Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Abnormalities, Multiple
Modeling the nonthyroidal illness syndrome.
Abortion, Habitual
Iodothyronine deiodinase 2 (DiO2) regulates trophoblast cell line cycle, invasion and apoptosis; and its downregulation is associated with early recurrent miscarriage.
Abscess
Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.
Acute Lung Injury
Erratum: Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Acute Lung Injury
Role of type 2 deiodinase in response to acute lung injury (ALI) in mice.
Acute Lung Injury
Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Adenocarcinoma, Follicular
Retinoids stimulate type I iodothyronine 5'-deiodinase activity in human follicular thyroid carcinoma cell lines.
Adenoma
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Adenoma
Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules.
Atherosclerosis
Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.
Bacterial Infections
Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection.
Blindness
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice.
Bone Resorption
[Osteoporosis treatment in patients with hyperthyroidism]
Brain Injuries, Traumatic
Up-regulation of type 2 iodothyronine deiodinase mRNA in reactive astrocytes following traumatic brain injury in the rat.
Brain Ischemia
Induction of type 2 iodothyronine deiodinase in astrocytes after transient focal cerebral ischemia in the rat.
Brain Ischemia
Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury.
Brain Neoplasms
Common genetic variations of deiodinase genes and prognosis of brain tumor patients.
Brain Neoplasms
Expression of type II iodothyronine deiodinase in brain tumors.
Breast Neoplasms
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.
Breast Neoplasms
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
Breast Neoplasms
Thyroid hormones and selenium status in breast cancer.
Carcinogenesis
Activated Thyroid Hormone Promotes Differentiation and Chemotherapeutic Sensitization of Colorectal Cancer Stem Cells by Regulating Wnt and BMP4 Signaling.
Carcinogenesis
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
Carcinogenesis
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Carcinoma
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
Carcinoma
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
Carcinoma
Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels.
Carcinoma
The deiodination of thyroxine to triiodothyronine in the testes of patients with prostate cancer.
Carcinoma
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
Carcinoma
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Carcinoma
Type I 5'-iodothyronine deiodinase activity and mRNA are remarkably reduced in renal clear cell carcinoma.
Carcinoma, Basal Cell
The Sonic Hedgehog-induced Type 3 Deiodinase Facilitates Tumorigenesis of Basal Cell Carcinoma by Reducing Gli2-inactivation.
Carcinoma, Hepatocellular
Increases in phenolic and nonphenolic ring deiodinase activity due to serum in monolayer liver cell cultures.
Carcinoma, Hepatocellular
The relationship between deiodinase activity and inflammatory responses under the stimulation of uremic toxins.
Carcinoma, Papillary
Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma.
Carcinoma, Renal Cell
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
Carcinoma, Squamous Cell
The NANOG Transcription Factor Induces Type 2 Deiodinase Expression and Regulates the Intracellular Activation of Thyroid Hormone in Keratinocyte Carcinomas.
Cardiomegaly
Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure.
Cardiomyopathies
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Cardiomyopathy, Dilated
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Cardiomyopathy, Dilated
Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy.
Cardiomyopathy, Restrictive
Absence of Myocardial Thyroid Hormone Inactivating Deiodinase Results in Restrictive Cardiomyopathy in Mice.
Choriocarcinoma
Functional characterisation of the CRE/TATA box unit of type 2 deiodinase gene promoter in a human choriocarcinoma cell line.
Colonic Neoplasms
?-Catenin Regulates Deiodinase Levels and Thyroid Hormone Signaling in Colon Cancer Cells.
Coronary Occlusion
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Cystic Fibrosis
Hepatic iodothyronine deiodinase type 1 activity is decreased in two DeltaF508 cystic fibrosis mouse models.
Deafness
Deletion of the thyroid hormone-activating type 2 deiodinase rescues cone photoreceptor degeneration but not deafness in mice lacking type 3 deiodinase.
Diabetes Mellitus
Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish.
Diabetes Mellitus
Association of Type II 5' Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients.
Diabetes Mellitus
Effect of streptozotocin-induced diabetes mellitus on type 1 deiodinase (D1) in inherited D1-deficient mice.
Diabetes Mellitus
Effect of triiodothyronine administration on reduced expression of type 1 iodothyronine deiodinase messenger ribonucleic acid in streptozotocin-induced diabetic rats.
Diabetes Mellitus
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Diabetes Mellitus
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
Diabetes Mellitus
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Diabetes Mellitus
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Diabetes Mellitus
Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Age-dependent changes in glucose homeostasis in male deiodinase type 2 knockout zebrafish.
Diabetes Mellitus, Type 2
Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis.
Diabetes Mellitus, Type 2
Association of Type II 5' Monodeiodinase Thr92Ala Single Nucleotide Gene Polymorphism and Circulating Thyroid Hormones Among Type 2 Diabetes Mellitus Patients.
Diabetes Mellitus, Type 2
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
Diabetes Mellitus, Type 2
The diabetes medication canagliflozin promotes mitochondrial remodelling of adipocyte via the AMPK-Sirt1-Pgc-1? signalling pathway.
Diabetes Mellitus, Type 2
The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.
Diabetes Mellitus, Type 2
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Diabetes Mellitus, Type 2
Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus.
Diabetes, Gestational
High levels of maternal total tri-iodothyronine, and low levels of fetal free L-thyroxine and total tri-iodothyronine, are associated with altered deiodinase expression and activity in placenta with gestational diabetes mellitus.
Diabetes, Gestational
Peripheral deiodinase activity: A potential explanation for the association between maternal weight and gestational hyperglycemia.
Encephalomyelitis
Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Inflammation severely alters thyroid hormone signaling in the central nervous system during experimental allergic encephalomyelitis in rat: Direct impact on OPCs differentiation failure.
