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Information on EC - betaine reductase

for references in articles please use BRENDA:EC1.21.4.4
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EC Tree
     1 Oxidoreductases
         1.21 Catalysing the reaction X-H + Y-H = X-Y
             1.21.4 With a disulfide as acceptor
       betaine reductase
IUBMB Comments
The reaction is observed only in the direction of betaine reduction. The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C. Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for betaine binding and trimethylamine release. Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate. Only subunit B distinguishes this enzyme from EC (glycine reductase) and EC (sarcosine reductase).
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The expected taxonomic range for this enzyme is: Peptoclostridium acidaminophilum
reductase, betaine, more
acetyl phosphate + trimethylamine + thioredoxin disulfide + H2O = betaine + phosphate + thioredoxin
show the reaction diagram
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