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Information on EC 1.3.1.109 - butanoyl-CoA dehydrogenase complex (NAD+, ferredoxin)

for references in articles please use BRENDA:EC1.3.1.109

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IUBMB Comments

The enzyme is a complex of a flavin-containing dehydrogenase component (Bcd) and an electron-transfer flavoprotein dimer (EtfAB). The enzyme complex, isolated from the bacteria Acidaminococcus fermentans and butanoate-producing Clostridia species, couples the exergonic reduction of (E)-but-2-enoyl-CoA to butanoyl-CoA by NADH to the endergonic reduction of ferredoxin by NADH, using electron bifurcation to overcome the steep energy barrier in ferredoxin reduction.

The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
2
+
2
reduced ferredoxin [iron-sulfur] cluster
=
+
2
+
2
oxidized ferredoxin [iron-sulfur] cluster

Synonyms
bcd/etfab, etfab/bcd, bifurcating butyryl-coa dehydrogenase, bcd/electron-transfer flavoprotein complex, electron transferring flavoprotein/butyryl-coa dehydrogenase, butyryl-coa dehydrogenase/electron transferring flavoprotein complex, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
butanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (E)-but-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -
Highest Expressing Human Cell Lines
Cell Line Links Gene Links