Encephalomyelitis, Autoimmune, Experimental
Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis.
Endometriosis
Identification of genes with differential regulation in primate endometrium during the proliferative and secretory phases of the cycle.
Euthyroid Sick Syndromes
Differential involvement of nuclear factor-{kappa}B and activator protein-1 pathways in the interleukin-1{beta}-mediated decrease of deiodinase type 1 and thyroid hormone receptor {beta}1 mRNA.
Euthyroid Sick Syndromes
Early changes in thyroid hormone metabolism in the heart, liver, and brown adipose tissue during the induction of low T3 syndrome in streptozotocin-diabetic rats.
Euthyroid Sick Syndromes
Inflammatory cytokines and type I 5'-deiodinase expression in phi1 rat liver cells.
Euthyroid Sick Syndromes
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome.
Euthyroid Sick Syndromes
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.
Euthyroid Sick Syndromes
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Fatty Liver
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Fatty Liver
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Fatty Liver
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Fatty Liver
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
Fatty Liver
The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
Fetal Death
Effect of methyl iodide on deiodinase activity.
Fetal Growth Retardation
Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies.
Fetal Resorption
Effect of methyl iodide on deiodinase activity.
Fibrous Dysplasia, Polyostotic
The role of type 1 and type 2 5'-deiodinase in the pathophysiology of the 3,5,3'-triiodothyronine toxicosis of McCune-Albright syndrome.
Gastritis
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults.
Glucose Intolerance
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Goiter
Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter.
Goiter
Effects of Dietary Soy Intake on Maternal Thyroid Functions and Serum Anti-Thyroperoxidase Antibody Level During Early Pregnancy.
Goiter
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.
Goiter
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Goiter, Endemic
Comparative studies of diiodotyrosine deiodinase activities in endemic goiter and congenital goiter.
Goiter, Endemic
[Liver deiodinase activity in rats after high and low fat iodine deficient diets]
Graves Disease
Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy.
Graves Disease
Heterogenous biochemical expression of hormone activity in subclinical/overt hyperthyroidism and exogenous thyrotoxicosis.
Graves Disease
Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera.
Graves Disease
Mechanisms governing the relative proportions of thyroxine and 3,5,3'-triiodothyronine in thyroid secretion.
Graves Disease
Pax-8 expression correlates with type II 5' deiodinase expression in thyroids from patients with Graves' disease.
Graves Disease
Quantitative measurements for type 1 deiodinase messenger ribonucleic acid in human peripheral blood mononuclear cells: mechanism of the preferential increase of T3 in hyperthyroid Graves' disease.
Graves Disease
Spin echo nuclear magnetic resonance studies on intact erythrocytes: changes in cellular metabolism as a consequence of carbimazole therapy.
Graves Disease
Study of Deiodinase Type 2 Polymorphisms in Graves' Disease and Ophthalmopathy in a Swedish Population.
Graves Disease
The selenium analog of 6-propylthiouracil. Measurement of its inhibitory effect on type I iodothyronine deiodinase and of its antithyroid activity.
Graves Disease
Thr92Ala polymorphism of human type 2 deiodinase gene (hD2) affects the development of Graves' disease, treatment efficiency, and rate of remission.
Graves Disease
Thyroid over-expression of type 1 and type 2 deiodinase may account for the syndrome of low thyroxine and increasing triiodothyronine during propylthiouracil treatment.
Graves Disease
Type 2 deiodinase Thr92Ala polymorphism impact on clinical course and myocardial remodeling in patients with Graves' disease.
Graves Ophthalmopathy
Immunohistochemical studies using immunized Guinea pig sera with features of anti-human thyroid, eye and skeletal antibody and Graves' sera.
Hashimoto Disease
The Thr92Ala polymorphism in the type 2 deiodinase is not associated with thyroxine dose in athyroid patients or patients with Hashimoto thyroiditis.
Hearing Loss
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase.
Heart Diseases
Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction.
Heart Failure
Long-term L-Triiodothyronine (T3) treatment in stable systolic heart failure patients: a randomised, double-blind, cross-over, placebo-controlled intervention study.
Heart Failure
Tissue thyroid hormones and thyronamines.
Hemangioendothelioma
Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation.
Hemangioma
Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy.
Hemangioma
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Hemangioma
Multiple infantile hepatic hemangiomas leading to consumptive hypothyroidism successfully treated with propranolol: A case report.
Hemangioma
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study.
Hypercholesterolemia
Hypercholesterolemia and tissue-specific differential mRNA expression of type-1 5'-iodothyronine deiodinase under different selenium status in rats.
Hyperglycemia
Peripheral deiodinase activity: A potential explanation for the association between maternal weight and gestational hyperglycemia.
Hypertension
Ala92 type 2 deiodinase allele increases risk for the development of hypertension.
Hypertension
Impact of thyroid function and polymorphisms in the type 2 deiodinase on blood pressure: the Rotterdam Study and the Rotterdam Scan Study.
Hypertension
Response to Type 2 Deiodinase Thr92Ala Polymorphism Is Not Associated With Arterial Hypertension in Type 2 Diabetes Mellitus Patients.
Hypertension
Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients.
Hyperthyroidism
3,5-Diiodothyronine in vivo maintains euthyroidal expression of type 2 iodothyronine deiodinase, growth hormone, and thyroid hormone receptor beta1 in the killifish.
Hyperthyroidism
Activities of UDP-glucuronyltransferase, beta-glucuronidase and deiodinase types I and II in hyper- and hypothyroid rats.
Hyperthyroidism
Adrenergic activation of triiodothyronine production in brown adipose tissue.
