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Information on EC 1.21.4.5 - tetrachlorohydroquinone reductive dehalogenase

for references in articles please use BRENDA:EC1.21.4.5

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IUBMB Comments

The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, converts tetrachlorohydroquinone to 2,6-dichlorohydroquinone in two steps, via 2,3,6-trichlorohydroquinone, using glutathione as the reducing agent. The enzyme is sensitive to oxidation - when an internal L-cysteine residue is oxidized, the enzyme produces 2,3,5-trichloro-6-(glutathion-S-yl)-hydroquinone and 2,6-dichloro-3-(glutathion-S-yl)-hydroquinone instead of its normal products.

The enzyme appears in viruses and cellular organisms

Synonyms
tetrachlorohydroquinone dehalogenase, tchq dehalogenase, tetrachlorohydroquinone reductive dehalogenase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide = 2,3,5,6-tetrachlorohydroquinone + 2 glutathione
show the reaction diagram
(2)
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2,6-dichlorohydroquinone + Cl- + glutathione disulfide = 2,3,6-trichlorohydroquinone + 2 glutathione
show the reaction diagram
(1)
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