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EC Tree
IUBMB Comments This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
cyclic dehypoxanthine futalosine synthetase, cyclic DHFL synthetase, dehypoxanthinyl futalosine cyclase, DHFL cyclase, MqnC,
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cyclic dehypoxanthine futalosine synthetase
dehypoxanthinyl futalosine cyclase
cyclic dehypoxanthine futalosine synthetase
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cyclic dehypoxanthine futalosine synthetase
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cyclic DHFL synthetase
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cyclic DHFL synthetase
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dehypoxanthinyl futalosine cyclase
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dehypoxanthinyl futalosine cyclase
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DHFL cyclase
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MqnC
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dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinyl futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine:S-adenosyl-L-methionine oxidoreductase (cyclizing)
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
dehypoxanthine futalosine i.e. 3-[3-[(2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl]benzoate
cyclic dehypoxanthinyl futalosine i.e. (2R,3S,4R)-3,4,5-trihydroxy-4'-oxo-3',4,4',5-tetrahydro-2'H,3H-spiro[furan-2,1'-naphthalene]-6'-carboxylate
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
dehypoxanthine futalosine i.e. 3-[3-[(2R,3S,4R)-3,4,5-trihydroxytetrahydrofuran-2-yl]propanoyl]benzoate
cyclic dehypoxanthinyl futalosine i.e. (2R,3S,4R)-3,4,5-trihydroxy-4'-oxo-3',4,4',5-tetrahydro-2'H,3H-spiro[furan-2,1'-naphthalene]-6'-carboxylate
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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dehypoxanthine futalosine + S-adenosyl-L-methionine
cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
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[4Fe-4S] cluster
4Fe-4S cluster-dependent enzyme
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SwissProt
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SwissProt
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UniProt
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UniProt
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physiological function
the enzyme is part of the futalosine pathway for menaquinone biosynthesis
physiological function
a gene disruption mutant grows efficiently in presence of synthetic cyclic dehypoxanthine futalosine
physiological function
a gene disruption mutant requires menaquinone for growth
physiological function
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a gene disruption mutant requires menaquinone for growth
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physiological function
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a gene disruption mutant grows efficiently in presence of synthetic cyclic dehypoxanthine futalosine
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physiological function
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the enzyme is part of the futalosine pathway for menaquinone biosynthesis
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anaerobic purification by nickel affinity chromatography
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recombinant plasmid encoding mqnC from Bacillus halodurans C-125 is introduced into Escherichia coli BL21(DE3)-T1R containing the Escherichia coli suf operon for coexpression of His6-MqnC with iron-sulfur cluster biogenesis proteins
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Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.
An alternative menaquinone biosynthetic pathway operating in microorganisms
Science
321
1670-1673
2008
Streptomyces coelicolor (Q9XAP2), Streptomyces coelicolor ATCC BAA-471 (Q9XAP2)
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Cooper, L.E.; Fedoseyenko, D.; Abdelwahed, S.H.; Kim, S.H.; Dairi, T.; Begley, T.P.
In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinon
Biochemistry
52
4592-4594
2013
Alkalihalobacillus halodurans (Q9K864), Alkalihalobacillus halodurans C-125 (Q9K864)
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Yajima, A.; Kouno, S.; Dairi, T.; Mogi, M.; Katsuta, R.; Seto, H.; Nukada, T.
Synthesis of (+-)-cyclic dehypoxanthine futalosine, the biosynthetic intermediate in an alternative biosynthetic pathway for menaquinones
Tetrahedron Lett.
52
4934-4937
2011
Streptomyces coelicolor (Q9XAP2), Streptomyces coelicolor ATCC BAA-471 (Q9XAP2)
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1.21.98.1 cyclic dehypoxanthinyl futalosine synthase
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