Hyperthyroidism
Adult Mice Lacking Mct8 and Dio2 Proteins Present Alterations in Peripheral Thyroid Hormone Levels and Severe Brain and Motor Skill Impairments.
Hyperthyroidism
Beneficial role of ascorbic and folic acids antioxidants against thyroxin-induced testicular dysfunction in hyperthyroid rats.
Hyperthyroidism
Cecal microbial transplantation attenuates hyperthyroid-induced thermogenesis in Mongolian gerbils.
Hyperthyroidism
Consequences of monocarboxylate transporter 8 deficiency for renal transport and metabolism of thyroid hormones in mice.
Hyperthyroidism
Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T?in the mouse cerebral cortex.
Hyperthyroidism
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Hyperthyroidism
Dual mechanisms of regulation of type I iodothyronine 5'-deiodinase in the rat kidney, liver, and thyroid gland. Implications for the treatment of hyperthyroidism with radiographic contrast agents.
Hyperthyroidism
Effect of antithyroid drugs on the occurrence of antibodies against type 2 deiodinase (DIO2), which are involved in hyperthyroid Graves' disease influencing the therapeutic efficacy.
Hyperthyroidism
Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus.
Hyperthyroidism
Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene.
Hyperthyroidism
Hyperthyroidism in Patients with Graves' Ophthalmopathy, and Thyroidal, Skeletal and Eye Muscle Specific Type 2 Deiodinase Enzyme Activities.
Hyperthyroidism
Iodothyronine deiodination in rats with severe non-thyroidal illness.
Hyperthyroidism
Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus.
Hyperthyroidism
Pituitary-thyroid interaction: effects of thyroid hormone, non thyroidal illness and various agents on TSH secretion.
Hyperthyroidism
Quantitative measurements for type 1 deiodinase messenger ribonucleic acid in human peripheral blood mononuclear cells: mechanism of the preferential increase of T3 in hyperthyroid Graves' disease.
Hyperthyroidism
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone.
Hyperthyroidism
Relative developmental toxicities of pentachloroanisole and pentachlorophenol in a zebrafish model (Danio rerio).
Hyperthyroidism
Sources of circulating 3,5,3'-triiodothyronine in hyperthyroidism estimated after blocking of type 1 and type 2 iodothyronine deiodinases.
Hyperthyroidism
Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: cloning and use of iodothyronine deiodinases as molecular biomarkers.
Hyperthyroidism
Thyroid function and body weight programming by neonatal hyperthyroidism in rats - the role of leptin and deiodinase activities.
Hyperthyroidism
Thyroid over-expression of type 1 and type 2 deiodinase may account for the syndrome of low thyroxine and increasing triiodothyronine during propylthiouracil treatment.
Hyperthyroidism
Type 1 iodothyronine deiodinase is the major source of circulating T3 in hyperthyroidism: implications for therapy.
Hyperthyroidism
Volume 250, Number 3 (1998), in Article No. RC989358, "Quantitative Measurements for Type 1 Deiodinase Messenger Ribonucleic Acid in Human Peripheral Blood Mononuclear Cells: Mechanism of the Preferential Increase of T3 in Hyperthyroid Graves' Disease," by Mitsushige Nishikawa, Nagaoki Toyoda, Toshinaga Yonemoto, Yoshifumi Ogawa, Sakuyoshi Tabata, Noriko Sakaguchi, Toshiko Tokoro, Atsushi Gondou, Masayoshi Yoshimura, Norio Yoshikawa, and Mitsuo Inada, pages 642-646.
Hypertriglyceridemia
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Hypertrophy, Right Ventricular
MYOCARDIAL INACTIVATION OF THYROID HORMONES IN PATIENTS WITH AORTIC STENOSIS.
Hypothyroidism
5' Deiodinase activity in brain regions of adult rats: modifications in different situations of experimental hypothyroidism.
Hypothyroidism
Adrenergic activation of triiodothyronine production in brown adipose tissue.
Hypothyroidism
Brain gene expression in systemic hypothyroidism and mouse models of MCT8 deficiency: The Mct8-Oatp1c1-Dio2 triad.
Hypothyroidism
Cognitive function in hypothyroidism: what is that deiodinase again?
Hypothyroidism
Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism.
Hypothyroidism
Consumptive Hypothyroidism Due to Diffuse Hepatic Hemangiomas Treated With Propranolol Therapy.
Hypothyroidism
Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.
Hypothyroidism
Critical role of types 2 and 3 deiodinases in the negative regulation of gene expression by T?in the mouse cerebral cortex.
Hypothyroidism
D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.
Hypothyroidism
Disruption of the pituitary circadian clock induced by hypothyroidism and hyperthyroidism: consequences on daily pituitary hormone expression profiles.
Hypothyroidism
Effects of hyper- and hypothyroidism on thyroid hormone concentrations in regions of the rat brain.
Hypothyroidism
Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish.
Hypothyroidism
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Hypothyroidism
Establishment of an Effective Radioiodide Thyroid Ablation Protocol in Mice.
Hypothyroidism
Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature.
Hypothyroidism
Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome.
Hypothyroidism
Feedback regulation of thyrotropin-releasing hormone gene expression by thyroid hormone in the hypothalamic paraventricular nucleus.
Hypothyroidism
Hypothyroidism induces type 2 iodothyronine deiodinase expression in mouse heart and testis.
Hypothyroidism
Hypothyroidism induces type I iodothyronine deiodinase expression in tilapia liver.
Hypothyroidism
Inhibition of pituitary type 2 deiodinase by reverse triiodothyronine does not alter thyroxine-induced inhibition of thyrotropin secretion in hypothyroid rats.
