus, no activity in Mustela putorius furo, no activity in Myotis davidii, no activity in Myotis lucifugus, no activity in Nematostella vectensis, no activity in Nomascus leucogenys, no activity in Takifugu rubripes, no activity in Tetraodon nigroviridis, no activity in Vicugna pacos, Oncorhynchus mykiss, Oreochromis niloticus, Oryzias latipes, Pelodiscus sinensis, Poecilia formosa, Pseudopodoces humilis, Pundamilia nyererei, Salmo salar, Taeniopygia guttata, Xenopus tropicalis, Xiphophorus maculatus, Zonotrichia albicollis, Dicentrarchus labrax, Fundulus heteroclitus, Gasterosteus aculeatus, Lepisosteus oculatus, no activity in Odobenus rosmarus divergens, no activity in Orcinus orca, no activity in Ornithorhynchus anatinus, no activity in Orycteropus afer, no activity in Otolemur garnettii, no activity in Ovis aries, no activity in Pan troglodytes, no activity in Papio anubis, no activity in Peromyscus maniculatus bairdii, no activity in Pteropus alecto, no activity in Rattus norvegicus, no activity in Sarcophilus harrisii, no activity in Trichechus manatus latirostris
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