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Information on EC 1.23.1.2 - (+)-lariciresinol reductase and Organism(s) Linum album and UniProt Accession Q4R0I0

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IUBMB Comments
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) , Linum perenne (perennial flax) and Linum corymbulosum .
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This record set is specific for:
Linum album
UNIPROT: Q4R0I0
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The taxonomic range for the selected organisms is: Linum album
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
(+)-lariciresinol reductase, (+)-pinoresinol-(+)-lariciresinol reductase, (+)-pinoresinol/(+)-lariciresinol reductase, bi-functional pinoresinol/lariciresinol reductase, bifunctional pinoresinol-lariciresinol reductase 2, LuPLR2, More, pinoresinol reductase, pinoresinol reductase 2, pinoresinol-lariciresinol reductase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
pinoresinol-lariciresinol reductase
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SYSTEMATIC NAME
IUBMB Comments
(–)-secoisolariciresinol:NADP+ oxidoreductase
The reaction is catalysed in vivo in the opposite direction to that shown. A multifunctional enzyme that also reduces (+)-pinoresinol [EC 1.23.1.1, (+)-pinoresinol reductase]. Isolated from the plants Forsythia intermedia [1,2], Thuja plicata (western red cedar) [3], Linum perenne (perennial flax) [5] and Linum corymbulosum [6].
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-lariciresinol + NADPH + H+
(-)-secoisolariciresinol + NADP+
show the reaction diagram
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-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
PILR1_LINAL
326
0
36379
Swiss-Prot
other Location (Reliability: 2)
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
Ni-NTA column chromatography
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21(DE3)pLysS cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
von Heimendahl, C.B.; Schaefer, K.M.; Eklund, P.; Sjoeholm, R.; Schmidt, T.J.; Fuss, E.
Pinoresinol-lariciresinol reductases with different stereospecificity from Linum album and Linum usitatissimum
Phytochemistry
66
1254-1263
2005
Linum album (Q4R0I0)
Manually annotated by BRENDA team