Hypothyroidism
Low-dose t3 replacement restores depressed cardiac t3 levels, preserves coronary microvasculature and attenuates cardiac dysfunction in experimental diabetes mellitus.
Hypothyroidism
Managing symptoms in hypothyroid patients on adequate levothyroxine: a narrative review.
Hypothyroidism
Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
Hypothyroidism
Minireview: the neural regulation of the hypothalamic-pituitary-thyroid axis.
Hypothyroidism
MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.
Hypothyroidism
Myocardial Induction of Type 3 Deiodinase in Dilated Cardiomyopathy.
Hypothyroidism
Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
Hypothyroidism
Pathophysiological relevance of deiodinase polymorphism.
Hypothyroidism
Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.
Hypothyroidism
Perchlorate Exposure Induces Hypothyroidism and Affects Thyroid-Responsive Genes in Liver But Not Brain of Quail Chicks.
Hypothyroidism
Pituitary-thyroid interaction: effects of thyroid hormone, non thyroidal illness and various agents on TSH secretion.
Hypothyroidism
Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
Hypothyroidism
Reduction in NPY-positive neurons and dysregulation of excitability in young senescence-accelerated mouse prone 8 (SAMP8) hippocampus precede the onset of cognitive impairment.
Hypothyroidism
Regulation of thyroxine 5'-deiodinase activity by 3,5,3'-triiodothyronine in cultured rat anterior pituitary cells.
Hypothyroidism
Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.
Hypothyroidism
Selenium deficiency mitigates hypothyroxinemia in iodine-deficient subjects.
Hypothyroidism
Severe consumptive hypothyroidism caused by multiple infantile hepatic haemangiomas.
Hypothyroidism
Sunitinib-Induced Hypothyroidism Is due to Induction of Type 3 Deiodinase Activity and Thyroidal Capillary Regression.
Hypothyroidism
The impact of thyroid hormone dysfunction on ischemic heart disease.
Hypothyroidism
The roles of the iodothyronine deiodinases in mammalian development.
Hypothyroidism
The selective loss of the type 2 iodothyronine deiodinase in mouse thyrotrophs increases basal TSH but blunts the thyrotropin response to hypothyroidism.
Hypothyroidism
Thyroid disease and mental disorders: cause and effect or only comorbidity?
Hypothyroidism
Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
Hypothyroidism
Thyroid hormone deiodination in the brain of young chickens acutely adapts to changes in thyroid status.
Hypothyroidism
Thyroid hormones and modulation of diastolic function: a promising target for heart failure with preserved ejection fraction.
Hypothyroidism
Thyroxine replacement modifies changes in deiodinase and thyroid hormone transporter expression induced by subclinical hypothyroidism in rats.
Hypothyroidism
Tissue thyroid hormones and thyronamines.
Hypothyroidism
Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice.
Hypothyroidism
Triiodothyronine administration ameliorates the demyelination/remyelination ratio in a non-human primate model of multiple sclerosis by correcting tissue hypothyroidism.
Hypothyroidism
Triiodothyronine causes rapid reversal of alpha 1/cyclic adenosine monophosphate synergism on brown adipocyte respiration and type II deiodinase activity.
Hypothyroidism
Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
Hypothyroidism
Type 2 Iodothyronine Deiodinase in Skeletal Muscle: Effects of Hypothyroidism and Fasting.
Hypothyroidism
Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
Hypothyroidism
Type 2 Iodothyronine Deiodinase Levels Are Higher in Slow-Twitch than Fast-Twitch Mouse Skeletal Muscle and Are Increased in Hypothyroidism.
Hypothyroidism
Type 3 Deiodinase and Consumptive Hypothyroidism: A Common Mechanism for a Rare Disease.
Hypothyroidism
[Hormonal and metabolic studies in a case of athyreotic hypothyroidism with secondary hypoactivity of deiodinase]
Hypothyroidism
[Hypothalamic-pituitary-thyroid axis in depression]
Idiopathic Pulmonary Fibrosis
Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
Infections
Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS.
Infections
Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome.
Infections
Hepatitis C Virus Infection of Human Thyrocytes: Metabolic, Hormonal, and Immunological Implications.
Infections
The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils.
Insulin Resistance
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.
Insulin Resistance
Diet-induced insulin resistance is associated with decreased activity of type I iodothyronine 5'-deiodinase in rat liver.
Insulin Resistance
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Insulin Resistance
Interaction of DIO2 T92A and PPARgamma2 P12A polymorphisms in the modulation of metabolic syndrome.
Insulin Resistance
The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.
Insulin Resistance
The Asp727Glu polymorphism in the TSH receptor is associated with insulin resistance in healthy elderly men.
Insulin Resistance
The rs225017 polymorphism in the 3'UTR of the human DIO2 gene is associated with increased insulin resistance.
Insulin Resistance
The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish.
Insulin Resistance
The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
Insulin Resistance
Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study.
Insulin Resistance
Weight Loss Through Gastric Banding: Effects on TSH and Thyroid Hormones in Obese Subjects With Normal Thyroid Function.
Intellectual Disability
A family-based association study of DIO2 and children mental retardation in the Qinba region of China.
Iron Deficiencies
Plasma thyroid hormone kinetics are altered in iron-deficient rats.
Ischemic Stroke
Deiodinases, organic anion transporter polypeptide polymorphisms and ischemic stroke outcomes.
Kidney Failure, Chronic
The relationship between inflammatory factors, oxidative stress and DIO-1 concentration in patients with chronic renal failure accompanied with or without euthyroid sick syndrome.
Kidney Neoplasms
Determining the enzymatic activities of iodothyronine 5'-deiodinases in renal medulla and cortex.
Kidney Neoplasms
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer.
Kidney Neoplasms
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells.
Kidney Neoplasms
MiR-224 targets the 3'UTR of type 1 5'-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer.
Kidney Neoplasms
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.
Leber Congenital Amaurosis
Deficiency of type 2 iodothyronine deiodinase reduces necroptosis activity and oxidative stress responses in retinas of Leber congenital amaurosis model mice.
Liver Diseases
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
Lung Diseases
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Lung Diseases, Obstructive
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Lung Neoplasms
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
Lung Neoplasms
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Lung Neoplasms
[Examination of thyroxine conversion to triiodothyronine in the lungs (preliminary report)]
Malabsorption Syndromes
MANAGEMENT OF ENDOCRINE DISEASE: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults.
Malnutrition
Liver deiodinase activity is increased in adult rats whose mothers were submitted to malnutrition during lactation.
Malnutrition
Neonatal low-protein diet changes deiodinase activities and pituitary TSH response to TRH in adult rats.
Mesothelioma
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
Metabolic Syndrome
Subcutaneous Adipose Tissue Type II Deiodinase Gene Expression Reduced in Obese Individuals with Metabolic Syndrome.
Muscular Atrophy
Thyroid hormones and skeletal muscle-new insights and potential implications.
Muscular Diseases
Thyroid hormones and skeletal muscle-new insights and potential implications.
Muscular Diseases
[Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System].
Myocardial Infarction
Cardiac expression of deiodinase type 3 (Dio3) following myocardial infarction is associated with the induction of a pluripotency microRNA signature from the Dlk1-Dio3 genomic region.
Myocardial Infarction
MicroRNA 214 Is a Potential Regulator of Thyroid Hormone Levels in the Mouse Heart Following Myocardial Infarction, by Targeting the Thyroid-Hormone-Inactivating Enzyme Deiodinase Type III.
Myocardial Infarction
Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Myocardial Infarction
Remarkable effect of chalcogen substitution on an enzyme mimetic for deiodination of thyroid hormones.
Neoplasm Metastasis
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Neoplasm Metastasis
Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma.
Neoplasms
3,5,3'-Triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) synthesis in rats hosting the R3230AC mammary tumour.
Neoplasms
3,5,3'-Triiodothyronine thyrotoxicosis due to increased conversion of administered levothyroxine in patients with massive metastatic follicular thyroid carcinoma.
Neoplasms
?-Catenin Regulates Deiodinase Levels and Thyroid Hormone Signaling in Colon Cancer Cells.
Neoplasms
A novel mechanism for the inhibition of type 2 iodothyronine deiodinase by tumor necrosis factor ?: involvement of proteasomal degradation.
Neoplasms
Colorectal cancer causes alteration of thyroid hormone profile in newly diagnosed patients.
Neoplasms
Consumptive Hypothyroidism: Case Report of Hepatic Hemangioendotheliomas Successfully Treated with Vincristine and Systematic Review of the Syndrome.
Neoplasms
Decreased expression of the thyroid hormone-inactivating enzyme type 3 deiodinase is associated with lower survival rates in breast cancer.
Neoplasms
Deiodinases and Cancer.
Neoplasms
Deiodination in cancer growth: the role of type III deiodinase.
Neoplasms
DIO3, the thyroid hormone inactivating enzyme, promotes tumorigenesis and metabolic reprogramming in high grade serous ovarian cancer.
Neoplasms
Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours.
Neoplasms
Effect of somatotropin on thyroid hormones and cytokines in lactating dairy cows during ad libitum and restricted feed intake.
Neoplasms
Efficacy of Propranolol Treatment in Thyroid Dysfunction Associated with Severe Infantile Hepatic Hemangioma.
Neoplasms
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors.
Neoplasms
Expression and regulation of type II iodothyronine deiodinase in human thyroid gland.
Neoplasms
INCREASED TYPE 3 DEIODINASE EXPRESSION IN PAPILLARY THYROID CARCINOMA.
Neoplasms
Increased type 3 deiodinase expression in papillary thyroid carcinoma.
Neoplasms
LRRC19-A Bridge between Selenium Adjuvant Therapy and Renal Clear Cell Carcinoma: A Study Based on Datamining.
Neoplasms
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.
Neoplasms
Metastatic Follicular Thyroid Carcinoma as a Cause of Low Serum Thyroxine with a Normal Thyroid Stimulating Hormone Level.
Neoplasms
mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary carcinoma.
Neoplasms
Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells.
Neoplasms
Remarkable effect of chalcogen substitution on an enzyme mimetic for deiodination of thyroid hormones.
Neoplasms
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system.
Neoplasms
Role of type 3 deiodinase in cancer.
Neoplasms
Selenium and the control of thyroid hormone metabolism.
Neoplasms
Sphingomyelinase and phospholipase A2 regulate type I deiodinase expression in FRTL-5 cells.
Neoplasms
Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in Apc?716 mutant mice.
Neoplasms
The conversion of thyroxine to triiodothyronine in the lung: comparison of activity of type I iodothyronine 5' deiodinase in lung cancer with peripheral lung tissues.
Neoplasms
Thyroid hormone deiodinases and cancer.
Neoplasms
Thyroid hormone receptors and type I iodothyronine 5'-deiodinase activity of human thyroid toxic adenomas and benign cold nodules.
Neoplasms
Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma.
Neoplasms
Type 3 deiodinase and solid tumors: an intriguing pair.
Neoplasms
Type 3 deiodinase: role in cancer growth, stemness, and metabolism.
Neoplasms
[Iodothyronine deiodinases expression in thyroid neoplasias]
Neuroblastoma
Carbohydrate reactivation of thyroxine 5'-deiodinase (type II) in cultured mouse neuroblastoma cells is dependent upon new protein synthesis.
Neuroblastoma
Cyclic adenosine 3',5'-monophosphate and glucose stimulate thyroxine 5'-deiodinase type II in cultured mouse neuroblastoma cells.
Neuroblastoma
Hormonal control of a low Km (type II) iodothyronine 5'-deiodinase in cultured NB41A3 mouse neuroblastoma cells.
Neuroblastoma
Methylmercury inhibition of type II 5'-deiodinase activity resulting in a decrease in growth hormone production in GH3 cells.
Neuroblastoma
Methylmercury inhibits type II 5'-deiodinase activity in NB41A3 neuroblastoma cells.
Neurologic Manifestations
A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.
Nevus, Pigmented
Germ Line Mutations in the Thyroid Hormone Receptor Alpha Gene Predispose to Cutaneous Tags and Melanocytic Nevi.
Non-alcoholic Fatty Liver Disease
Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression.
Obesity
Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor.
Obesity
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice.
Obesity
Dietary soy protein induces hepatic lipogenic enzyme gene expression while suppressing hepatosteatosis in obese female Zucker rats bearing DMBA-initiated mammary tumors.
Obesity
Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
Obesity
Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
Obesity
Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.
Obesity
Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
Obesity
Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
Obesity
Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.
Obesity
The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.
Osteoarthritis
Deiodinase 2 upregulation demonstrated in osteoarthritis patients cartilage causes cartilage destruction in tissue-specific transgenic rats.
Osteoarthritis
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
Osteoarthritis
Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility.
Osteoarthritis
Novel insights into thyroid hormones from the study of common genetic variation.
Osteoarthritis
Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis.
Osteoarthritis
The effect of forced exercise on knee joints in Dio2-/- mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.
Osteoarthritis
[Osteoarthropathies and Myopathies associated with Disorders of the Thyroid Endocrine System].
Osteochondrodysplasias
Differential expression of iodothyronine deiodinase type 2 in growth plates of chickens divergently selected for incidence of tibial dyschondroplasia.
Osteosarcoma
Expression of type 2 iodothyronine deiodinase in human osteoblast is stimulated by thyrotropin.
Overweight
Maternal adiposity, smoking, and thyroid function in early pregnancy.
Pituitary Neoplasms
Dysregulation of iodothyronine deiodinase enzyme expression and function in human pituitary tumours.
Pituitary Neoplasms
Expression of type 2 iodothyronine deiodinase in corticotropin-secreting mouse pituitary tumor cells is stimulated by glucocorticoid and corticotropin-releasing hormone.
Pituitary Neoplasms
Metabolic effect of 3,3',5'-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. Evidence for a unique mechanism of thyroid hormone action.
Pituitary Neoplasms
Nuclear all-trans retinoic acid receptors: in vitro effects of selenium.
Pituitary Neoplasms
Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction.
Pituitary Neoplasms
The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5'-deiodinase.
Pituitary Neoplasms
Thyroxine 5'-deiodinase in human anterior pituitary tumors.
Pituitary Neoplasms
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes.
Polycystic Ovary Syndrome
Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Free triiodothyronine /free thyroxine ratio as an index of deiodinase type 1 and 2 activities negatively correlates with casual serum insulin levels in patients with type 2 diabetes mellitus.
Pre-Eclampsia
D2-Thr92Ala, thyroid hormone levels and biochemical hypothyroidism in preeclampsia.
Pre-Eclampsia
Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats.
Pre-Eclampsia
The effect of the D1-C785T polymorphism in the type 1 iodothyronine deiodinase gene on the circulating thyroid hormone levels in Romanian women with preeclampsia. Association with the degree of severity and pregnancy outcome of preeclampsia.
Pre-Eclampsia
Thyroid hormones and their placental deiodination in normal and pre-eclamptic pregnancy.
Pulmonary Disease, Chronic Obstructive
Assessment of serum levels of DIO1 and DIO3 in patients diagnosed with COPD.
Pulmonary Disease, Chronic Obstructive
Association of serum deiodinase type 2 level with chronic obstructive pulmonary disease in the Polish population.
Retinopathy of Prematurity
Thyroid Activating Enzyme, Deiodinase II Is Required for Photoreceptor Function in the Mouse Model of Retinopathy of Prematurity.
Sepsis
Erratum: Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Sepsis
Type 2 Deiodinase and Host Responses of Sepsis and Acute Lung Injury.
Shock, Septic
Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock.
Starvation
Exercise in a pill: feasibility of energy expenditure targets.
Status Epilepticus
Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
Stomach Neoplasms
Prognostic Significance of Sodium Iodide Symporter and Deiodinase Enzymes mRNA Expression in Gastric Cancer.
Thyroid Cancer, Papillary
Disturbed expression of type 1 and type 2 iodothyronine deiodinase as well as titf1/nkx2-1 and pax-8 transcription factor genes in papillary thyroid cancer.
Thyroid Cancer, Papillary
INCREASED TYPE 3 DEIODINASE EXPRESSION IN PAPILLARY THYROID CARCINOMA.
Thyroid Cancer, Papillary
Increased type 3 deiodinase expression in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma.
Thyroid Cancer, Papillary
Positive correlation between type 1 and 2 iodothyronine deiodinases activities in human goiters.
Thyroid Diseases
Association of antipituitary antibody and type 2 iodothyronine deiodinase antibody in patients with autoimmune thyroid disease.
Thyroid Diseases
Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases.
Thyroid Dysgenesis
The role of serum thyroglobulin concentration and thyroid ultrasound imaging in the detection of iodide transport defects in infants.
Thyroid Neoplasms
A study of the role of DIO1 and DIO2 polymorphism in thyroid cancer and drug response to therapy in the Saudi population.
Thyroid Neoplasms
Human breast cancer tissue expresses high level of type 1 5'-deiodinase.
Thyroid Neoplasms
The Type 2 Deiodinase ORFa-Gly3Asp Polymorphism (rs12885300) Influences the Set Point of the Hypothalamus-Pituitary-Thyroid Axis in Patients Treated for Differentiated Thyroid Carcinoma.
Thyroid Neoplasms
Tumour re-differentiation effect of retinoic acid: a novel therapeutic approach for advanced thyroid cancer.
Thyroid Neoplasms
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma.
Thyroiditis
The spectrum of thyroid function tests during hospitalization for SARS COV-2 infection.
Thyroiditis
[Endocrine complications of modern cancer therapy].
Thyrotoxicosis
Thyrotropin (TSH) action on thyroid hormone deiodination and secretion: one aspect of thyrotropin regulation of thyroid cell biology.
Thyrotoxicosis
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis.
thyroxine 5'-deiodinase deficiency
Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency.
thyroxine 5'-deiodinase deficiency
Adult onset of type 3 deiodinase deficiency in mice alters brain gene expression and increases locomotor activity.
thyroxine 5'-deiodinase deficiency
Diagnostic confusion attributable to spurious elevation of both total thyroid hormone and thyroid hormone uptake measurements in the setting of autoantibodies: case report and review of related literature.
thyroxine 5'-deiodinase deficiency
Evolution of hypothyroidism in familial goitre due to deiodinase deficiency: report of a family and review of the literature.
thyroxine 5'-deiodinase deficiency
Insights into the role of deiodinases from studies of genetically modified animals.
thyroxine 5'-deiodinase deficiency
Iodothyronine-5'-deiodinase activity in progenies of hypothyroid rats.
thyroxine 5'-deiodinase deficiency
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells.
thyroxine 5'-deiodinase deficiency
Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency.
thyroxine 5'-deiodinase deficiency
Physiological role and regulation of iodothyronine deiodinases: a 2011 update.
thyroxine 5'-deiodinase deficiency
Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency.
thyroxine 5'-deiodinase deficiency
Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels.
thyroxine 5'-deiodinase deficiency
Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Yu, J.; Koenig, R.J.
Regulation of hepatocyte thyroxine 5'-deiodinase by T3 and nuclear receptor coactivators as a model of the sick euthyroid syndrome
J. Biol. Chem.
275
38296-38301
2000
Homo sapiens, Mus musculus, Rattus sp.
brenda
Garcia-Macias, J.F.; Molinero, P.; Guerrero, J.M.; Osuna, C.
Expression of type II thyroxine 5'-deiodinase from rat harderian gland in Xenopus laevis oocytes
FEBS Lett.
354
110-112
1994
Homo sapiens, Rattus sp.
brenda
Santini, F.; Chopra, I.J.; Hurd, R.E.; Chua Teco, G.N.
A study of the characteristics of hepatic iodothyronine 5'-monodeiodinase in various vertebrate species
Endocrinology
131
830-834
1992
Bos taurus, Cavia porcellus, Gallus gallus, Ovis aries, Homo sapiens, Mus musculus, Rattus sp., Sus scrofa
brenda
Koehrle, J.
Iodothyronine deiodinases
Methods Enzymol.
347
125-167
2002
Bos taurus, Homo sapiens, Mus musculus, Rattus norvegicus, vertebrata
brenda
Steinsapir, J.; Bianco, A.C.; Buettner, C.; Harney, J.; Larsen, P.R.
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center
Endocrinology
141
1127-1135
2000
Homo sapiens (Q92813), Homo sapiens
brenda
Buettner, C.; Harney, J.W.; Larsen, P.R.
The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase
Endocrinology
141
4606-4612
2000
Homo sapiens (Q92813), Homo sapiens
brenda
Kuiper, G.G.; Klootwijk, W.; Visser, T.J.
Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
Endocrinology
143
1190-1198
2002
Homo sapiens (Q92813), Homo sapiens
brenda
Curcio-Morelli, C.; Gereben, B.; Zavacki, A.M.; Kim, B.W.; Huang, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases
Endocrinology
144
937-946
2003
Homo sapiens (P49895), Homo sapiens (Q92813), Homo sapiens
brenda
Curcio, C.; Baqui, M.M.; Salvatore, D.; Rihn, B.H.; Mohr, S.; Harney, J.W.; Larsen, P.R.; Bianco, A.C.
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line
J. Biol. Chem.
276
30183-30187
2001
Homo sapiens (Q92813), Homo sapiens
brenda
Kanou, Y.; Hishinuma, A.; Tsunekawa, K.; Seki, K.; Mizuno, Y.; Fujisawa, H.; Imai, T.; Miura, Y.; Nagasaka, T.; Yamada, C.; Ieiri, T.; Murakami, M.; Murata, Y.
Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity
J. Clin. Endocrinol. Metab.
92
1451-1457
2007
Homo sapiens
brenda
Aerts, G.; Arrojo E Drigo, R.; Van Herck, S.L.; Sammels, E.; Mirebeau-Prunier, D.; Gereben, B.; Zeoeld, A.; Harney, J.W.; Huang, S.A.; Mulcahey, M.A.; Van der Geyten, S.; Van den Bergh, G.; Arckens, L.; Darras, V.M.; Zavacki, A.M.
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells
Endocrinology
150
5171-5180
2009
Homo sapiens (P49895), Homo sapiens (Q92813)
brenda
Celi, F.S.; Coppotelli, G.; Chidakel, A.; Kelly, M.; Brillante, B.A.; Shawker, T.; Cherman, N.; Feuillan, P.P.; Collins, M.T.
The role of type 1 and type 2 5-deiodinase in the pathophysiology of the 3,5,3-triiodothyronine toxicosis of McCune-Albright syndrome
J. Clin. Endocrinol. Metab.
93
2383-2389
2008
Homo sapiens
brenda
Zavacki, A.M.; Arrojo E Drigo, R.; Freitas, B.C.; Chung, M.; Harney, J.W.; Egri, P.; Wittmann, G.; Fekete, C.; Gereben, B.; Bianco, A.C.
The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase
Mol. Cell. Biol.
29
5339-5347
2009
Homo sapiens
brenda
Meyer, E.L.; Goemann, I.M.; Dora, J.M.; Wagner, M.S.; Maia, A.L.
Type 2 iodothyronine deiodinase is highly expressed in medullary thyroid carcinoma
Mol. Cell. Endocrinol.
289
16-22
2008
Homo sapiens
brenda
Piekielko-Witkowska, A.; Master, A.; Wojcicka, A.; Boguslawska, J.; Brozda, I.; Tanski, Z.; Nauman, A.
Disturbed expression of type 1 iodothyronine deiodinase splice variants in human renal cancer
Thyroid
19
1105-1113
2009
Homo sapiens (P49895), Homo sapiens
brenda
Goto, K.; Sonoda, D.; Shimada, K.; Sase, S.; Kawashima, T.
Modeling of the 5'-deiodination of thyroxine by iodothyronine deiodinase: Chemical corroboration of a selenenyl iodide intermediate
Angew. Chem.
49
545-547
2010
Homo sapiens
brenda
Manna, D.; Mugesh, G.
A chemical model for the inner-ring deiodination of thyroxine by iodothyronine deiodinase
Angew. Chem.
49
9246-9249
2010
Homo sapiens
-
brenda
Kornasiewicz, O.; Debski, M.; Stepnowska, M.; Sza?as, A.; Bar-Andziak, E.; Krawczyk, M.
The enzymatic activity of type 1 iodothyronine deiodinase (D1) is low in liver hemangioma: a preliminary study
Arch. Immunol. Ther. Exp.
58
77-80
2010
Homo sapiens
brenda
Goemann, I.; Gereben, B.; Harney, J.; Zhu, B.; Maia, A.; Larsen, P.
Substitution of serine for proline in the active center of type 2 iodothyronine deiodinase substantially alters its in vitro biochemical properties with dithiothreitol but not its function in intact cells
Endocrinology
151
821-829
2010
Homo sapiens
brenda
Ito, M.; Toyoda, N.; Nomura, E.; Takamura, Y.; Amino, N.; Iwasaka, T.; Takamatsu, J.; Miyauchi, A.; Nishikawa, M.
Type 1 and type 2 iodothyronine deiodinases in the thyroid gland of patients with 3,5,3'-triiodothyronine-predominant Graves' disease
Eur. J. Endocrinol.
164
95-100
2011
Homo sapiens
brenda
Piehl, S.; Heberer, T.; Balizs, G.; Scanlan, T.S.; Kohrle, J.
Development of a validated liquid chromatography/tandem mass spectrometry method for the distinction of thyronine and thyronamine constitutional isomers and for the identification of new deiodinase substrates
Rapid Commun. Mass Spectrom.
22
3286-3296
2008
Homo sapiens, Mus musculus
brenda
Kornasiewicz, O.; Debski, M.; Grat, M.; Lenartowicz, B.; Stepnowska, M.; Szalas, A.; Bar-Andziak, E.; Krawczyk, M.
Enzymatic activity of type 1 iodothyronine deiodinase in selected liver tumors
Arch. Med. Sci.
10
801-805
2014
Homo sapiens (P49895), Homo sapiens
brenda
Aoki, T.; Tsunekawa, K.; Araki, O.; Ogiwara, T.; Nara, M.; Sumino, H.; Kimura, T.; Murakami, M.
Type 2 iodothyronine deiodinase activity is required for rapid stimulation of PI3K by thyroxine in human umbilical vein endothelial cells
Endocrinology
156
4312-4324
2015
Homo sapiens (Q9C0K2), Homo sapiens
brenda
Yamauchi, I.; Sakane, Y.; Yamashita, T.; Hirota, K.; Ueda, Y.; Kanai, Y.; Yamashita, Y.; Kondo, E.; Fujii, T.; Taura, D.; Sone, M.; Yasoda, A.; Inagaki, N.
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans
Endocrine
59
353-363
2018
Homo sapiens
brenda
Poplawski, P.; Rybicka, B.; Boguslawska, J.; Rodzik, K.; Visser, T.J.; Nauman, A.; Piekielko-Witkowska, A.
Induction of type 1 iodothyronine deiodinase expression inhibits proliferation and migration of renal cancer cells
Mol. Cell. Endocrinol.
442
58-67
2017
Homo sapiens
brenda
Sakane, Y.; Kanamoto, N.; Yamauchi, I.; Tagami, T.; Morita, Y.; Miura, M.; Sone, M.; Yasoda, A.; Kimura, T.; Nakao, K.; Inagaki, N.
Regulation of type 1 iodothyronine deiodinase by LXRalpha
PLoS ONE
12
e0179213
2017
Homo sapiens
brenda
Poplawski, P.; Wisniewski, J.; Rijntjes, E.; Richards, K.; Rybicka, B.; Kohrle, J.; Piekielko-Witkowska, A.
Restoration of type 1 iodothyronine deiodinase expression in renal cancer cells downregulates oncoproteins and affects key metabolic pathways as well as anti-oxidative system
PLoS ONE
12
e0190179
2017
Homo sapiens
brenda
1.21.99.4 thyroxine 5'-deiodinase
more
top
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
